ID   A0A183BJJ6_GLOPA        Unreviewed;      1737 AA.
AC   A0A183BJJ6;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   RecName: Full=RNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00012494};
DE            EC=2.7.7.48 {ECO:0000256|ARBA:ARBA00012494};
OS   Globodera pallida (Potato cyst nematode).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Tylenchina; Tylenchomorpha; Tylenchoidea; Heteroderidae; Heteroderinae;
OC   Globodera.
OX   NCBI_TaxID=36090 {ECO:0000313|Proteomes:UP000050741, ECO:0000313|WBParaSite:GPLIN_000077500};
RN   [1] {ECO:0000313|Proteomes:UP000050741}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Lindley {ECO:0000313|Proteomes:UP000050741};
RA   Aslett M.;
RL   Submitted (DEC-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000050741}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Lindley {ECO:0000313|Proteomes:UP000050741};
RA   Cotton J.A., Lilley C.J., Jones L.M., Kikuchi T., Reid A.J., Thorpe P.,
RA   Tsai I.J., Beasley H., Blok V., Cock P.J.A., Van den Akker S.E.,
RA   Holroyd N., Hunt M., Mantelin S., Naghra H., Pain A., Palomares-Rius J.E.,
RA   Zarowiecki M., Berriman M., Jones J.T., Urwin P.E.;
RT   "The genome and life-stage specific transcriptomes of Globodera pallida
RT   elucidate key aspects of plant parasitism by a cyst nematode.";
RL   Submitted (MAY-2014) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|WBParaSite:GPLIN_000077500}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (JUN-2016) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC         RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC         COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC         EC=2.7.7.48; Evidence={ECO:0000256|ARBA:ARBA00024517};
CC   -!- SIMILARITY: Belongs to the RdRP family.
CC       {ECO:0000256|ARBA:ARBA00005762}.
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DR   WBParaSite; GPLIN_000077500; GPLIN_000077500; GPLIN_000077500.
DR   Proteomes; UP000050741; Unassembled WGS sequence.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003968; F:RNA-dependent RNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0031047; P:regulatory ncRNA-mediated gene silencing; IEA:UniProt.
DR   InterPro; IPR007855; RNA-dep_RNA_pol_euk-typ.
DR   PANTHER; PTHR23079; RNA-DEPENDENT RNA POLYMERASE; 1.
DR   PANTHER; PTHR23079:SF59; RNA-DIRECTED RNA POLYMERASE; 1.
DR   Pfam; PF05183; RdRP; 1.
PE   3: Inferred from homology;
KW   Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022484};
KW   RNA-binding {ECO:0000256|ARBA:ARBA00022884};
KW   RNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022484};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   REGION          215..313
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          327..379
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        218..266
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        280..313
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1737 AA;  197702 MW;  1E2F548D86BFC25E CRC64;
     MVPLMHFYRK EQSTNCDSII IPPSSLRVLR SRQKDLTSDW NCELDHLLHC KYDSRPEDIV
     EDAHGLLQNA LNDEHFVVEG NELALASVAQ PRVFNPTDEN GIEVEELEPR IEFYIGIIDK
     FKTIGCIFVL EHLMKCLRNH GKELQHLRYR VELRSPSGID MVPFKRHLSA SDTAQVGRIM
     FGNVLWHNQL YVHRRVKPNI RHMEEILGKD VRQLHISSRG DQQRSGVNRN IGRATGQSFD
     GCGSPTRSNG IPIPGKSVTT GAKFSPDNGG KVNGRHLCRK ESAQSLSSTP GTSSFDIKSP
     SPNSVDSSAS TLQPGVRPLL AQRDSGVALN GHDHDEDGIV PGWSTPPPLE EEGEGQTDDS
     PNMMKTKTRN AKKRMHKPKQ LQLADGRVIE LGMKAEFEHD RQMLSVTFFL PFQQNKNSWA
     LIDKYKLEFR YSSISQVLLS LKRKGRSRFV PRLMLRLQYP PTIWWADDVF GLRERITKTD
     KRFLRGMRVL GWPDPVEGVG SKAAVEEDIK DSPVVVLDLS SMEAKELSAL LSRFMVELKM
     KVELRNLHES LKERPKIVLA DALYDHPALM YWIQSLSTRG YVVMDHWTVE AECNDFFNNL
     ILINFEENPE QTLEALEMLA DKLLDRSEIK HHYGLGGMLR DIMAGVAKNG DYVTPLRDGY
     EHVKKVVITP SRIIPCGYEI LMGNRALRFD RDNYPPDKFL RVIFRDENWE RVRKHDTNNG
     RLLDQFVLER LVSGIEFGGQ VYSFVGTSNS QMRDGGCYFL QTDLEGVNDF RNRLGQFSLV
     PTIPKMMSRL GLCFTQGRAT DVDMRLRMLA WDFTGGLNTH EEPYTFSDGC GCLSVAAACQ
     ITAEIGLDVQ NPPSCYQFRY AGYKGVLAVN PMLDRNKEFF DAQGGEDQQL SREDFMAVDF
     LFRPSQKKFE VWQDYEEDCR LDVVKISAPT SVVMNKPFIN ILDQVSQMQS DRCHKRICTR
     VHALLDKHIF SVCATLTDEA FARRRLQDLP RLIEYNALNS VQFTREPFFR LVLRSAAKVA
     IHRVCQKLAI VIPPELGRMM FGVIDETGIL QHGQVFAQYT VDIDGAVTEH GWRNRKSKKR
     PSKKRILTGP VLVTKNPSIV GGDVRMLEAV DVAALHHLVD VLVFPRHGPR PHPDEMAGSD
     LDGDEYTLIW DEELALEGNQ PAADYSAPKG KSTPTADLSP EEYQQQMASF FVKYLSNDSV
     GQISNSHLAN SDLYGIDCDV CTTIAKKHSQ AVDFPKTGIP PAQLTNQWNE PVDLPPEKYE
     RTPDFMGKMS NEPYYVSNRL NAQLYRRIKA LSDFLFNTIS DESVRLPDMD ELLLSSEEHQ
     EYIELASEHY QKYAYSIRSL MDSYGIQCEG ELFSSSYSSL CNRVSDREND DMSFFTTSRV
     IEQRLWDIRQ AARKTFFASF GGDMETQTDD EGICNNPSDQ LKFLARAYYT IGYNSTSRKF
     LSFPWIASWE VLDAVRRSRI LSSLGQPGDS SGSGSRLFSG MFDSFGEHLT EHIEHYNSSR
     PTQFGEFSSR CFGDASSEED QAESAAIKQL LYRYVLRHEG LASLMFFSVE WAAHMGLFEQ
     SPLKEEHICL LLLGAGLMNQ PQNVLSSEER RPWLTETPVD WTESETAPRQ AVTRPGRRFS
     SFVESLASRH FEQMLCLDFT HLGLESALMF GGEWRELHRI ALKTYYSLVF MDCSQHVLPP
     IDEQNSDCEL RPDDDHDQAT QPIIKQGDVF VIELPCRMES EYMLLSTKMR VQLCAQR
//