ID A0A177NEM2_9GAMM Unreviewed; 215 AA.
AC A0A177NEM2;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=3-hexulose-6-phosphate synthase {ECO:0000256|ARBA:ARBA00012890};
DE EC=4.1.2.43 {ECO:0000256|ARBA:ARBA00012890};
GN ORFNames=A1356_22065 {ECO:0000313|EMBL:OAI30089.1}, A1507_13775
GN {ECO:0000313|EMBL:OAI15883.1}, MKLM6_0536
GN {ECO:0000313|EMBL:ATG88811.1};
OS Methylomonas koyamae.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Methylococcales;
OC Methylococcaceae; Methylomonas.
OX NCBI_TaxID=702114 {ECO:0000313|EMBL:OAI15883.1, ECO:0000313|Proteomes:UP000077857};
RN [1] {ECO:0000313|EMBL:OAI30089.1, ECO:0000313|Proteomes:UP000077734}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=R-49807 {ECO:0000313|EMBL:OAI30089.1,
RC ECO:0000313|Proteomes:UP000077734};
RA Heylen K., De Vos P., Vekeman B.;
RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:OAI15883.1, ECO:0000313|Proteomes:UP000077857}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=R-45378 {ECO:0000313|EMBL:OAI15883.1,
RC ECO:0000313|Proteomes:UP000077857};
RA Ploux O.;
RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:ATG88811.1, ECO:0000313|Proteomes:UP000242123}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LM6 {ECO:0000313|EMBL:ATG88811.1,
RC ECO:0000313|Proteomes:UP000242123};
RA Ehlers B., Leendertz F.H.;
RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=D-ribulose 5-phosphate + formaldehyde = D-arabino-hex-3-ulose
CC 6-phosphate; Xref=Rhea:RHEA:25201, ChEBI:CHEBI:16842,
CC ChEBI:CHEBI:58121, ChEBI:CHEBI:58542; EC=4.1.2.43;
CC Evidence={ECO:0000256|ARBA:ARBA00000718};
CC -!- PATHWAY: One-carbon metabolism; formaldehyde assimilation via RuMP
CC pathway; D-fructose 6-phosphate from D-ribulose 5-phosphate and
CC formaldehyde: step 1/2. {ECO:0000256|ARBA:ARBA00005014}.
CC -!- SIMILARITY: Belongs to the HPS/KGPDC family. HPS subfamily.
CC {ECO:0000256|ARBA:ARBA00006350}.
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DR EMBL; CP023669; ATG88811.1; -; Genomic_DNA.
DR EMBL; LUUJ01000080; OAI15883.1; -; Genomic_DNA.
DR EMBL; LUUL01000010; OAI30089.1; -; Genomic_DNA.
DR RefSeq; WP_064020374.1; NZ_LUUL01000010.1.
DR KEGG; mko:MKLM6_0536; -.
DR OrthoDB; 43475at2; -.
DR UniPathway; UPA00294; UER00434.
DR Proteomes; UP000077734; Unassembled WGS sequence.
DR Proteomes; UP000077857; Unassembled WGS sequence.
DR Proteomes; UP000242123; Chromosome.
DR GO; GO:0043801; F:hexulose-6-phosphate synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0004590; F:orotidine-5'-phosphate decarboxylase activity; IEA:InterPro.
DR GO; GO:0006207; P:'de novo' pyrimidine nucleobase biosynthetic process; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProtKB-KW.
DR GO; GO:0019647; P:formaldehyde assimilation via ribulose monophosphate cycle; IEA:UniProtKB-UniPathway.
DR GO; GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
DR CDD; cd04726; KGPDC_HPS; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR017553; 3-hexulose-6-phosphate_synth.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR041710; HPS/KGPDC.
DR InterPro; IPR001754; OMPdeCOase_dom.
DR InterPro; IPR011060; RibuloseP-bd_barrel.
DR NCBIfam; TIGR03128; RuMP_HxlA; 1.
DR PANTHER; PTHR35039; 3-KETO-L-GULONATE-6-PHOSPHATE DECARBOXYLASE SGBH-RELATED; 1.
DR PANTHER; PTHR35039:SF3; 3-KETO-L-GULONATE-6-PHOSPHATE DECARBOXYLASE SGBH-RELATED; 1.
DR Pfam; PF00215; OMPdecase; 1.
DR SMART; SM00934; OMPdecase; 1.
DR SUPFAM; SSF51366; Ribulose-phoshate binding barrel; 1.
PE 3: Inferred from homology;
KW Carbohydrate metabolism {ECO:0000256|ARBA:ARBA00023277};
KW Lyase {ECO:0000256|ARBA:ARBA00023239}.
FT DOMAIN 5..206
FT /note="Orotidine 5'-phosphate decarboxylase"
FT /evidence="ECO:0000259|SMART:SM00934"
SQ SEQUENCE 215 AA; 22302 MW; 1D57DECAC9EB2272 CRC64;
MARPLIQMAL DSLDFNQTVA LADQVAPYVD IFEIGTPCIK YNGVNLVKEL RNRYPDKLLL
VDLKTMDAGE YEAGAFYAAG ADICTVLGVS GLATIGGVIK AAKKHAAEVQ VDLINVPNKA
ECARESAKLG AQIMGVHTGL DAQAAGQTPF GDLNEVTSLG LNVRVSVAGG IKPATIDQTV
KAGANIIVVG AAIYGAPSPA EAAREIRELV DAAAV
//