ID A0A177D7V1_ALTAL Unreviewed; 1480 AA.
AC A0A177D7V1;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 24-JAN-2024, entry version 31.
DE RecName: Full=Vacuolar protein sorting/targeting protein 10 {ECO:0000256|ARBA:ARBA00015369};
DE AltName: Full=Carboxypeptidase Y receptor {ECO:0000256|ARBA:ARBA00031354};
DE AltName: Full=Sortilin VPS10 {ECO:0000256|ARBA:ARBA00031250, ECO:0000256|ARBA:ARBA00031902};
GN ORFNames=CC77DRAFT_1099524 {ECO:0000313|EMBL:OAG14999.1};
OS Alternaria alternata (Alternaria rot fungus) (Torula alternata).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Pleosporomycetidae; Pleosporales; Pleosporineae; Pleosporaceae; Alternaria;
OC Alternaria sect. Alternaria; Alternaria alternata complex.
OX NCBI_TaxID=5599 {ECO:0000313|EMBL:OAG14999.1, ECO:0000313|Proteomes:UP000077248};
RN [1] {ECO:0000313|EMBL:OAG14999.1, ECO:0000313|Proteomes:UP000077248}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SRC1lrK2f {ECO:0000313|EMBL:OAG14999.1,
RC ECO:0000313|Proteomes:UP000077248};
RG DOE Joint Genome Institute;
RA Zeiner C.A., Purvine S.O., Zink E.M., Wu S., Pasa-Tolic L., Chaput D.L.,
RA Haridas S., Grigoriev I.V., Santelli C.M., Hansel C.M.;
RT "Comparative analysis of secretome profiles of manganese(II)-oxidizing
RT ascomycete fungi.";
RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Functions as a sorting receptor in the Golgi compartment
CC required for the intracellular sorting and delivery of soluble vacuolar
CC proteins, like carboxypeptidase Y (CPY) and proteinase A. Executes
CC multiple rounds of sorting by cycling between the late Golgi and a
CC prevacuolar endosome-like compartment. {ECO:0000256|ARBA:ARBA00025569}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane
CC {ECO:0000256|ARBA:ARBA00004166}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004166}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}. Prevacuolar compartment membrane
CC {ECO:0000256|ARBA:ARBA00004488}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004488}.
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DR EMBL; KV441496; OAG14999.1; -; Genomic_DNA.
DR RefSeq; XP_018380420.1; XM_018530012.1.
DR STRING; 5599.A0A177D7V1; -.
DR GeneID; 29115606; -.
DR KEGG; aalt:CC77DRAFT_1099524; -.
DR VEuPathDB; FungiDB:CC77DRAFT_1099524; -.
DR OMA; ATMSEFI; -.
DR OrthoDB; 5840at2759; -.
DR Proteomes; UP000077248; Unassembled WGS sequence.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046907; P:intracellular transport; IEA:UniProt.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR Gene3D; 2.10.70.80; -; 2.
DR Gene3D; 3.30.60.270; -; 2.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 3.
DR InterPro; IPR031777; Sortilin_C.
DR InterPro; IPR031778; Sortilin_N.
DR InterPro; IPR006581; VPS10.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR12106; SORTILIN RELATED; 1.
DR PANTHER; PTHR12106:SF27; VPS10 HOMOLOG 1-RELATED; 1.
DR Pfam; PF15902; Sortilin-Vps10; 2.
DR Pfam; PF15901; Sortilin_C; 2.
DR SMART; SM00602; VPS10; 2.
DR SUPFAM; SSF110296; Oligoxyloglucan reducing end-specific cellobiohydrolase; 2.
PE 4: Predicted;
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000077248};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..1480
FT /note="Vacuolar protein sorting/targeting protein 10"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5008059093"
FT TRANSMEM 1354..1375
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 49..668
FT /note="VPS10"
FT /evidence="ECO:0000259|SMART:SM00602"
FT DOMAIN 706..1343
FT /note="VPS10"
FT /evidence="ECO:0000259|SMART:SM00602"
FT REGION 646..675
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1016..1043
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1459..1480
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 647..675
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1480 AA; 166707 MW; C2E74595B9FD6FC0 CRC64;
MMKYLKGLLL PALLALASTA AAKKEEPLVE TTAFKNDIVN ILYFDDSGVA LLQELETGSI
WRSHDAGKGW KQLQDLHGLG IIKSPYDNKV ALVLGEKKHW VTYDQGENWD SFETELPPSP
QVPVNWHAQD SKKILIHEIE NCFTAPCLGR TYYTTDGFKS KPKILIDDRR MCQWAKGAER
FLQGQDKHDD RILCITRGKY SDRSKDFRLL ISDNYFKDEE EPVMSSGRTV QGMANMAAVK
GYIVAAAKAD HSNELALYVT QDTETWHHAQ FGDHKIEEDA YTILESTNYS IQVDVMTSKY
VDMGNLYTSN SNGTHFTKNM EHTNRNEGGY VDFEKIANIQ GVVLVNTVDN WKQVEKSGQG
KKLKSRISFD DGRSFEKLTV KGKKDAELHL HSVTNLHNSG RVFSSPAPGI VMGVGNTGDY
LGKYTDGDLY VSDDAGLTWE LALEDAHKYE IGDQGSILVA VFDEGDTDEI RYSFKHGRKD
TWKKIKLDYK IRARELTTLP DSTSLKFMLY ASKKKDGGGR EHVIIHLDFT DMLKKCGDSD
FDDEWSVRKD ADGDPSCVMG HKQLFRRRKW DAECFVEEVF KDPTPNFKPC DCDEFRDYEC
DFGFTPTGEG KDKKCEPNDS FKLPKGACEG DAKTYKASSG WRKIPGDQCK GETERDKQVE
RECGDTERPP PKSDKITSEI TRFKGGEFLE QYYLEGNTQS DDDKDETVVM LTDERTAYIT
HDHGKKWKKA VDDEVVRIYP HQYDNNRVYF LTAGKKFYYS TDRGRRDSIR SHEAPVMPNK
ERLSIMQFHP KEESWIIWMG GKHCDKAGDK DCHTVAYVSQ KNGEDESWEP LVPYVKKCAF
VWREAGRSVK EEQIFCEQHT NEEMGAPLEL ISSEDWFKKK DVKFKSVVEF ATMSEFIVVA
TKADDGTLHL DASLDANTFA EAKFPPKFFD VHQTAYTVLD SSTHAVFLHV TVNPTRDQEY
GSIIKSNSNG TSYVMSLAAV NRNMEGYVDF EKMQGLEGVA VANVIVNVDE VNKGSKKKKQ
SRITHNDGAD WEPLQAPEKD SEGKAYECDV SDKYKCGLHI HGYTERADPR EMYSSPTAVG
MMLAVGNVGS ELSTFGEANT FMTTDAGITW TEIKKGTYAW EFGDQGSVIV IVRRGEDTDH
VYYSLDNGSK WNLYQFSDHK IRVEAITTVP SDTSLNFLLW GKDSKELVAV NLDFSGLPEF
SKKCELNENN PTSGDYDLWI PQHPLQKEEP QCLFGHVAQY HRKKRDAKCK NGQRIDQMHD
IARNCSCTRR DFECAYNYER DASGDCKLVA GLTLPEASAV CKDKNVKEYY TDVRFRRIPL
STCEGGQEFD KTGDPHPCPG FEEDFQKKHG IGGFSLFLAI VLPFAAAGGV GYYVWKHWDG
KFGRIRLGDG SGSGAFDSDA PWVKWPIAAV SGLVAVISAL PLLVGSVYRW AAGRMGGGGG
YGGYGRTYTS RSSFARGRGD YAVVDPDEGE LLGDDSDEEV
//