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Database: UniProt
Entry: A0A177HHZ4_9ACTN
LinkDB: A0A177HHZ4_9ACTN
Original site: A0A177HHZ4_9ACTN 
ID   A0A177HHZ4_9ACTN        Unreviewed;       580 AA.
AC   A0A177HHZ4;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   24-JAN-2024, entry version 18.
DE   SubName: Full=Pyruvate dehydrogenase {ECO:0000313|EMBL:OAH10007.1};
DE            EC=1.2.5.1 {ECO:0000313|EMBL:OAH10007.1};
GN   Name=poxB {ECO:0000313|EMBL:OAH10007.1};
GN   ORFNames=STSP_66770 {ECO:0000313|EMBL:OAH10007.1};
OS   Streptomyces jeddahensis.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1716141 {ECO:0000313|EMBL:OAH10007.1, ECO:0000313|Proteomes:UP000077381};
RN   [1] {ECO:0000313|EMBL:OAH10007.1, ECO:0000313|Proteomes:UP000077381}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=G25(2015) {ECO:0000313|Proteomes:UP000077381};
RA   Poehlein A., Roettig A., Hiessl S., Hauschild P., Schauer J., Madkour M.H.,
RA   Al-Ansari A.M., Almakishah N.H., Steinbuechel A., Daniel R.;
RT   "Genome sequence of Streptomyces sp. G25.";
RL   Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the TPP enzyme family.
CC       {ECO:0000256|ARBA:ARBA00007812, ECO:0000256|RuleBase:RU362132}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OAH10007.1}.
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DR   EMBL; LOHS01000163; OAH10007.1; -; Genomic_DNA.
DR   RefSeq; WP_067284661.1; NZ_LOHS01000163.1.
DR   AlphaFoldDB; A0A177HHZ4; -.
DR   STRING; 1716141.STSP_66770; -.
DR   PATRIC; fig|1716141.3.peg.7051; -.
DR   OrthoDB; 4959782at2; -.
DR   Proteomes; UP000077381; Unassembled WGS sequence.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR   GO; GO:0052737; F:pyruvate dehydrogenase (quinone) activity; IEA:UniProtKB-EC.
DR   GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR   CDD; cd02014; TPP_POX; 1.
DR   CDD; cd07039; TPP_PYR_POX; 1.
DR   Gene3D; 3.40.50.970; -; 2.
DR   Gene3D; 3.40.50.1220; TPP-binding domain; 1.
DR   InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR   InterPro; IPR047211; POXB-like.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR012000; Thiamin_PyroP_enz_cen_dom.
DR   InterPro; IPR012001; Thiamin_PyroP_enz_TPP-bd_dom.
DR   InterPro; IPR011766; TPP_enzyme_TPP-bd.
DR   InterPro; IPR047212; TPP_POXB-like.
DR   InterPro; IPR047210; TPP_PYR_POXB-like.
DR   PANTHER; PTHR42981; PYRUVATE DEHYDROGENASE [UBIQUINONE]; 1.
DR   PANTHER; PTHR42981:SF2; PYRUVATE DEHYDROGENASE [UBIQUINONE]; 1.
DR   Pfam; PF02775; TPP_enzyme_C; 1.
DR   Pfam; PF00205; TPP_enzyme_M; 1.
DR   Pfam; PF02776; TPP_enzyme_N; 1.
DR   SUPFAM; SSF52467; DHS-like NAD/FAD-binding domain; 1.
DR   SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
PE   3: Inferred from homology;
KW   Oxidoreductase {ECO:0000313|EMBL:OAH10007.1};
KW   Pyruvate {ECO:0000313|EMBL:OAH10007.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000077381};
KW   Thiamine pyrophosphate {ECO:0000256|RuleBase:RU362132}.
FT   DOMAIN          5..120
FT                   /note="Thiamine pyrophosphate enzyme N-terminal TPP-
FT                   binding"
FT                   /evidence="ECO:0000259|Pfam:PF02776"
FT   DOMAIN          192..320
FT                   /note="Thiamine pyrophosphate enzyme central"
FT                   /evidence="ECO:0000259|Pfam:PF00205"
FT   DOMAIN          383..529
FT                   /note="Thiamine pyrophosphate enzyme TPP-binding"
FT                   /evidence="ECO:0000259|Pfam:PF02775"
SQ   SEQUENCE   580 AA;  62700 MW;  15938E316D105FEB CRC64;
     MAKQNVAEQF VDILVRAGVK RLYGVVGDSL NPIVDAIRRN SAIDWVHVRH EETAAFAAGA
     EAQITGKLTA CAGSCGPGNL HLINGLYDAH RSMAPVLALA SHIPSSEIGL GYFQETHPDQ
     LFRECSHYSE LISSPKQMPR LLQTAIQNAV GRSGVSVVSL PGDIADQPAP DKAVEHAIVT
     TRPSVRPGDA EIDKLAEMID EAERVTLFCG SGTRGAHAEV MEFAEKIKSP VGHALRGKEW
     IQYDNPYDVG MSGLLGYGAA YEATHECDLL ILLGTDFPYN AFLPDDVKIA QIDVRPEHLG
     RRSKLDLAVW GDVKETLRCL TPRVAAKTNR RFLDKMLKKH ADALEGVVKA YTRKVEKHIP
     IHPEYVASVL DELAADDAVF TVDTGMCNVW AARYLTPNGR RRIIGSFSHG SMANALPQAI
     GAQFTDRSRQ IVSMSGDGGF SMLMGDLLTL VQHDLPVKIV LFNNSSLSMV ELEMLVAGLP
     SYGTANLNPD FAAVARACGV HGVRVEKPKQ LAGALKDAFS HKGPALVDIV TDPNALSIPP
     RISAEMVTGF ALSASKIVLE GGVGRMVQMA RSNLRNMPRP
//
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