ID A0A180ELU2_9BACT Unreviewed; 1137 AA.
AC A0A180ELU2;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 24-JAN-2024, entry version 30.
DE RecName: Full=Transcription-repair-coupling factor {ECO:0000256|HAMAP-Rule:MF_00969};
DE Short=TRCF {ECO:0000256|HAMAP-Rule:MF_00969};
DE EC=3.6.4.- {ECO:0000256|HAMAP-Rule:MF_00969};
GN Name=mfd {ECO:0000256|HAMAP-Rule:MF_00969};
GN ORFNames=A3850_006595 {ECO:0000313|EMBL:OAV44183.1};
OS Lewinella sp. 4G2.
OC Bacteria; Bacteroidota; Saprospiria; Saprospirales; Lewinellaceae;
OC Lewinella.
OX NCBI_TaxID=1803372 {ECO:0000313|EMBL:OAV44183.1, ECO:0000313|Proteomes:UP000076582};
RN [1] {ECO:0000313|EMBL:OAV44183.1, ECO:0000313|Proteomes:UP000076582}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=4G2 {ECO:0000313|EMBL:OAV44183.1,
RC ECO:0000313|Proteomes:UP000076582};
RA Wong S.-K., Yoshizawa S., Ogura Y., Tetsuya H., Nakajima Y., Hamasaki K.;
RT "Lewinella sp. 4G2 Genome sequencing.";
RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Couples transcription and DNA repair by recognizing RNA
CC polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent
CC release of RNAP and its truncated transcript from the DNA, and
CC recruitment of nucleotide excision repair machinery to the damaged
CC site. {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SIMILARITY: In the C-terminal section; belongs to the helicase family.
CC RecG subfamily. {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the UvrB family.
CC {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OAV44183.1}.
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DR EMBL; LVWJ02000014; OAV44183.1; -; Genomic_DNA.
DR RefSeq; WP_068215612.1; NZ_LVWJ02000014.1.
DR AlphaFoldDB; A0A180ELU2; -.
DR STRING; 1803372.A3850_006595; -.
DR OrthoDB; 9804325at2; -.
DR Proteomes; UP000076582; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR GO; GO:0000716; P:transcription-coupled nucleotide-excision repair, DNA damage recognition; IEA:UniProtKB-UniRule.
DR CDD; cd17991; DEXHc_TRCF; 1.
DR Gene3D; 2.40.10.170; -; 1.
DR Gene3D; 3.40.50.11180; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.30.2060.10; Penicillin-binding protein 1b domain; 1.
DR Gene3D; 3.90.1150.50; Transcription-repair-coupling factor, D7 domain; 1.
DR HAMAP; MF_00969; TRCF; 1.
DR InterPro; IPR003711; CarD-like/TRCF_RID.
DR InterPro; IPR036101; CarD-like/TRCF_RID_sf.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR004576; Mfd.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047112; RecG/Mfd.
DR InterPro; IPR037235; TRCF-like_C_D7.
DR InterPro; IPR005118; TRCF_C.
DR InterPro; IPR041471; UvrB_inter.
DR NCBIfam; TIGR00580; mfd; 1.
DR PANTHER; PTHR47964; ATP-DEPENDENT DNA HELICASE HOMOLOG RECG, CHLOROPLASTIC; 1.
DR PANTHER; PTHR47964:SF1; ATP-DEPENDENT DNA HELICASE HOMOLOG RECG, CHLOROPLASTIC; 1.
DR Pfam; PF02559; CarD_TRCF_RID; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF03461; TRCF; 1.
DR Pfam; PF17757; UvrB_inter; 1.
DR SMART; SM01058; CarD_TRCF; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00982; TRCF; 1.
DR SUPFAM; SSF141259; CarD-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 3.
DR SUPFAM; SSF143517; TRCF domain-like; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00969};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00969};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00969};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|HAMAP-Rule:MF_00969};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Reference proteome {ECO:0000313|Proteomes:UP000076582}.
FT DOMAIN 580..741
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 754..916
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 1137 AA; 129370 MW; 2673A0F9CA4CCFBF CRC64;
MPVTDPTQAI LQRYADSPRV AEIVGHVAEN PTARLQLKGL AGALESFLIA GCYRKAGGHT
LVVATDKEEA AYIQNTISAL LPKKQIRLLP DSFRRPLYFE VLDHTNVLLR TETINYLTHS
KSKGEIIVTY PEALFEQVVA PAELTSARIE LNKGEDLDVD TIIELLVEYG FSRQEFVYEP
GQFSIRGGIV DIFSYGNEYP YRIELFDEEI ESIRTFDPLE QLSKDNVEYV SIVPNINTKF
GRDQKTSIFE VLPENTTIWM RDFQLLIDKL NEAFEKANAF AQNLTVVDDL ELKQLFNDRA
FIRPGEVLQD VSGKPIVFFT DYKQTMKICK TIDCRAKPQP SFNKNMDLLI RNLLENTSGG
LKNYIFAGNP KQIERFYSIF KDLEASVRFE PINTAIHAGF IDPEMQAAFY TDHQIFERYH
RYRLKKGFTK DRALNLRMLR DLSPGDLVVH LDHGVGRFSG LEKLEVAGRT QESVRLIYKN
NDVLYVSINS LHKLSKFTGK EGALPRLDKI GGDAWRNMKA RTKKKMKDMA GELIKLYAKR
KASPGHAFPP DGHLQNEMEA NFMYEDTPDQ LKATNATKED MMKDHPMDRL ICGDVGFGKT
EIALRAAFKA AENGKQVAVL VPTTILALQH YRTFKERLEE FGIVVDYVNR FRTAKEKTQI
YKDLKEGKID IVIGTHAILS KRVGFKDLGL LVIDEEQKFG VKAKEKLRAM QVNVDTLTLT
ATPIPRTLQF SLMNARDMSV LRTAPLNRQP IHTEVRQFNE EVIKEAIESE VFRGGQAFFV
HNRVKSLNDM AVMLRKLCPE VQFAVAHGQM DPKNLEKTLI EFIDRKFEVL ICTNIIETGL
DISNANTIII NNSHQFGLSD LHQLRGRVGR SNKKAYCYLI APPLSVLTPE ARKRLRTLEE
HSDLGSGFDI AMKDLDIRGA GNLLGGEQSG FIADIGYETY QRILEEAVRE LKQGEFRDVF
AEQVHDVSNF VTDVTIETDV EMHIPTLYVE STQERLRLYQ ELDNLSTEEE LEVFAAGLVD
RFGKIPEEVE ELFDGLRLRW LCRELGFERL VLKNNKLICM FVEDAQSLYY ESPTFGALSE
IIAKDGVLRG LKLKQSPRRL SLIKENVKSL DIAQKVLNGL VDKLRMVLAD EKSEALA
//
