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Database: UniProt
Entry: A0A182C818_9BACT
LinkDB: A0A182C818_9BACT
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ID   A0A182C818_9BACT        Unreviewed;       445 AA.
AC   A0A182C818;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   27-SEP-2017, entry version 11.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724181};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377,
GN   ECO:0000313|EMBL:OAA31893.1};
GN   ORFNames=AT15_03455 {ECO:0000313|EMBL:OAA31893.1};
OS   Kosmotoga arenicorallina S304.
OC   Bacteria; Thermotogae; Kosmotogales; Kosmotogaceae; Kosmotoga.
OX   NCBI_TaxID=1453497 {ECO:0000313|EMBL:OAA31893.1, ECO:0000313|Proteomes:UP000077339};
RN   [1] {ECO:0000313|EMBL:OAA31893.1, ECO:0000313|Proteomes:UP000077339}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=S304 {ECO:0000313|EMBL:OAA31893.1,
RC   ECO:0000313|Proteomes:UP000077339};
RA   Pollo S.M., Charchuk R., Nesbo C.L.;
RT   "Kosmotoga genome sequencing.";
RL   Submitted (FEB-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724167}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:OAA31893.1}.
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DR   EMBL; JFHK01000002; OAA31893.1; -; Genomic_DNA.
DR   RefSeq; WP_068345748.1; NZ_JFHK01000002.1.
DR   EnsemblBacteria; OAA31893; OAA31893; AT15_03455.
DR   PATRIC; fig|1453497.3.peg.682; -.
DR   Proteomes; UP000077339; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000077339};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897}.
FT   DOMAIN      133    269       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      348    416       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     141    148       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   445 AA;  51220 MW;  B391049919CE4BCD CRC64;
     MSHRIIRILE KKLSRKTWDN WFTTLEIKEI TGDKVIFQVG NLFVKDWLQS RYGKVIHRAI
     HEALGKDLDF EIVYESPSKE VFESDEYKGP LVKKKPLILS ELNPEYTFEN FVVGTENRAL
     FEISQEICRK PGKFNPFFIF GGVGLGKTHL LQAIAHRVLE LFPEKKVLYI TSEQFMNDMI
     DAIKSGSIRD FRYQYRKKAD VLLIDDVQFL IGKEGTQREL FHTFNELHDA GKQIVICSDR
     TPDELNGFPD RLVSRFQMGM VMEILPPSLE TRYEIAKRLA RRESINLADD VAMELAHRID
     GNLRRLRGAI IKLIVQSSMY KEKIDLSFTR QIISSFQTDI TGVKPLTDVD RLLKAIEKVL
     GVSREEIKGT SRTKNVVKAR QLFIYMLKQE YGKSVQEIAE IVGKKHSTVI HSVKQISKSI
     LKDNKYIKGL VAKINNTVST DFAAS
//
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