ID A0A183I1J9_9BILA Unreviewed; 436 AA.
AC A0A183I1J9;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 08-NOV-2023, entry version 28.
DE RecName: Full=Histone acetyltransferase {ECO:0000256|ARBA:ARBA00013184, ECO:0000256|RuleBase:RU361211};
DE EC=2.3.1.48 {ECO:0000256|ARBA:ARBA00013184, ECO:0000256|RuleBase:RU361211};
GN ORFNames=OFLC_LOCUS13611 {ECO:0000313|EMBL:VDP14204.1}, X798_05665
GN {ECO:0000313|EMBL:OZC07355.1};
OS Onchocerca flexuosa.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Onchocerca.
OX NCBI_TaxID=387005 {ECO:0000313|Proteomes:UP000050787, ECO:0000313|WBParaSite:OFLC_0001361201-mRNA-1};
RN [1] {ECO:0000313|EMBL:OZC07355.1, ECO:0000313|Proteomes:UP000242913}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Red Deer {ECO:0000313|EMBL:OZC07355.1};
RA Mitreva M.;
RT "Draft genome of the nematode, Onchocerca flexuosa.";
RL Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|WBParaSite:OFLC_0001361201-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (JUN-2016) to UniProtKB.
RN [3] {ECO:0000313|EMBL:VDP14204.1, ECO:0000313|Proteomes:UP000267606}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=acetyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-acetyl-L-
CC lysyl-[protein]; Xref=Rhea:RHEA:45948, Rhea:RHEA-COMP:9752,
CC Rhea:RHEA-COMP:10731, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:61930; EC=2.3.1.48;
CC Evidence={ECO:0000256|RuleBase:RU361211};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU361211}.
CC -!- SIMILARITY: Belongs to the MYST (SAS/MOZ) family.
CC {ECO:0000256|ARBA:ARBA00010107, ECO:0000256|RuleBase:RU361211}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KZ270034; OZC07355.1; -; Genomic_DNA.
DR EMBL; UZAJ01040292; VDP14204.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A183I1J9; -.
DR STRING; 387005.A0A183I1J9; -.
DR WBParaSite; OFLC_0001361201-mRNA-1; OFLC_0001361201-mRNA-1; OFLC_0001361201.
DR Proteomes; UP000050787; Unplaced.
DR Proteomes; UP000242913; Unassembled WGS sequence.
DR Proteomes; UP000267606; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0004402; F:histone acetyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR Gene3D; 2.30.30.140; -; 1.
DR Gene3D; 3.40.630.30; -; 1.
DR Gene3D; 3.30.60.60; N-acetyl transferase-like; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR016181; Acyl_CoA_acyltransferase.
DR InterPro; IPR016197; Chromo-like_dom_sf.
DR InterPro; IPR002717; HAT_MYST-type.
DR InterPro; IPR025995; Tudor-knot.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR040706; Zf-MYST.
DR PANTHER; PTHR10615; HISTONE ACETYLTRANSFERASE; 1.
DR PANTHER; PTHR10615:SF82; HISTONE ACETYLTRANSFERASE KAT8; 1.
DR Pfam; PF01853; MOZ_SAS; 1.
DR Pfam; PF11717; Tudor-knot; 1.
DR Pfam; PF17772; zf-MYST; 1.
DR SUPFAM; SSF55729; Acyl-CoA N-acyltransferases (Nat); 1.
DR SUPFAM; SSF54160; Chromo domain-like; 1.
DR PROSITE; PS51726; MYST_HAT; 1.
PE 3: Inferred from homology;
KW Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Nucleus {ECO:0000256|RuleBase:RU361211};
KW Reference proteome {ECO:0000313|Proteomes:UP000242913};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 163..435
FT /note="MYST-type HAT"
FT /evidence="ECO:0000259|PROSITE:PS51726"
FT COILED 138..165
FT /evidence="ECO:0000256|SAM:Coils"
FT ACT_SITE 339
FT /note="Proton donor/acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR602717-51"
SQ SEQUENCE 436 AA; 51504 MW; 4546D8D1BAF38F88 CRC64;
VSADCRIRTT ITSHSRSSVG SALYEREYIT TRQHRYLRRN GIVNEETQSN SNDQLALGEI
CMVLRHGSAR RRRAVIIDKR PAERGTGNEY YVHYEGTDRR LDEWAQRSQI QKVIQRNEAD
DDNRRKITRI RKRKHIEMIE ALNSHSTAED ERMALEKEHE EVTKVKHIER IRYGNYEIDT
WYFSPYPDDY GKAHSLYICQ YCMRYMKFER SYRIHLLECR RKEPPGVEIY KEKSMSVYEV
LGSNDKVYCQ CLCLLAKLFL DHKTLYFDVE PFLFYVLCEV DSRGAQMVGY FSKEQGNPDG
NNLACICILP PFQRSGYGKF LIQLSYEISK REGLIGSPEK PLSDLGKLSY RSYWSWAVLE
VLRTCSKISI TDLSRRTAIH VNDIIETLHS LKLTRYWKGD HVLYVTQRFL IHCWKTGVAK
KPRLLLRPRL LRWQPR
//
