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Database: UniProt
Entry: A0A183G579_HELBK
LinkDB: A0A183G579_HELBK
Original site: A0A183G579_HELBK 
ID   A0A183G579_HELBK        Unreviewed;       912 AA.
AC   A0A183G579;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   20-DEC-2017, entry version 9.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
OS   Heligmosomoides polygyrus bakeri (Parasitic nematode) (Heligmosomoides
OS   bakeri).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Strongylida; Trichostrongyloidea; Heligmosomatidae; Heligmosomoides.
OX   NCBI_TaxID=375939 {ECO:0000313|Proteomes:UP000050761, ECO:0000313|WBParaSite:HPBE_0001674101-mRNA-1};
RN   [1] {ECO:0000313|Proteomes:UP000050761, ECO:0000313|WBParaSite:HPBE_0001674101-mRNA-1}
RP   NUCLEOTIDE SEQUENCE.
RG   Helminth Genomes Consortium;
RL   Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|WBParaSite:HPBE_0001674101-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (JUN-2016) to UniProtKB.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
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DR   WBParaSite; HPBE_0001674101-mRNA-1; HPBE_0001674101-mRNA-1; HPBE_0001674101.
DR   Proteomes; UP000050761; Genome Assembly.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 4.
DR   Pfam; PF01496; V_ATPase_I; 4.
DR   PIRSF; PIRSF001293; ATP6V0A1; 4.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000050761};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000050761};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    338    362       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    383    401       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    475    494       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    515    534       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    597    615       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    635    656       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    777    798       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    839    864       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED       58     78       {ECO:0000256|SAM:Coils}.
FT   COILED      101    135       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   912 AA;  104673 MW;  6682D3C31D25B01E CRC64;
     MSEPEPDQPG IYRSEQMTLA QLFLQSEAAY QCVAELGELG LVQFRDLNPD TSAFQRKYVN
     EVRRCDEMER KLRYLEREIK KDQIPMLDTG ENPDAPQPRE MIDLEATFEK LENELREVNR
     NEETLKKNFS ELTELKHILR KTQTFFEEGE PVNKTVFIIF FQGDQLKTKV KKICEGFRAT
     LYPCPDTPQE RREMSIGVMT RIEDLKTVLG QTQDHRHRVL VAASKNVRMW LTKVRKIKSI
     YHTLNLFNID VTHKCLIAEC WCPVSELDRI KMALKRGTEE SGSQVPSILN RMDTTEAPPT
     YHKTNKFTRG FQNIVDAYGI ATYREINPAP YTIISFPFLF AVMFGDMGHG AIMLCAALFF
     ILKEKQLEAA RIKDEIFQTF FGGRYLIFLM GVFSIYTGFL YNDVFSKSMN IFGSGWTNCY
     DLNEAKKLGY DEEKQLMLIP ENAYDSAGGP YPIGVDPIWN LAESNKLTFL NSMKMKISVI
     FGVTQMTFGV LLSYQNYKYF KSRLDINFMF IPQMVFLSCI FIYLCLEIVV KWIFYTAGPQ
     ESIFGYKYPG SNCAPSLLIG LINMFQLKEY GKGFVDDDGK QMFQCQLNSW YPGQHTFQSV
     LFIAAIVCVP VMLFAKPYLL WKEQKKQEEA GHRHLGVVGK VLVLLAVVQV PVMLFVKPFV
     LRSRSRSAEA LYYSLSDESV RADMNGDDAE VVHTEPKMSG TTSGSGGDHG HGSEKFDLGE
     TMVYQAIHTI EFVLGTISHT ASYLRLWALS LAHAQLSDVL WTMVFRHSFR LDGYYGIIAT
     YLLFFIFGSL SVFILVLMEG LSAFLHALRL HWSNLNVTVL ELSDVLWTMV FRHSFRLDGY
     YGIIATYLLF FIFGSLSVFI LVLMEGLSAF LHALRLHWVE FQSKFYGGLG HAFTPFSFEK
     ILEEERQAED SL
//
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