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Database: UniProt
Entry: A0A183H1U8_9BILA
LinkDB: A0A183H1U8_9BILA
Original site: A0A183H1U8_9BILA 
ID   A0A183H1U8_9BILA        Unreviewed;       889 AA.
AC   A0A183H1U8;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   25-OCT-2017, entry version 5.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   ORFNames=X798_02358 {ECO:0000313|EMBL:OZC10609.1};
OS   Onchocerca flexuosa.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Spirurida;
OC   Filarioidea; Onchocercidae; Onchocerca.
OX   NCBI_TaxID=387005 {ECO:0000313|Proteomes:UP000050787, ECO:0000313|WBParaSite:OFLC_0000145701-mRNA-1};
RN   [1] {ECO:0000313|Proteomes:UP000050787, ECO:0000313|WBParaSite:OFLC_0000145701-mRNA-1}
RP   NUCLEOTIDE SEQUENCE.
RG   Helminth Genomes Consortium;
RL   Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:OZC10609.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Red Deer {ECO:0000313|EMBL:OZC10609.1};
RA   Mitreva M.;
RT   "Draft genome of the nematode, Onchocerca flexuosa.";
RL   Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|WBParaSite:OFLC_0000145701-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (JUN-2016) to UniProtKB.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
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DR   EMBL; KZ269985; OZC10609.1; -; Genomic_DNA.
DR   WBParaSite; OFLC_0000145701-mRNA-1; OFLC_0000145701-mRNA-1; OFLC_0000145701.
DR   Proteomes; UP000050787; Genome assembly.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000050787};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000050787};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    406    430       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    450    470       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    550    573       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    579    603       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    615    639       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    684    703       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    829    853       Helical. {ECO:0000256|RuleBase:RU361189}.
SQ   SEQUENCE   889 AA;  102698 MW;  19F159E09634F177 CRC64;
     MGSLYRSEQM RFCQMIVQKD AAFSCVAELG KHPYVQFKDL NADVNPFQRM YLRDIQRFEE
     LERKLRFLDA QIRKDDIEVN DDVSTDGTYE VLAPHELNQL EGTLVDLERD VIDMNSNNIL
     LKQSYLELKE WEAILEKTDH FFEEGISDVA MHEIEAMEEE SALALKRAKE PIGFLAGIIN
     RDRVNAFEKV LWRACHKTAF VRTTDIEEEL ENPDSGEMCT KSVFLVFYKG DRLRIIIERV
     CEGFKAKIYN NCPKNSKDRH AAARDVKARI SDMRTVLGQT QEHRYKVLQA ASSSVKQWQK
     EVRMQKSVYY TLNLFTFDAI GKFFIAECWV PYADLENVRL ALEEGVRKSG SSVRPVLNLL
     ETTEEPPTYN RVNKFTRVFQ AIVDSYGTAS YLEINPAPYT IITFPFLFSC MFGDLGHGIL
     MLLAGLWMVL REKNLEARNI KDEVILNTFY GGRYIILLMG IFSVHAGFLY NDVFAKSFNL
     FGSKWRNPFP NTEIESWDSE SIRLHKEILI DLPPSRSYMH DHGPYWFGVD PIWNLAENRL
     NFSNSLKMKL SVILGIAQMT FGVFLSLLNY IYFKSKIEIF TVFIPQILFM FCIFIYLCAQ
     IIVKWLFFWV REEYIFGLLY PGSSCAPSLL IGLISMFMFK DRPLGFVDEM EIISVNDGHV
     TYANWPNCYL SQWYPGQANE FQSTFEAILV IIAVICVPIM LFGKPIHFLL HHKKKNVVSD
     NSVVWQNQEN DKAEITLNEN GSSLNKRNWE ETTSNNEYEE ESFADVMVHQ AIHTIEYVLG
     CVSHTASYLR LWALSLAHAQ LSEVLWEMVL VQAFGISGIA GYFTAYFIFF AFGILTVSIL
     VLMEGLSAFL HALRLHWVEF QSKFYLGLGY PFVPFYFKDV LLKASAGEK
//
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