ID   A0A183APU9_9TREM        Unreviewed;       985 AA.
AC   A0A183APU9;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   27-MAR-2024, entry version 30.
DE   SubName: Full=Helicase C-terminal domain-containing protein {ECO:0000313|WBParaSite:ECPE_0000901201-mRNA-1};
GN   ORFNames=ECPE_LOCUS8984 {ECO:0000313|EMBL:VDP84534.1};
OS   Echinostoma caproni.
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC   Digenea; Plagiorchiida; Echinostomata; Echinostomatoidea; Echinostomatidae;
OC   Echinostoma.
OX   NCBI_TaxID=27848 {ECO:0000313|Proteomes:UP000050740, ECO:0000313|WBParaSite:ECPE_0000901201-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:ECPE_0000901201-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (JUN-2016) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:VDP84534.1, ECO:0000313|Proteomes:UP000272942}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Egypt {ECO:0000313|EMBL:VDP84534.1,
RC   ECO:0000313|Proteomes:UP000272942};
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; UZAN01046743; VDP84534.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A183APU9; -.
DR   WBParaSite; ECPE_0000901201-mRNA-1; ECPE_0000901201-mRNA-1; ECPE_0000901201.
DR   Proteomes; UP000050740; Unplaced.
DR   Proteomes; UP000272942; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0003724; F:RNA helicase activity; IEA:InterPro.
DR   GO; GO:0006401; P:RNA catabolic process; IEA:InterPro.
DR   CDD; cd18795; SF2_C_Ski2; 1.
DR   Gene3D; 1.10.3380.30; -; 1.
DR   Gene3D; 2.40.30.300; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR048392; MTR4-like_stalk.
DR   InterPro; IPR025696; MTR4_beta-barrel.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR016438; SKI2-like.
DR   InterPro; IPR012961; Ski2/MTR4_C.
DR   PANTHER; PTHR12131; ATP-DEPENDENT RNA AND DNA HELICASE; 1.
DR   PANTHER; PTHR12131:SF7; EXOSOME RNA HELICASE MTR4; 1.
DR   Pfam; PF08148; DSHCT; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF21408; MTR4-like_stalk; 1.
DR   Pfam; PF13234; MTR4_beta-barrel; 1.
DR   PIRSF; PIRSF005198; Antiviral_helicase_SKI2; 3.
DR   SMART; SM01142; DSHCT; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Helicase {ECO:0000256|ARBA:ARBA00022806};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000272942}.
FT   DOMAIN          234..427
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51194"
SQ   SEQUENCE   985 AA;  109789 MW;  3A2845123E5D38E3 CRC64;
     MNAWDVDLED LESSFVLKSR PNSQDTLALP GKRVYESEPV RSDVKRTKKE GPKFETYVLN
     SGEGCLHEVV YPAGQSLKPL VPITEPARQY PFTLDSFQRE AVTCIENGQS VLVAAHTSAG
     KTVVADVGLV FLSATIPNAR QFAEWIVFLH KQPCHVVYTE YRPVPLQHYL FPCGGDGIHL
     VVNQKREFLE PNFQTAMSAL YKAAGNAASD TQMRGRRGGS IRSKPYCAKL VKLVMDQNLE
     PLIVFSFSKV DCEFYATQMN KMDFNTDKEK AAVDLIFKNA IDSLSAEDKR LPQVQILLPV
     LRRGVGIHHG GLLPILKEIV EILFAEGLIK VLYATETFAM GLNMPARTVL FTATRKFDGQ
     SFRLVSSGEY IQMSGRAGRR GKDDRGTVIL MLDDQISATE VRQLLSGQPD RLDSAFYLTN
     TMVLNLLRVE DINPELMLEK SFLQFQTKSS APPLNKRIKA LEAEIKAIQF PVDVDLDKLS
     SLVQLKDAKL SAERERWSIV LKAKSVIPFL QTGRVLRVHT VDDIDFGWAV LLHVEQPQTA
     PIRGQKSESS GTLLLHCLLE TLPLGAALDH DNEGMPGQRN TKPASVPLSM VEPAQSEFFA
     PDLDDKTLGS EKRTTVQVVS VPLSCVAELS SVCLKVRSVL TDSSGGFQAG KSADLMRRVS
     HLSESIRRHL WEGINRARDQ LDGVLPLLDP LKDMRIADPK LKQLMEMTHM LDARIALNPI
     SKRTDVDSLM DLFAHKATKL HELKVLQKHL ESQDSLVQLD ELHARKRLLR RLGFCQEDDV
     IAFKGRVACE ISSGDELMLT ELMLDGLFSN LTAAQLAGVL SCFVVERNAG KADKLILQPD
     MDNALKQIQT KARFLARAAA ECRVGASRTQ KEESDIKRTA IPEAGALLNN RVGILDDEQA
     YVDRFSGELM EVVRAWAEGV SFARLCELTH VFEGSVIRCM RRLEELLRQM HDAAKVAGNS
     ELENKFVQAM VMIKRDIVFA ASLYL
//