ID   A0A177HZ21_9ACTN        Unreviewed;       633 AA.
AC   A0A177HZ21;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   24-JAN-2024, entry version 19.
DE   RecName: Full=exo-alpha-sialidase {ECO:0000256|ARBA:ARBA00012733};
DE            EC=3.2.1.18 {ECO:0000256|ARBA:ARBA00012733};
GN   Name=nedA_1 {ECO:0000313|EMBL:OAH15388.1};
GN   ORFNames=STSP_12510 {ECO:0000313|EMBL:OAH15388.1};
OS   Streptomyces jeddahensis.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1716141 {ECO:0000313|EMBL:OAH15388.1, ECO:0000313|Proteomes:UP000077381};
RN   [1] {ECO:0000313|EMBL:OAH15388.1, ECO:0000313|Proteomes:UP000077381}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=G25(2015) {ECO:0000313|Proteomes:UP000077381};
RA   Poehlein A., Roettig A., Hiessl S., Hauschild P., Schauer J., Madkour M.H.,
RA   Al-Ansari A.M., Almakishah N.H., Steinbuechel A., Daniel R.;
RT   "Genome sequence of Streptomyces sp. G25.";
RL   Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 33 family.
CC       {ECO:0000256|ARBA:ARBA00009348}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OAH15388.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; LOHS01000044; OAH15388.1; -; Genomic_DNA.
DR   RefSeq; WP_067273107.1; NZ_LOHS01000044.1.
DR   AlphaFoldDB; A0A177HZ21; -.
DR   STRING; 1716141.STSP_12510; -.
DR   PATRIC; fig|1716141.3.peg.1320; -.
DR   OrthoDB; 7294637at2; -.
DR   Proteomes; UP000077381; Unassembled WGS sequence.
DR   GO; GO:0052794; F:exo-alpha-(2->3)-sialidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0052795; F:exo-alpha-(2->6)-sialidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0052796; F:exo-alpha-(2->8)-sialidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0008152; P:metabolic process; IEA:UniProtKB-KW.
DR   CDD; cd00110; LamG; 1.
DR   CDD; cd15482; Sialidase_non-viral; 1.
DR   Gene3D; 2.120.10.10; -; 1.
DR   Gene3D; 2.60.120.200; -; 1.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR006558; LamG-like.
DR   InterPro; IPR001791; Laminin_G.
DR   InterPro; IPR011040; Sialidase.
DR   InterPro; IPR026856; Sialidase_fam.
DR   InterPro; IPR036278; Sialidase_sf.
DR   PANTHER; PTHR10628; SIALIDASE; 1.
DR   PANTHER; PTHR10628:SF25; SIALIDASE-1; 1.
DR   Pfam; PF13088; BNR_2; 1.
DR   Pfam; PF13385; Laminin_G_3; 1.
DR   SMART; SM00282; LamG; 1.
DR   SMART; SM00560; LamGL; 1.
DR   SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR   SUPFAM; SSF50939; Sialidases; 1.
PE   3: Inferred from homology;
KW   Glycosidase {ECO:0000313|EMBL:OAH15388.1};
KW   Hydrolase {ECO:0000313|EMBL:OAH15388.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000077381};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           26..633
FT                   /note="exo-alpha-sialidase"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5038793055"
FT   DOMAIN          462..601
FT                   /note="LamG-like jellyroll fold"
FT                   /evidence="ECO:0000259|SMART:SM00560"
FT   DOMAIN          462..596
FT                   /note="Laminin G"
FT                   /evidence="ECO:0000259|SMART:SM00282"
SQ   SEQUENCE   633 AA;  68163 MW;  D47933AA1765BA35 CRC64;
     MPSDVRVRLR SLRVLVVALS ALAVAAIPVP GNAQAGSAEA AAAGFEQQVL FKASQDPGYA
     CFRIPAVVKT TKGTLVAFAE GRVNDCSDAG DIDLVVKRST DGGRTWGPLQ VINEGAGDTH
     GNPAPVVDRR TGRIVVAETY NTGRTDGRNC SVPCDRTPHM QYSDDDGLTW SAPRDLSDEI
     LPDDWNSWYA TGPVHGIQLT HGKHAGRLVF GVNAETWNGS RVTANHAALM VSDDGGDHWR
     IGARDTWPIA DDGTFRQKPS EMTLTERADG TIYVSGREQD GTDLGHRTHT VSRDGGDSFA
     TPFRDIPDLY TPQVQGSTLR LGDRMLLACP GDPDRRRTMM IRSSYDGGRT WDSVDRGTVV
     TTDWSGYSDM VRIDDSTVGL MYEGGAVDAR DEIRFARFTE DWLKPRRGPD PTTDDLAPGA
     RRAAVLGGAE ETKGRFGGAV GFDGADDAVR LPYRDSLPLG SRDFTASLWF RYTATSGEQP
     LLWMGGVGTT QPQVWLRGEP ASDRITGLIT TRNGAAAPTS ASVRTTGAYN DGQWHHLALR
     RGGGQLTLSI DGTQFSTADV PGSVSRNSPF GVHIGQKLDS RAYFTGAIDD VRVYDRALSD
     AELDGLGTAG SRVSQATQDM VLWLPMDGIS GDR
//