ID   A0A177DIU0_ALTAL        Unreviewed;       741 AA.
AC   A0A177DIU0;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   03-MAY-2023, entry version 23.
DE   SubName: Full=Cullin-2 {ECO:0000313|EMBL:OAG19416.1};
GN   ORFNames=CC77DRAFT_164741 {ECO:0000313|EMBL:OAG19416.1};
OS   Alternaria alternata (Alternaria rot fungus) (Torula alternata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC   Pleosporomycetidae; Pleosporales; Pleosporineae; Pleosporaceae; Alternaria;
OC   Alternaria sect. Alternaria; Alternaria alternata complex.
OX   NCBI_TaxID=5599 {ECO:0000313|EMBL:OAG19416.1, ECO:0000313|Proteomes:UP000077248};
RN   [1] {ECO:0000313|EMBL:OAG19416.1, ECO:0000313|Proteomes:UP000077248}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SRC1lrK2f {ECO:0000313|EMBL:OAG19416.1,
RC   ECO:0000313|Proteomes:UP000077248};
RG   DOE Joint Genome Institute;
RA   Zeiner C.A., Purvine S.O., Zink E.M., Wu S., Pasa-Tolic L., Chaput D.L.,
RA   Haridas S., Grigoriev I.V., Santelli C.M., Hansel C.M.;
RT   "Comparative analysis of secretome profiles of manganese(II)-oxidizing
RT   ascomycete fungi.";
RL   Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the cullin family.
CC       {ECO:0000256|ARBA:ARBA00006019, ECO:0000256|PROSITE-ProRule:PRU00330,
CC       ECO:0000256|RuleBase:RU003829}.
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DR   EMBL; KV441481; OAG19416.1; -; Genomic_DNA.
DR   RefSeq; XP_018384837.1; XM_018530377.1.
DR   AlphaFoldDB; A0A177DIU0; -.
DR   STRING; 5599.A0A177DIU0; -.
DR   GeneID; 29115971; -.
DR   KEGG; aalt:CC77DRAFT_164741; -.
DR   VEuPathDB; FungiDB:CC77DRAFT_164741; -.
DR   OMA; IREWDRY; -.
DR   OrthoDB; 5474206at2759; -.
DR   Proteomes; UP000077248; Unassembled WGS sequence.
DR   GO; GO:0031461; C:cullin-RING ubiquitin ligase complex; IEA:InterPro.
DR   GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:InterPro.
DR   GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR   Gene3D; 1.20.1310.10; Cullin Repeats; 4.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR045093; Cullin.
DR   InterPro; IPR016157; Cullin_CS.
DR   InterPro; IPR016158; Cullin_homology.
DR   InterPro; IPR036317; Cullin_homology_sf.
DR   InterPro; IPR001373; Cullin_N.
DR   InterPro; IPR019559; Cullin_neddylation_domain.
DR   InterPro; IPR016159; Cullin_repeat-like_dom_sf.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR11932; CULLIN; 1.
DR   PANTHER; PTHR11932:SF169; CULLIN-1; 1.
DR   Pfam; PF00888; Cullin; 1.
DR   Pfam; PF10557; Cullin_Nedd8; 1.
DR   SMART; SM00182; CULLIN; 1.
DR   SMART; SM00884; Cullin_Nedd8; 1.
DR   SUPFAM; SSF75632; Cullin homology domain; 1.
DR   SUPFAM; SSF74788; Cullin repeat-like; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS01256; CULLIN_1; 1.
DR   PROSITE; PS50069; CULLIN_2; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000077248};
KW   Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT   DOMAIN          377..616
FT                   /note="Cullin family profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50069"
SQ   SEQUENCE   741 AA;  85786 MW;  85CC392200D66D50 CRC64;
     MTNLREGVDM KTYMGLYTAI HNFCTAQKAV AGSSFHAANN RGGAHLLGED LYQHLIEYLK
     AHLAEVQAAS RQHVDEALLH FYIKEWNRYT TAGQYNNHLF RYLNRHWVKR EMDEGKKHIY
     DIYTLHLVRW KEDMFTGSQE SVMRSVLKLV EKQRNGETIE QSQIKSVVDS FVSLGLDEAD
     SSKSTLDVYK EYFEKPFLEA TAQYYDNESK QFLAENSVVE YMKKAEIRLE EEKERVPLYL
     LNEIMSPLMR TCEQSLITSH SQALREEFQI LLDHDKEEDL GRMYKLLARI PEGLDPLRLR
     FENHVRKAGL AAVDKIAQDG ENLEPKVYVE ALLEVHTQYQ ALVNKAFNGE SEFVRSLDNA
     CREFVNRNKI CKSGSNKSPE LLAKYTDTLL KRSNAKMSEE DDMEKLLTQI MTVFKYIEDK
     DVFQKFYSRM LAKRLVQTTS ASDDAETSMI SKLKEACGFE YTNKLQRMFQ DMQISKDLNT
     AFKEWQSNNL DDSDLKTSVD ASYHILGTGF WPLNPPTTPF TPPQLIVQTY DRFARFYNHK
     HQGRKLTWLW QLCKGEVKAN YCKVANLKTS PTFQVSTYQM AIMLLFNDSD TVSYDDIAES
     TKLNKETLDP SLGVFIKAKV LLAQPEGAKP ESGTSYKLNT GFKTKKVKMN LNIGIKSEQK
     AEAEDTHKTI EEDRKLLIQS AIVRIMKSRK KMKHQQLVSE TIQQIKNRFM PRVPDIKKCI
     DILLEKEYLE RLEADELGYL A
//