ID   A0A177HCA5_9RHOB        Unreviewed;       648 AA.
AC   A0A177HCA5;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   27-MAR-2024, entry version 19.
DE   SubName: Full=Adenylate and Guanylate cyclase catalytic domain protein {ECO:0000313|EMBL:OAH08663.1};
GN   ORFNames=pfor_5c0617 {ECO:0000313|EMBL:OAH08663.1};
OS   Rhodobacteraceae bacterium SB2.
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC   Paracoccaceae.
OX   NCBI_TaxID=1689867 {ECO:0000313|EMBL:OAH08663.1, ECO:0000313|Proteomes:UP000077333};
RN   [1] {ECO:0000313|EMBL:OAH08663.1, ECO:0000313|Proteomes:UP000077333}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SB2 {ECO:0000313|EMBL:OAH08663.1,
RC   ECO:0000313|Proteomes:UP000077333};
RA   Poehlein A., Billerbeck S., Voget S., Wemheuer B., Giebel H.-A.,
RA   Brinkhoff T., Daniel R., Simon M.;
RT   "A new prominent pelagic Roseobacter clade subcluster - CHAB-I-5:
RT   biogeography and genomic comparison to other roseobacters.";
RL   Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OAH08663.1}.
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DR   EMBL; LGRT01000006; OAH08663.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A177HCA5; -.
DR   STRING; 1689867.pfor_5c0617; -.
DR   PATRIC; fig|1689867.3.peg.3752; -.
DR   OrthoDB; 54411at2; -.
DR   Proteomes; UP000077333; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProt.
DR   GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd07302; CHD; 1.
DR   Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR43081; ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC-RELATED; 1.
DR   PANTHER; PTHR43081:SF1; PH-SENSITIVE ADENYLATE CYCLASE RV1264; 1.
DR   Pfam; PF00211; Guanylate_cyc; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   SUPFAM; SSF48452; TPR-like; 1.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000077333};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        189..211
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          12..126
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000259|PROSITE:PS50125"
SQ   SEQUENCE   648 AA;  73453 MW;  609378E9D9667453 CRC64;
     MSKSNLERKI AVIFVADVVQ YSKHMENDEV GTLRSYSACE EILLDLLKKH AGSVFNTAGD
     SVLVEFNSAV NAVECAVAFQ NKIQEKNSSD NDDVKLEFRI GINMGDVIVK DGNLLGDGVN
     IAARLEALSQ PNGICISKSV YDLVIPKTKM TFNDLGVQKV KQNEFHAFDI LLNPAQKRKI
     KSRTWGTRTL TSFMAIAVFT FMLVTSTLFF LNQNSSSGQN SDSVVLLVRP FDYVTSVDDK
     RFVADSMLTV FVAGLSGYEK LRVLSKNTSL LVEDENLTDT EVAQRYGANF ILNGSITVLG
     DDMRTSVELR NLTTNEIQFS DLINGQTQDL FDLQDKLVVS VLSSFDLEED KVRVSNEGIE
     TIEELRLLHF AAKEREKWTV GSYPAYADAV DKLFALNSEG YTQNVSQAWK YHYKMRLGLC
     RNEDKKNGST NCMIEAIKFV DKALELNPLK ADAYLAKSYF LSSLYLLNRD KERMMEWGGL
     EKAAEVAEKG YALISDDPYQ FGLAGEVFTF TNDFEKSANA FAKLFKLDDN PGDTFTQFYM
     ISSYLNNDLE KMRELAFRII ETNNSREVDT CTKPSCGNAA YAYLFLIYEA NQNNDQKKVD
     EYLQDFRSVR NQYTREMWMS RDNPARFIWK EQFEKITAMM DQLGWSSV
//