ID A0A180GRV3_PUCT1 Unreviewed; 1998 AA.
AC A0A180GRV3;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=1-phosphatidylinositol 4-kinase {ECO:0000256|ARBA:ARBA00012169};
DE EC=2.7.1.67 {ECO:0000256|ARBA:ARBA00012169};
GN ORFNames=PTTG_26594 {ECO:0000313|EMBL:OAV95557.1};
OS Puccinia triticina (isolate 1-1 / race 1 (BBBD)) (Brown leaf rust fungus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Pucciniomycotina;
OC Pucciniomycetes; Pucciniales; Pucciniaceae; Puccinia.
OX NCBI_TaxID=630390 {ECO:0000313|EMBL:OAV95557.1};
RN [1] {ECO:0000313|EMBL:OAV95557.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1-1 BBBD Race 1 {ECO:0000313|EMBL:OAV95557.1};
RG The Broad Institute Genome Sequencing Platform;
RA Ward D., Feldgarden M., Earl A., Young S.K., Zeng Q., Koehrsen M.,
RA Alvarado L., Berlin A., Bochicchio J., Borenstein D., Chapman S.B.,
RA Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J., Griggs A.,
RA Gujja S., Heilman E., Heiman D., Hepburn T., Howarth C., Jen D., Larson L.,
RA Lewis B., Mehta T., Park D., Pearson M., Roberts A., Saif S., Shea T.,
RA Shenoy N., Sisk P., Stolte C., Sykes S., Thomson T., Walk T., White J.,
RA Yandava C., Izard J., Baranova O.V., Blanton J.M., Tanner A.C.,
RA Dewhirst F.E., Haas B., Nusbaum C., Birren B.;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:OAV95557.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1-1 BBBD Race 1 {ECO:0000313|EMBL:OAV95557.1};
RA Cuomo C.A., Bakkeren G., Szabo L., Khalil H., Joly D., Goldberg J.,
RA Young S., Zeng Q., Fellers J.;
RT "Comparative analysis highlights variable genome content of wheat rusts and
RT divergence of the mating loci.";
RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. Type III PI4K
CC subfamily. {ECO:0000256|ARBA:ARBA00006209}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OAV95557.1}.
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DR EMBL; ADAS02000027; OAV95557.1; -; Genomic_DNA.
DR STRING; 630390.A0A180GRV3; -.
DR VEuPathDB; FungiDB:PTTG_26594; -.
DR OrthoDB; 147843at2759; -.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05167; PI4Kc_III_alpha; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR Gene3D; 1.25.40.70; Phosphatidylinositol 3-kinase, accessory domain (PIK); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR001263; PI3K_accessory_dom.
DR InterPro; IPR042236; PI3K_accessory_sf.
DR InterPro; IPR045495; PI4K_N.
DR InterPro; IPR015433; PI_Kinase.
DR PANTHER; PTHR10048:SF15; PHOSPHATIDYLINOSITOL 4-KINASE ALPHA; 1.
DR PANTHER; PTHR10048; PHOSPHATIDYLINOSITOL KINASE; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF00613; PI3Ka; 1.
DR Pfam; PF19274; PI4K_N; 2.
DR SMART; SM00145; PI3Ka; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
DR PROSITE; PS51545; PIK_HELICAL; 1.
PE 3: Inferred from homology;
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1424..1609
FT /note="PIK helical"
FT /evidence="ECO:0000259|PROSITE:PS51545"
FT DOMAIN 1682..1972
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
SQ SEQUENCE 1998 AA; 224262 MW; 8669853390383750 CRC64;
MDSLDLNVHS AILTSLAQCY ATSSPNDEPV AILTKLSALS LSNGTTKDSD TGDQHSSQPE
TFSNAASSVE IKITDSQAHY VVAYAAYISQ SAVSRTSISS VEIQRLCDMI RNLGCWSIEL
NLSTENAAEW PIVDEITYRL VLAMLEIGVL AKPLDREKLV GALCAFISEL GIGLSNGSPI
RIVTHFLPSL SGLRRALGSG FFPFTTTHLN QLFSSTVNCP FFPLSAQSKE HIESALAASS
ESNLTDYYRQ QIDHFKARYF MIGFPLSPSM IVFAGLQQFR NCLEQCLISV DLASSTEDSE
TESNDGGWTH LKHSASAKTG IGFSSDTVHD INSKMTVLFE DYYSLYQEEL DTGSPDDYTI
KIICEIIKLS SVCAVILDNV SDQVFDQMLT LHTEEAIIFH PAIQFAASES LIVLARNFPD
LLDRITETLR AYVSSTIPPT EMDANHGDEA PQAVLAAAHA LAVCLELKNS PDFTKAAIYA
LLNHVNTTQV DLTLQRPTNV EMTPPLQTSS KEQAESVSLD NQQLVSMNAL GTLLILLEKA
DQVELNSTIA PMLLLCLKGA SSNLEAAILN VVADLAVHVN QQTFEDVIST FTSLTKTAGV
ELGTTDSKEV FQLGIFRAQA KLSKNLCEKE DFSEIYLIEL LTLFIDKGQA IQSSHAGLPS
FPHLINQLAV LAPLIANLLQ PDSTYNPRKT ASLKISELFR NFWYVCVMFG FLSSTSSPRA
IVGSASGSPD WLIESLRQIA TKSPTLTHLT SINYLTTELD FNPILKFPDP VLTTPSKSKQ
NHAHVPSPHQ IALDQAKKQE LASLIPTHSG QIKSLNFIQT IFLLTTTRLE IFRAEDCRAS
NILEYFSHVS PDEVDVHNLF GCLVTISEKV LGAFVSSFQQ HAIRHTEVPH VHDQIPEILK
FTCHHSTRIR GIALRYCQDM IIAFPTLVCD FDTVLIMLEL ITLLRVSCEG EYEDEYSPKY
EFYSERADLT IQLIDDYAVR QQILNDLCRS VKNWLSIALA RAPLEMKSIF LRYLDAVTSP
ISMNPMGNIE MGKSIALEMA KMIPSNSQLS HLPSWGNWAP DLSSDLARSF SNRMFYNGQA
IHLSSLPDNE CQARLEECRA ELKQIMKQIT SGGKKTSITQ LSSALYRAGS HVIASPKPDL
ELLQRLVSLP IRMFTPLSVS LGLEVWTWLI DVKPEVQIKL IAEVMTMWNW THRQRKGLFS
NSLNSKNPLN QSIQFNPTDR DEMHHHLNSI KRMLKPHSIM LDFLSSRFQA ARYQNRSLVM
ATMQFLRKSF EHVSDWCKHP LSRELRIRML IFGFSICQGS RMEDNVEHLL RDLCYHASFD
WFSLTSSFGF GPNRLQHESE LRLLQELLEM VKVDVPVNAY HLSSMDLKAN LRLLPGRLSP
SAASLAHTDR NRLLQLFLEN EILRLMVWHN PLNDSKKGKD VEANISKLKG ESEVKLMVQT
AWSINPHLAL RLAERFKNIH IEEETRSLVK KFPHQARKVP EALDYFAQQF DPSIIPNLHQ
ILYWKKTPVM TALTYFLPQY DSDPVLLQYA MRVLEEHPVD VTFFYIPQVV QALRTDTLGY
VERFICETAQ VSQLFCHQII WNMKANTYKG DDATEADSLK PTLDRIMESI IGSLSGEAKT
FYETEFSFFD EVTSISKTLK DYLKKDKAEK KAKIAEELAK IKLLKGVYLP SNPDGTVVDI
DRTSGRPLQS HAKTPFMATF KVLREKTVHL DDDGNDVEES QDVTKSVETW QAAIFKVGDD
CRQDVLALQL IAIHKTMYES MCVDLHLVPY RVTATAPGCG VIDVIPDATS RDEMGRAKIN
DLTSFFIGKF GPVESIGFQT ARMNFIRSMA AYSVMCYLIQ IKDRHNGNIM IDGQGHITHI
DFGFLFDIGP GGIKFEPNSF KLTGEMIALM GGQNSAGFRA FQELVVKGFL ISRPFFKEIV
TCVKLMSDTQ LPSFKGESTI TKFIERFKPN LSDREAAIFM QSVIANAKQN GLSLLYDEFQ
WVTNEIPYTQ KDWITRPS
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