ID A0A183K2V3_9TREM Unreviewed; 1241 AA.
AC A0A183K2V3;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=ANK_REP_REGION domain-containing protein {ECO:0000313|WBParaSite:SCUD_0000931701-mRNA-1};
GN ORFNames=SCUD_LOCUS9317 {ECO:0000313|EMBL:VDP35120.1};
OS Schistosoma curassoni.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX NCBI_TaxID=6186 {ECO:0000313|Proteomes:UP000050789, ECO:0000313|WBParaSite:SCUD_0000931701-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:SCUD_0000931701-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (JUN-2016) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDP35120.1, ECO:0000313|Proteomes:UP000279833}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Dakar {ECO:0000313|EMBL:VDP35120.1}, and Dakar, Senegal
RC {ECO:0000313|Proteomes:UP000279833};
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; UZAK01033169; VDP35120.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A183K2V3; -.
DR STRING; 6186.A0A183K2V3; -.
DR WBParaSite; SCUD_0000931701-mRNA-1; SCUD_0000931701-mRNA-1; SCUD_0000931701.
DR Proteomes; UP000050789; Unplaced.
DR Proteomes; UP000279833; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005216; F:monoatomic ion channel activity; IEA:InterPro.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR005821; Ion_trans_dom.
DR PANTHER; PTHR13800:SF41; PROTEIN CED-11; 1.
DR PANTHER; PTHR13800; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR SMART; SM00248; ANK; 4.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000279833};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 690..709
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 749..767
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 830..848
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 928..952
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 121..157
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 690..963
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 213..242
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1028..1050
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1112..1133
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1218..1241
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1241 AA; 141462 MW; E26EB0DE0B2A56AF CRC64;
MLAQQEYLVE HGTASLQEAD ENGRLPIHVA AVFGQPVILS YLIRVLSTRL HPLNIPAQFL
SALNEDNECS LEEEEAEDNV NMKQNENAFH CKLPEAANNS SDSFKTSIMK TIAAANYLDM
NHWTPLHHAS CEDAVNYYYD CIKILLDNGA DPMLPTSQGK TALDLAYAAG RSQLLVDVLP
KKQLIALLML IDDIVPLKVR KRLSEEEKLK ERTGLGGMTA SEPYSVMSTK REPSPGLSAD
MHKRSRKGYS FIRRLADKMD TTDVSKGQLG NFTKTVKVDS TNIMSIWRKI LLNDNVELLE
TLRDSLAWRQ SKSNTSTLPT DFSKISDSIT MPTDHISLDD FETAQQISLK QMSELFSDCY
ENGTGVFTHV QGAFQENLKA HDFRTVLQSM SGLLTFKSLS TNKIVILRPM HRSLLFLAII
CGRFRVVEQL IRMRQFDVLP AAVLVTLILR RLHKEPTFPQ QMLGELITFA DRLEAIAVDV
LNLVFLKDNT PEKMICRSML NAPLRTFGGI SLIDLCAKAK CTNVLSLSCC QRLLDERWHG
VLICLPIWMR WTCKFFPVAG LFYFEYRTKK ELKRAELIRN ITANAALGGK VTPNLLSDSA
GRTESKSTGN IIAKVFPATP QLPNNPLTIK RTKPLKVQNT ISVHSSQGPK PHVSIYERMS
NQFGWTSSPR FHFVTGVYLS PSMKFCLHSL FHLLFLMLFS VVCVYNLHFS CSRMEVVSLS
YVLGYAFEEL RQLILEASRD GFSDYFRDGW NWIDVFAITL TFIGFCTRMN VVNKHGSEFE
EAHDVILYTT RNLYMLGLNL FYMRTLHITS ISPIIGPRLK MMADMLRKDL IPLLIVFAIF
IVSYGVWFQG LIYPNSFYET HGQRQNKHLM NSTELSRQRD MQRLGVLMSF SELFRRAFYS
IFEVSIVLEE ETCEDNKYCG SELGFNTVIF FVLVLYVGIV NIILINLLIA LFSNTVSRID
QKSTAHWLAG RYKMVKEYSE RTLLPPPFNT LCIIYELFRC FYIGTSQCFC KDIKFPFGRN
KKLFKTESND DLEEQENESP DEENSNLKKH LTRENQLIKI KEENNRRIKL LMGESDDRGK
LYKQEIDAVL KFILIQSFAL QNSRHTLGTG VSFRGPYTSQ NTSSSDGTTN NESIQLRNNQ
IDSRLERIEA ILEKVVDRVN QIKITDTLST QETPTIRSPV PIRMPSVKLT HAPTDVQFTA
TKIPTSKELF QQLSDEFRNE TETNTQSLSS KPPSIKIQKS L
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