ID A0A183A534_9TREM Unreviewed; 689 AA.
AC A0A183A534;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=guanylate cyclase {ECO:0000256|ARBA:ARBA00012202};
DE EC=4.6.1.2 {ECO:0000256|ARBA:ARBA00012202};
GN ORFNames=ECPE_LOCUS2069 {ECO:0000313|EMBL:VDP65326.1};
OS Echinostoma caproni.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Plagiorchiida; Echinostomata; Echinostomatoidea; Echinostomatidae;
OC Echinostoma.
OX NCBI_TaxID=27848 {ECO:0000313|Proteomes:UP000050740, ECO:0000313|WBParaSite:ECPE_0000206901-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:ECPE_0000206901-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (JUN-2016) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDP65326.1, ECO:0000313|Proteomes:UP000272942}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Egypt {ECO:0000313|EMBL:VDP65326.1,
RC ECO:0000313|Proteomes:UP000272942};
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the adenylyl cyclase class-4/guanylyl cyclase
CC family. {ECO:0000256|RuleBase:RU000405}.
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DR EMBL; UZAN01039400; VDP65326.1; -; Genomic_DNA.
DR WBParaSite; ECPE_0000206901-mRNA-1; ECPE_0000206901-mRNA-1; ECPE_0000206901.
DR Proteomes; UP000050740; Unplaced.
DR Proteomes; UP000272942; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0004383; F:guanylate cyclase activity; IEA:UniProtKB-EC.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07302; CHD; 1.
DR Gene3D; 6.10.250.780; -; 1.
DR Gene3D; 3.90.1520.10; H-NOX domain; 1.
DR Gene3D; 3.30.450.260; Haem NO binding associated domain; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR018297; A/G_cyclase_CS.
DR InterPro; IPR038158; H-NOX_domain_sf.
DR InterPro; IPR011644; Heme_NO-bd.
DR InterPro; IPR011645; HNOB_dom_associated.
DR InterPro; IPR042463; HNOB_dom_associated_sf.
DR InterPro; IPR024096; NO_sig/Golgi_transp_ligand-bd.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR PANTHER; PTHR45655; GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-2; 1.
DR PANTHER; PTHR45655:SF10; SOLUBLE GUANYLATE CYCLASE 88E; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR Pfam; PF07700; HNOB; 1.
DR Pfam; PF07701; HNOBA; 1.
DR SMART; SM00044; CYCc; 1.
DR SUPFAM; SSF111126; Ligand-binding domain in the NO signalling and Golgi transport; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR PROSITE; PS00452; GUANYLATE_CYCLASE_1; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU000405};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00023134};
KW Reference proteome {ECO:0000313|Proteomes:UP000272942}.
FT DOMAIN 411..541
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
FT REGION 270..289
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 347..381
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 689 AA; 78076 MW; 90E2C4C8520DC63C CRC64;
MYGLFLEGFK AYILSTFSEA VWRQVIVEAQ CETFDFEVRR DYDEDLLGRL FKATSKVTNL
SDYKIKYGMG KSFKDFFGFK EYQAVLRVLG RELRDFLNGL DNLHEFIRAT YPQIRPPSFF
CVNESRSGIT LKYQSKRDGM VPFFVGWMEN VSQMYFNIQM KITIIHSEKK ETSNITILRL
HFVNEAFPEV IEELSVPAHL FFEAFPFNFV FNRGMILINV GSSMIHALPD IVRRNLNEVF
VLERPHIELK WDDIMLHTNN IFQMVSNRAK PLDDDEENPT NDSNNPRKGC LRMRGQMKYM
VEWDAIVFLG TPIMEDVDAM WEVGLFLNDL SMHDSSRDMV LAGEQQSAEL KMALEQESEK
GKRLEESLRR LDEEVRRTDE LLYRMIPKAV AERLRSGASA IDTCETFENM TLLLSDVVGF
TTICSGLAPL EVVDLLNRLY SCFDGLTEKH KVYKVETIGD AYMIASGVPV RTKYHAPFIA
EMALDMVSGV QEVKDESKDP PESLRIRVGL HSGTVVAGVV GVKMPRYCLF GNTVTTAELM
EATSSPQRVQ ISKATFEKLS EYGVYDMTEK GTVQTKDGNT IYTYWLNGRP NEADCPKTAK
LCAHLAKERE LLADSNMAAN HSQTGEGWES VSASRGSSAR ALASKRSSLA AGGRASMGRL
SMIMDDKFAN KRKSLARVAQ MSRKISGAV
//
