ID A0A177HCI9_9RHOB Unreviewed; 1131 AA.
AC A0A177HCI9;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
DE AltName: Full=DNA 3'-5' helicase II {ECO:0000256|ARBA:ARBA00034923};
GN Name=addA {ECO:0000313|EMBL:OAH08340.1};
GN ORFNames=pfor_12c1373 {ECO:0000313|EMBL:OAH08340.1};
OS Rhodobacteraceae bacterium SB2.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Paracoccaceae.
OX NCBI_TaxID=1689867 {ECO:0000313|EMBL:OAH08340.1, ECO:0000313|Proteomes:UP000077333};
RN [1] {ECO:0000313|EMBL:OAH08340.1, ECO:0000313|Proteomes:UP000077333}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SB2 {ECO:0000313|EMBL:OAH08340.1,
RC ECO:0000313|Proteomes:UP000077333};
RA Poehlein A., Billerbeck S., Voget S., Wemheuer B., Giebel H.-A.,
RA Brinkhoff T., Daniel R., Simon M.;
RT "A new prominent pelagic Roseobacter clade subcluster - CHAB-I-5:
RT biogeography and genomic comparison to other roseobacters.";
RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OAH08340.1}.
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DR EMBL; LGRT01000013; OAH08340.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A177HCI9; -.
DR STRING; 1689867.pfor_12c1373; -.
DR PATRIC; fig|1689867.3.peg.751; -.
DR OrthoDB; 9810135at2; -.
DR Proteomes; UP000077333; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR Gene3D; 3.90.320.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR InterPro; IPR014151; DNA_helicase_AddA.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011604; PDDEXK-like_dom_sf.
DR InterPro; IPR038726; PDDEXK_AddAB-type.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR NCBIfam; TIGR02784; addA_alphas; 1.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF12705; PDDEXK_1; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000077333}.
FT DOMAIN 4..479
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 496..784
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT REGION 934..958
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 25..32
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 1131 AA; 124432 MW; BB6D0256BF813E76 CRC64;
MSARDPASAR QLAAARPEIS TWLSANAGSG KTKVLTDRVA RLLLNGVLPE HILCLTYTKA
AASEMQNRLF ERLGAWSMRA DVALRDELQQ LGLETELDAA MLRKARTLFA RAIEAPGGLK
IQTIHSFCAA LLRRFPLEAG VSPQFHEMDE RASRLLAGSI LDDISASDQQ SVIGSVAAYC
NETDVMDLIA SVLKHRQLFA QGSAKAEIWG RLNLPVTLTG EALCAGVFTQ DAWGLIGTLV
SVLSTGSSTD QRNGEKLAKL SAPSLEALGL LEQLLLWGEG TTKNTPFSAK IDAFPTKALR
DGALQPHLPA LHALMARVED TRDQRLGLMA AQKTAVLYAF AAVFLPAYER EKQARGWLDF
DDLILKARGL LTDQAVADWV LYRLDGGIDH ILVDEAQDTS PIQWQVIEKL AQEFTSGQGA
RSNRGRTIFV VGDKKQSIYS FQGADPAEFD RMKADFAARL KPTDTPLFDA SLAHSFRSSS
AILALVDKLF APASGVSGAA GEQHLAFKTK MPGRVDLWPA LEAVEKQKDR SWERPVDLPD
QDNHLVQLAR HIAEEIDHMI TQKVAIPEEI GKTGRYHMRP VRAADFLILV QRRSDLFQEI
IRACKAQNLP IAGADRLKLG AEMAVKDLLA LLAFLATPED DLSLAVVLKS PLVGWDEQTL
FTLAQGRGRK FLWQVLRAAT DQHGHLIAML NDLLLQADFL RPYELLERVL THYAGRKLLL
GRLGQEAEDG LNALLGQAMA YERSEVPSLT GFLVWMQSDG LEIKRQADQD GNQIRVMTVH
GAKGLESPIV ILPDTAKRDA RLHDDLLVAQ DGAFWKVPRA EMPPRLRELR ERKLRAEEEE
RDRLLYVAIT RAEKWLIVAA AGDLGADQRA WYQKISLGVE ALAAQSQRFP TGMGRRFDYG
VWAPCSAEVE EEQSVPSLVL EEFFNEVAPP VPAQPKPLSP SDLGGEKSLQ SDAEETDEDA
KLRGLQIHKL LEVLPSLDPA LWPDMCSKIL DQAGLPASAE TFEALKAEVL GVLKTPDLQF
LFGFDALAEV ALSGPVAVLE NKQVYGIVDR LVVQEAAVWL VDFKSNAQVP ESPAEVPLGL
LRQMAAYAAV IARTYPDHQI IPALLWTKQA RLMPLPDALL ANVFSEPSLD L
//
