ID A0A177HHZ4_9ACTN Unreviewed; 580 AA.
AC A0A177HHZ4;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE SubName: Full=Pyruvate dehydrogenase {ECO:0000313|EMBL:OAH10007.1};
DE EC=1.2.5.1 {ECO:0000313|EMBL:OAH10007.1};
GN Name=poxB {ECO:0000313|EMBL:OAH10007.1};
GN ORFNames=STSP_66770 {ECO:0000313|EMBL:OAH10007.1};
OS Streptomyces jeddahensis.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1716141 {ECO:0000313|EMBL:OAH10007.1, ECO:0000313|Proteomes:UP000077381};
RN [1] {ECO:0000313|EMBL:OAH10007.1, ECO:0000313|Proteomes:UP000077381}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=G25(2015) {ECO:0000313|Proteomes:UP000077381};
RA Poehlein A., Roettig A., Hiessl S., Hauschild P., Schauer J., Madkour M.H.,
RA Al-Ansari A.M., Almakishah N.H., Steinbuechel A., Daniel R.;
RT "Genome sequence of Streptomyces sp. G25.";
RL Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the TPP enzyme family.
CC {ECO:0000256|ARBA:ARBA00007812, ECO:0000256|RuleBase:RU362132}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OAH10007.1}.
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DR EMBL; LOHS01000163; OAH10007.1; -; Genomic_DNA.
DR RefSeq; WP_067284661.1; NZ_LOHS01000163.1.
DR AlphaFoldDB; A0A177HHZ4; -.
DR STRING; 1716141.STSP_66770; -.
DR PATRIC; fig|1716141.3.peg.7051; -.
DR OrthoDB; 4959782at2; -.
DR Proteomes; UP000077381; Unassembled WGS sequence.
DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR GO; GO:0052737; F:pyruvate dehydrogenase (quinone) activity; IEA:UniProtKB-EC.
DR GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR CDD; cd02014; TPP_POX; 1.
DR CDD; cd07039; TPP_PYR_POX; 1.
DR Gene3D; 3.40.50.970; -; 2.
DR Gene3D; 3.40.50.1220; TPP-binding domain; 1.
DR InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR InterPro; IPR047211; POXB-like.
DR InterPro; IPR029061; THDP-binding.
DR InterPro; IPR012000; Thiamin_PyroP_enz_cen_dom.
DR InterPro; IPR012001; Thiamin_PyroP_enz_TPP-bd_dom.
DR InterPro; IPR011766; TPP_enzyme_TPP-bd.
DR InterPro; IPR047212; TPP_POXB-like.
DR InterPro; IPR047210; TPP_PYR_POXB-like.
DR PANTHER; PTHR42981; PYRUVATE DEHYDROGENASE [UBIQUINONE]; 1.
DR PANTHER; PTHR42981:SF2; PYRUVATE DEHYDROGENASE [UBIQUINONE]; 1.
DR Pfam; PF02775; TPP_enzyme_C; 1.
DR Pfam; PF00205; TPP_enzyme_M; 1.
DR Pfam; PF02776; TPP_enzyme_N; 1.
DR SUPFAM; SSF52467; DHS-like NAD/FAD-binding domain; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000313|EMBL:OAH10007.1};
KW Pyruvate {ECO:0000313|EMBL:OAH10007.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000077381};
KW Thiamine pyrophosphate {ECO:0000256|RuleBase:RU362132}.
FT DOMAIN 5..120
FT /note="Thiamine pyrophosphate enzyme N-terminal TPP-
FT binding"
FT /evidence="ECO:0000259|Pfam:PF02776"
FT DOMAIN 192..320
FT /note="Thiamine pyrophosphate enzyme central"
FT /evidence="ECO:0000259|Pfam:PF00205"
FT DOMAIN 383..529
FT /note="Thiamine pyrophosphate enzyme TPP-binding"
FT /evidence="ECO:0000259|Pfam:PF02775"
SQ SEQUENCE 580 AA; 62700 MW; 15938E316D105FEB CRC64;
MAKQNVAEQF VDILVRAGVK RLYGVVGDSL NPIVDAIRRN SAIDWVHVRH EETAAFAAGA
EAQITGKLTA CAGSCGPGNL HLINGLYDAH RSMAPVLALA SHIPSSEIGL GYFQETHPDQ
LFRECSHYSE LISSPKQMPR LLQTAIQNAV GRSGVSVVSL PGDIADQPAP DKAVEHAIVT
TRPSVRPGDA EIDKLAEMID EAERVTLFCG SGTRGAHAEV MEFAEKIKSP VGHALRGKEW
IQYDNPYDVG MSGLLGYGAA YEATHECDLL ILLGTDFPYN AFLPDDVKIA QIDVRPEHLG
RRSKLDLAVW GDVKETLRCL TPRVAAKTNR RFLDKMLKKH ADALEGVVKA YTRKVEKHIP
IHPEYVASVL DELAADDAVF TVDTGMCNVW AARYLTPNGR RRIIGSFSHG SMANALPQAI
GAQFTDRSRQ IVSMSGDGGF SMLMGDLLTL VQHDLPVKIV LFNNSSLSMV ELEMLVAGLP
SYGTANLNPD FAAVARACGV HGVRVEKPKQ LAGALKDAFS HKGPALVDIV TDPNALSIPP
RISAEMVTGF ALSASKIVLE GGVGRMVQMA RSNLRNMPRP
//