ID   A0A183H934_9BILA        Unreviewed;       276 AA.
AC   A0A183H934;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   22-FEB-2023, entry version 25.
DE   SubName: Full=FYVE zinc finger {ECO:0000313|WBParaSite:OFLC_0000399501-mRNA-1};
GN   ORFNames=OFLC_LOCUS3996 {ECO:0000313|EMBL:VDO38540.1};
OS   Onchocerca flexuosa.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Onchocerca.
OX   NCBI_TaxID=387005 {ECO:0000313|Proteomes:UP000050787, ECO:0000313|WBParaSite:OFLC_0000399501-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:OFLC_0000399501-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (JUN-2016) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:VDO38540.1, ECO:0000313|Proteomes:UP000267606}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; UZAJ01002877; VDO38540.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A183H934; -.
DR   STRING; 387005.A0A183H934; -.
DR   WBParaSite; OFLC_0000399501-mRNA-1; OFLC_0000399501-mRNA-1; OFLC_0000399501.
DR   Proteomes; UP000050787; Unplaced.
DR   Proteomes; UP000267606; Unassembled WGS sequence.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006897; P:endocytosis; IEA:InterPro.
DR   Gene3D; 1.20.5.730; Single helix bin; 1.
DR   Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR   InterPro; IPR003914; Rabaptin.
DR   InterPro; IPR015390; Rabaptin_Rab5-bd_dom.
DR   InterPro; IPR000306; Znf_FYVE.
DR   InterPro; IPR017455; Znf_FYVE-rel.
DR   InterPro; IPR011011; Znf_FYVE_PHD.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   PANTHER; PTHR31179:SF7; FYVE-TYPE DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR31179; RAB GTPASE-BINDING EFFECTOR PROTEIN; 1.
DR   Pfam; PF01363; FYVE; 1.
DR   Pfam; PF09311; Rab5-bind; 1.
DR   SMART; SM00064; FYVE; 1.
DR   SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR   SUPFAM; SSF103652; G protein-binding domain; 1.
DR   PROSITE; PS50178; ZF_FYVE; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW   ProRule:PRU00091}.
FT   DOMAIN          217..275
FT                   /note="FYVE-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50178"
FT   COILED          112..198
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   276 AA;  32222 MW;  0E6476454A4B8F6E CRC64;
     MMNKDVRNLS SRYLKLLGAN RKCSTEMRDQ TIELPQDIDQ LQFLCLQLRE ELIETRAAKE
     HAEVVLRDEI TTLETQRKED EIEKRRIEDV YTERVNGVSQ ELGFARSQLD SMKDASSKVE
     EMNKRMTEYR KVIEDLEKQL QSVQKERADL EMTVAFYKQK CAALQQELDT SETVQKDFVK
     LSQNLQIELE KIRQAEQSVF VNDAFIQVLK EVRWQFDEDV HACNQCESNF SKNRIKLHCC
     HCGKIFCSIC LTATIPSGPH RRPAKVCQVC HTLLSR
//