ID A0A183KQY2_9TREM Unreviewed; 417 AA.
AC A0A183KQY2;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=SH2 domain-containing protein {ECO:0000313|WBParaSite:SCUD_0001747001-mRNA-1};
GN ORFNames=SCUD_LOCUS17467 {ECO:0000313|EMBL:VDP63630.1};
OS Schistosoma curassoni.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX NCBI_TaxID=6186 {ECO:0000313|Proteomes:UP000050789, ECO:0000313|WBParaSite:SCUD_0001747001-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:SCUD_0001747001-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (JUN-2016) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDP63630.1, ECO:0000313|Proteomes:UP000279833}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Dakar {ECO:0000313|EMBL:VDP63630.1}, and Dakar, Senegal
RC {ECO:0000313|Proteomes:UP000279833};
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; UZAK01039827; VDP63630.1; -; Genomic_DNA.
DR STRING; 6186.A0A183KQY2; -.
DR WBParaSite; SCUD_0001747001-mRNA-1; SCUD_0001747001-mRNA-1; SCUD_0001747001.
DR Proteomes; UP000050789; Unplaced.
DR Proteomes; UP000279833; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 2.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR PANTHER; PTHR24173; ANKYRIN REPEAT CONTAINING; 1.
DR PANTHER; PTHR24173:SF74; UVEAL AUTOANTIGEN WITH COILED-COIL DOMAINS AND ANKYRIN REPEATS; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF00017; SH2; 1.
DR SMART; SM00248; ANK; 3.
DR SMART; SM00252; SH2; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 2.
DR PROSITE; PS50088; ANK_REPEAT; 2.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50001; SH2; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW ATP-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Reference proteome {ECO:0000313|Proteomes:UP000279833};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191}.
FT REPEAT 17..49
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 85..117
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 153..253
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT REGION 314..340
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 316..340
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 411
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 417 AA; 45113 MW; BCBDB627F184FBB8 CRC64;
MEVTSLSDYV NEKSADSGAT PLIEAAKTGS NDIVRLLLEH NASVNLRDCG GFTALHRACQ
KSFAHVAETL LRVGRANPQI KCPFSGNTAL HEAAMLGHAD CVNCLLRYHA APWARNAEAE
MPFELALRYG FADLAAALAG YKPAPAITMQ NDWYHPSLSK SETDKIFSNC STIKDGAFLI
RRSSQSERKF VLVLYYQHQT LKYQIEVVDF SFHMDTKEAY FIDKGPLHLS LEHLVEHYSR
FADGIPVRLH YAISPSGRIT NIEQLVPHNL DNHGQELRKI ESSAVGGDAW ALRTISSSLH
GGRMGAPLSM SIAKGASRHG QKSNQGKHHS SSSSGVSGMS SGGGLLPVAA GLQLTASGTS
CIGSTTGSGE LRLIPSDAVI LLYRLGEGEF GEVYRGRLHL DNGIVQEVAV KVSQCVI
//
