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Database: UniProt
Entry: A0A177HML3_9ACTN
LinkDB: A0A177HML3_9ACTN
Original site: A0A177HML3_9ACTN 
ID   A0A177HML3_9ACTN        Unreviewed;       678 AA.
AC   A0A177HML3;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   05-JUL-2017, entry version 10.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA_2 {ECO:0000313|EMBL:OAH11840.1};
GN   Synonyms=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=STSP_48460 {ECO:0000313|EMBL:OAH11840.1};
OS   Streptomyces jeddahensis.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=1716141 {ECO:0000313|EMBL:OAH11840.1, ECO:0000313|Proteomes:UP000077381};
RN   [1] {ECO:0000313|EMBL:OAH11840.1, ECO:0000313|Proteomes:UP000077381}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=G25(2015) {ECO:0000313|Proteomes:UP000077381};
RA   Poehlein A., Roettig A., Hiessl S., Hauschild P., Schauer J.,
RA   Madkour M.H., Al-Ansari A.M., Almakishah N.H., Steinbuechel A.,
RA   Daniel R.;
RT   "Genome sequence of Streptomyces sp. G25.";
RL   Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731907}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:OAH11840.1}.
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DR   EMBL; LOHS01000101; OAH11840.1; -; Genomic_DNA.
DR   EnsemblBacteria; OAH11840; OAH11840; STSP_48460.
DR   PATRIC; fig|1716141.3.peg.5089; -.
DR   Proteomes; UP000077381; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-HAMAP.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000077381};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000077381}.
FT   DOMAIN      371    499       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      585    654       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     379    386       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   678 AA;  74472 MW;  93ABE75E783A4B79 CRC64;
     MADVPADLAA VWPRVLEQLL GEGRGQGVEA KDEHWIRRCQ PLALVADTAL LAVPNEFAKG
     VLEGRLAPVV SETLSRECGR PIRIAITVDD SAGEPPAPPS APSSTRQAGG PAPQRYEEPE
     LPSASGQGRD AYEGYGRTSA DDHLGGHRDQ LPGTRPDPLP TVRPAYPGDY QRPEPGAWPR
     PAQDEYGWQQ QRLGFPDRDP YATPSSAPQH DYRSSSGDRS AYEPGSPYES DRSPYEPDRQ
     RYDTERAPYD SERPQYDQQR SEYEQQRSEY EQRGRHDLPD RSSGPGGHGG RTGPGGHGGP
     GMHSGGPVGS GLPAPTGAPG PLAAQPAPAT GPGEPTARLN PKYLFDTFVI GASNRFAHAA
     AVAVAEAPAK AYNPLFIYGD SGLGKTHLLH AIGHYARSLY PGTRVRYVSS EEFTNEFINS
     IRDGKGDSFR KRYREMDILL VDDIQFLAEK ESTQEEFFHT FNTLHNANKQ IVLSSDRPPK
     QLVTLEDRLR NRFEWGLITD VQPPELETRI AILRKKAVQE QLNAPPEVLE FIASRISRNI
     RELEGALIRV TAFASLNRQP VDLGLTEIVL KDLIPGGEDS APEITATAIM AATADYFGLT
     VEDLCGSSRS RVLVTARQIA MYLCRELTDL SLPKIGAQFG GRDHTTVMHA DRKIRALMAE
     RRSIYNQVTE LTNRIKNG
//
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