ID A0A177R122_9PROT Unreviewed; 560 AA.
AC A0A177R122;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 24-JAN-2024, entry version 17.
DE SubName: Full=Thiamine pyrophosphate-binding protein {ECO:0000313|EMBL:OAI52846.1};
GN ORFNames=AYO46_04150 {ECO:0000313|EMBL:OAI52846.1};
OS Betaproteobacteria bacterium SCGC AG-212-J23.
OC Bacteria; Pseudomonadota; Betaproteobacteria.
OX NCBI_TaxID=1799662 {ECO:0000313|EMBL:OAI52846.1, ECO:0000313|Proteomes:UP000077532};
RN [1] {ECO:0000313|Proteomes:UP000077532}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SCGC AG-212-J23 {ECO:0000313|Proteomes:UP000077532};
RA Choi J., Stepanauskas R., Howe A.;
RL Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the TPP enzyme family.
CC {ECO:0000256|ARBA:ARBA00007812, ECO:0000256|RuleBase:RU362132}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OAI52846.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LSTF01000030; OAI52846.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A177R122; -.
DR Proteomes; UP000077532; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR GO; GO:0044281; P:small molecule metabolic process; IEA:UniProt.
DR CDD; cd00568; TPP_enzymes; 1.
DR CDD; cd07035; TPP_PYR_POX_like; 1.
DR Gene3D; 3.40.50.970; -; 2.
DR Gene3D; 3.40.50.1220; TPP-binding domain; 1.
DR InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR InterPro; IPR029061; THDP-binding.
DR InterPro; IPR012000; Thiamin_PyroP_enz_cen_dom.
DR InterPro; IPR012001; Thiamin_PyroP_enz_TPP-bd_dom.
DR InterPro; IPR045229; TPP_enz.
DR InterPro; IPR011766; TPP_enzyme_TPP-bd.
DR PANTHER; PTHR18968:SF120; ACETOLACTATE SYNTHASE LARGE SUBUNIT; 1.
DR PANTHER; PTHR18968; THIAMINE PYROPHOSPHATE ENZYMES; 1.
DR Pfam; PF02775; TPP_enzyme_C; 1.
DR Pfam; PF00205; TPP_enzyme_M; 1.
DR Pfam; PF02776; TPP_enzyme_N; 1.
DR SUPFAM; SSF52467; DHS-like NAD/FAD-binding domain; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000077532};
KW Thiamine pyrophosphate {ECO:0000256|RuleBase:RU362132}.
FT DOMAIN 9..124
FT /note="Thiamine pyrophosphate enzyme N-terminal TPP-
FT binding"
FT /evidence="ECO:0000259|Pfam:PF02776"
FT DOMAIN 196..333
FT /note="Thiamine pyrophosphate enzyme central"
FT /evidence="ECO:0000259|Pfam:PF00205"
FT DOMAIN 389..534
FT /note="Thiamine pyrophosphate enzyme TPP-binding"
FT /evidence="ECO:0000259|Pfam:PF02775"
SQ SEQUENCE 560 AA; 60734 MW; A843B74D22022980 CRC64;
MKSDLKTRHG GKILADALVA QGVKLAFGVP GESYLPVLDG MYDTRERLSF VICRQEGGAS
YMAEAYGKLT GEPGVLFVTR GPGATNGAIG VHTGLQDSTP MVVFIGQVPN EFAEREAFQE
IDYRRMYGQM AKWVGQIDRV ERIPEYVSHA FHTACAGRPG PVVLALPEDA LYGQAAVADV
PRYHKVRPAP SPQGISELNG LLQKAEKPFV LIGGGGWDRE ACLKLQKWVE ANGLAAGTSF
RCQDLFDNRS PNYAGDVGIG INPKLAERVK EADVLLVIGA RLGEMTTGAY SLVEAPLPRQ
TLVHVHGGAE ELGRVYRPSL AINSGMAQFV DALSPLSFSK PGWKADTEAL RKDYLQWTEP
RPMPGKLQYG EVIRWLSDNL PQDAIVAGGA GNFAGWLHRH FRYKGFRTQL GSTNGSMGYG
YPAAVAAKLA EPKRTVLGLC GDGDFLMTGQ EIATAAQYGA NFVALVVNNG IYGTIRMHQE
REYPGRVFGT DLKNPDFAAY ARAFGGHGET VERTEDFAPA FERASRSGKP ALIELKIDPD
AITPTMTLSA IREKALTSKR
//