ID   A0A183CA45_GLOPA        Unreviewed;       643 AA.
AC   A0A183CA45;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   RecName: Full=glutaminase {ECO:0000256|ARBA:ARBA00012918};
DE            EC=3.5.1.2 {ECO:0000256|ARBA:ARBA00012918};
OS   Globodera pallida (Potato cyst nematode).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Tylenchina; Tylenchomorpha; Tylenchoidea; Heteroderidae; Heteroderinae;
OC   Globodera.
OX   NCBI_TaxID=36090 {ECO:0000313|Proteomes:UP000050741, ECO:0000313|WBParaSite:GPLIN_000974400};
RN   [1] {ECO:0000313|Proteomes:UP000050741}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Lindley {ECO:0000313|Proteomes:UP000050741};
RA   Aslett M.;
RL   Submitted (DEC-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000050741}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Lindley {ECO:0000313|Proteomes:UP000050741};
RA   Cotton J.A., Lilley C.J., Jones L.M., Kikuchi T., Reid A.J., Thorpe P.,
RA   Tsai I.J., Beasley H., Blok V., Cock P.J.A., Van den Akker S.E.,
RA   Holroyd N., Hunt M., Mantelin S., Naghra H., Pain A., Palomares-Rius J.E.,
RA   Zarowiecki M., Berriman M., Jones J.T., Urwin P.E.;
RT   "The genome and life-stage specific transcriptomes of Globodera pallida
RT   elucidate key aspects of plant parasitism by a cyst nematode.";
RL   Submitted (MAY-2014) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|WBParaSite:GPLIN_000974400}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (JUN-2016) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + L-glutamine = L-glutamate + NH4(+);
CC         Xref=Rhea:RHEA:15889, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938,
CC         ChEBI:CHEBI:29985, ChEBI:CHEBI:58359; EC=3.5.1.2;
CC         Evidence={ECO:0000256|ARBA:ARBA00001062};
CC   -!- SIMILARITY: Belongs to the glutaminase family.
CC       {ECO:0000256|ARBA:ARBA00011076}.
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DR   AlphaFoldDB; A0A183CA45; -.
DR   WBParaSite; GPLIN_000974400; GPLIN_000974400; GPLIN_000974400.
DR   Proteomes; UP000050741; Unassembled WGS sequence.
DR   GO; GO:0004359; F:glutaminase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006541; P:glutamine metabolic process; IEA:InterPro.
DR   Gene3D; 1.10.238.210; -; 1.
DR   Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR   InterPro; IPR012338; Beta-lactam/transpept-like.
DR   InterPro; IPR015868; Glutaminase.
DR   InterPro; IPR041541; Glutaminase_EF-hand.
DR   NCBIfam; TIGR03814; Gln_ase; 1.
DR   PANTHER; PTHR12544; GLUTAMINASE; 1.
DR   PANTHER; PTHR12544:SF7; GLUTAMINASE 2-RELATED; 1.
DR   Pfam; PF17959; EF-hand_14; 1.
DR   Pfam; PF04960; Glutaminase; 1.
DR   SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
PE   3: Inferred from homology;
KW   ANK repeat {ECO:0000256|ARBA:ARBA00023043};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          63..155
FT                   /note="Glutaminase EF-hand"
FT                   /evidence="ECO:0000259|Pfam:PF17959"
FT   REGION          558..591
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        566..580
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   643 AA;  72452 MW;  F4DCA6619BDFD380 CRC64;
     MMAPTPINPV NGHAQPMRRK ISSNTLEQFA PLKDERRLSL QSAIQKTKEG LDNPFACDEQ
     SPEELIYNLF KIPNKSDASI GKLIMVLKNY GLQENDPRLA PMMRKIREIE NEKEERMNEA
     RDPKHWKMSH NDFTRVISES LSLIVQTLQN DLIVPAWAHF CSIIKEIYTE CIPITDGKVA
     NYIPQLARMS PNYWGVSICT VDGQRISFGD SNVPFCVQSV SKALNYSIAA SEMGAEYVHQ
     YVGQEPSGRL FNEICLDPNN KPHNPMVNSG AIIVTSLIRA QLNMADRFEY MINEYKKMAG
     GEYVGFNNAV FLSEAATADR NFALAYFMKE NGCFPEESKH TALKETLDFY FQLCSLEVNC
     EGAAVIAATL ANGGVCPLTG ERCIGSRPCR DVLSLMNSCG MYDYSGQFAF HVGLPAKSGV
     SGVMIVQADS FRNFCCHHGH HYPQDHQHKN NIVDSKNTEQ YNNPQQQQNN IHNIENYEPA
     QVQTGGSVND SESGEIGIFE YYHDVRDEQK VMGEDVDSLD ELHQPRDNSL QYSEMSDAES
     HGALSTAEPV WSEALPHEQH QMKHERGQLQ QQQTVEQVSS AGSDEDEEED ILTDSNDVRK
     MACMLSPSAY CQNNLAQQKM QKLPMPSNKH HRICQQINHQ FSI
//