ID   A0A180GZX8_PUCT1        Unreviewed;      1455 AA.
AC   A0A180GZX8;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   24-JAN-2024, entry version 22.
DE   RecName: Full=Ras-GAP domain-containing protein {ECO:0000259|PROSITE:PS50018};
GN   ORFNames=PTTG_26002 {ECO:0000313|EMBL:OAV97573.1};
OS   Puccinia triticina (isolate 1-1 / race 1 (BBBD)) (Brown leaf rust fungus).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Pucciniomycotina;
OC   Pucciniomycetes; Pucciniales; Pucciniaceae; Puccinia.
OX   NCBI_TaxID=630390 {ECO:0000313|EMBL:OAV97573.1};
RN   [1] {ECO:0000313|EMBL:OAV97573.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1-1 BBBD Race 1 {ECO:0000313|EMBL:OAV97573.1};
RG   The Broad Institute Genome Sequencing Platform;
RA   Ward D., Feldgarden M., Earl A., Young S.K., Zeng Q., Koehrsen M.,
RA   Alvarado L., Berlin A., Bochicchio J., Borenstein D., Chapman S.B.,
RA   Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J., Griggs A.,
RA   Gujja S., Heilman E., Heiman D., Hepburn T., Howarth C., Jen D., Larson L.,
RA   Lewis B., Mehta T., Park D., Pearson M., Roberts A., Saif S., Shea T.,
RA   Shenoy N., Sisk P., Stolte C., Sykes S., Thomson T., Walk T., White J.,
RA   Yandava C., Izard J., Baranova O.V., Blanton J.M., Tanner A.C.,
RA   Dewhirst F.E., Haas B., Nusbaum C., Birren B.;
RL   Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:OAV97573.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1-1 BBBD Race 1 {ECO:0000313|EMBL:OAV97573.1};
RA   Cuomo C.A., Bakkeren G., Szabo L., Khalil H., Joly D., Goldberg J.,
RA   Young S., Zeng Q., Fellers J.;
RT   "Comparative analysis highlights variable genome content of wheat rusts and
RT   divergence of the mating loci.";
RL   Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OAV97573.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; ADAS02000012; OAV97573.1; -; Genomic_DNA.
DR   STRING; 630390.A0A180GZX8; -.
DR   VEuPathDB; FungiDB:PTTG_26002; -.
DR   OrthoDB; 1356198at2759; -.
DR   Gene3D; 3.40.525.10; CRAL-TRIO lipid binding domain; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR039360; Ras_GTPase.
DR   InterPro; IPR001936; RasGAP_dom.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   PANTHER; PTHR10194:SF142; NEUROFIBROMIN; 1.
DR   PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR   Pfam; PF00616; RasGAP; 1.
DR   SMART; SM00323; RasGAP; 1.
DR   SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR   PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE   4: Predicted;
FT   DOMAIN          833..1024
FT                   /note="Ras-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50018"
FT   REGION          242..265
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          510..533
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1455 AA;  163923 MW;  C5DC91B09ABE0771 CRC64;
     MNQCSARNIL SGSRNIRFSD QVSPSIVPAQ VSKICFFVSA SNWTIILGKI KNHIACWSGP
     EEFPDCSETR LLEFCSLNRH RLSSILRELS AQFVHLKRAA QSDIALALRR SVWNWIETYP
     NDLRKHLKAV KMTDVATTCC VNLCKAATFS PKTTAEGPGL RLLALDLVGD LNSRLLNPSK
     PCTNSEGVVE IPLMSEALAA LCKLNRHFVD TTLLEKCLSR NSFVPFQIAF IKACHKLASD
     PEIPPRSSFP SSSPHPHPED RLSEDEDDMA NWNVKLKELY PAIASSLRHV FMNAMLKTNQ
     FHILMRANSK LITGCDESGQ KTELVRALLN CEPRTHMTLA FFVPPSARHP HHQHQQQHTG
     RSAHELNSRL ASGHDIDPDD LEMFVYLTTL LLNNRNPRPV RQAVMTVLRA YHRPSSSPRP
     GAKLLPLGLR QARAIVGIAV LKALLKTWVF REEEREVLQL LKAYLDRFKE AVEWSERGHS
     PGFPFASESH AHEWLVFGHL LRLAVRSASA PSTNPTWPSS CAAPRSSSAS SRSTPPVLRL
     CGLDASLSAA QLSATLQGLP DNGKGLGGRV AQAKRAKLVM RTIASNSPII DPLWDKALRR
     WKLLSSLVGH RPFEDSSGNA GMYDCAPALG AISGEGVLEN TNAWISISGL LTSIASLHDP
     SHPKPRLPPL NHFIPPDLLH DRFYALPDRA RNVDRYIQEM VDLLVADDLR MREGVKDALG
     TELHTALFPI LLKHLKSIVA HFFEHKRAKP QSPFSHFIEQ AISMLRLFFE RIVEPLAEPV
     AEILWEVVKQ GGHLLPDLVK PVRPSGLDKI VDMITRPDLT LALAICKVCG SADFEEMTEV
     MLNIFDYRKG VIKFLKASIE REVAVTDHES TVFRGNLFTT RLLTIFARAQ GYDYLRNMLS
     NLLVGLANKP SEFSVDFNPH RASADDDEAA RNLEQVTEVF LNVIAVSWKK LPCAIREICH
     HIATTVQEKY PESLFTSIGG FIFLRFINPT IVSPEVIDLD LPNDTRKIRR SLVMITKVPQ
     ALSNNIRFSA REPAMKPLNP FMANNVYPMT RFLKNISSID EPGMVAEEGT ELQDELAPVP
     LDAADRYVLH RFLYENQEKL GAELKSVRPM EFKHWHDGSE RLTPTLGHEI WAEVVQTLQD
     IGPPPPPPPN ADPDLPLSHL NGPKYHAFLA KYELNRPPDP RIWQALFFEA PRSRLQTMPT
     FVFLTSRLKA EMCDLESFYL YILQAVDAID GPFALFLDCT AFTFANKISL PWFRQLIDAS
     PALPALHLAQ IWVYNANAIF QRYIRKLGAT EKQERRWSNL IRAVITLDEL AICLPNYEQV
     LPASLWNMFH DKRVVISHVT HLQQYQMQIP VVLHIGSKTL LIQSSKRLEL LADAKCTLNN
     VIRLKDIQEM QRLPPSNVHL DLGFIIKQYG SNVTMKFVSV NTDRIVETLT NTQTNLPLQP
     HPRYLLWLSS QWGHL
//