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Database: UniProt
Entry: A0A183HBY8_9BILA
LinkDB: A0A183HBY8_9BILA
Original site: A0A183HBY8_9BILA 
ID   A0A183HBY8_9BILA        Unreviewed;       475 AA.
AC   A0A183HBY8;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   15-FEB-2017, entry version 4.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
OS   Onchocerca flexuosa.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Spirurida;
OC   Filarioidea; Onchocercidae; Onchocerca.
OX   NCBI_TaxID=387005 {ECO:0000313|Proteomes:UP000050787, ECO:0000313|WBParaSite:OFLC_0000499901-mRNA-1};
RN   [1] {ECO:0000313|Proteomes:UP000050787, ECO:0000313|WBParaSite:OFLC_0000499901-mRNA-1}
RP   NUCLEOTIDE SEQUENCE.
RG   Helminth Genomes Consortium;
RL   Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|WBParaSite:OFLC_0000499901-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (JUN-2016) to UniProtKB.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
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DR   WBParaSite; OFLC_0000499901-mRNA-1; OFLC_0000499901-mRNA-1; OFLC_0000499901.
DR   Proteomes; UP000050787; Genome assembly.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0033179; C:proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000050787};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000050787};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    254    278       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    299    317       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    354    371       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    405    422       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    434    454       Helical. {ECO:0000256|RuleBase:RU361189}.
SQ   SEQUENCE   475 AA;  55213 MW;  172B679BE7E675CE CRC64;
     VESFFILIGH FIINKNSKLC SFVAGVIHRE RLPAFERLLW RACRGNVFLR QSEIAEPLID
     PTTGDPVINT VFIIFFQGDQ LKTRVKKICE GFRATLYPCP DTPQERREMS IGVMTRIEDL
     KTVLGQTQDH RHRVLVAASK NVRMWLTKVR KIKSIYHTLN LFNLDVTQKC LIAECWCPVA
     DLNRIQLALK RGTEESGSTV PSILNRMSDI TEAPPTFHRV NKFTRGFQNI VDAYGIASYR
     EINPAPYTMI TFPFIFAVMF GDCGHGLIML LCALFFIYRE KRLESARIND EIFQTFFNGR
     YVIFLMGCFS IYTGLIYNDV YSKSFNLFGS SWRNIYSNLN KLEYERELML TPQWAYYNVV
     GHLYIFLRFF LKLFSVGPYP IGVDPIWNLA ESNKLSFLNS MKMKMSVIIG IAQMTFGVML
     SYENYKYFNS RLDILYMFIP QMLFLGCIFI YLCMQIVFKW LLFSAKVGIL VFLNV
//
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