ID   A0A183LIP3_9TREM        Unreviewed;      1019 AA.
AC   A0A183LIP3;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=Ras-GEF domain-containing protein {ECO:0000313|WBParaSite:SMRZ_0000366701-mRNA-1};
GN   ORFNames=SMRZ_LOCUS3668 {ECO:0000313|EMBL:VDO58784.1};
OS   Schistosoma margrebowiei.
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC   Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX   NCBI_TaxID=48269 {ECO:0000313|WBParaSite:SMRZ_0000366701-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:SMRZ_0000366701-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (JUN-2016) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:VDO58784.1, ECO:0000313|Proteomes:UP000277204}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Zambia {ECO:0000313|EMBL:VDO58784.1,
RC   ECO:0000313|Proteomes:UP000277204};
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; UZAI01001079; VDO58784.1; -; Genomic_DNA.
DR   STRING; 48269.A0A183LIP3; -.
DR   WBParaSite; SMRZ_0000366701-mRNA-1; SMRZ_0000366701-mRNA-1; SMRZ_0000366701.
DR   Proteomes; UP000277204; Unassembled WGS sequence.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR   InterPro; IPR008937; Ras-like_GEF.
DR   InterPro; IPR023578; Ras_GEF_dom_sf.
DR   InterPro; IPR001895; RASGEF_cat_dom.
DR   InterPro; IPR036964; RASGEF_cat_dom_sf.
DR   PANTHER; PTHR23113:SF327; EXCHANGE PROTEIN DIRECTLY ACTIVATED BY CAMP, ISOFORM E; 1.
DR   PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR   Pfam; PF00617; RasGEF; 1.
DR   SUPFAM; SSF48366; Ras GEF; 1.
DR   PROSITE; PS50009; RASGEF_CAT; 1.
PE   4: Predicted;
KW   Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW   ECO:0000256|PROSITE-ProRule:PRU00168};
KW   Reference proteome {ECO:0000313|Proteomes:UP000277204}.
FT   DOMAIN          1..104
FT                   /note="Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50009"
FT   REGION          123..147
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          160..212
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          300..326
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          596..622
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          679..713
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          857..942
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        163..212
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1019 AA;  112643 MW;  9646A84342A6F4EC CRC64;
     MVLDTSRNFH HYRTLLSANN VSAPILPYLP LVLKDLTFIH LGNPSCTPDG LINFVKLRML
     AKEVRAICRM CNVDYDLCTT PYRGRTAGGV ERVRAGANLS ALKAVASVSS IYPKSYFSNL
     TSMNNSSQTN HNNNNNNNNN NARTDSNWPE HDMVEVKFSH SNSLDDSEQQ QQRESTLNFD
     ANPMNSTNVS SGLNVGHKRL HQHGNPTTPS SGSFNVELST ANSFIVPGGG IRRRSNLGLI
     SSSINPKKIY ESWLMTLRIR TYFANLRVVQ DPELLSQLSS RIEPSGKDSR TVQPALVSSV
     GNAGTTTNNN NNNNINSSTN EGNDPQKLYT SNLPSSNNNT KLKGIKLSPT KTSAQSVIVE
     SNTNKKSPLK VINVSTESPY VPSATVAAPI TSHPASTDPK NMFTRPLLGA QSVEDARKLL
     SLSVGSKCSS QRRLPVFTFP NHFHYNSTHN VAQSLFITSP VRPYAGIGFG HLKSQHYNNS
     NVSSSLGSSY QVNNNTIIQM SNNSTPKSSS TSNATISTCS NHLHHHHHHY SNTQLIYPQP
     TRCYSTSTDT TGSKSLLLDN LIPIPSRIAT NMNDSGNSNS TSNQMYAMLP NQRDPCHLHQ
     QQHSLTHHQQ ASASPPHNRG QATMKHQYFS QATNQNTNYQ YQAPSNSIAS RLTLNSNTAT
     VLYPSCPGIS LQQQITCPHR STNLPGGGAY PSNQQQQQAT VQSGRFREQS SLQQHQHSVS
     FNFDENYLYP TANTLPLGGS ILSIPRNYRQ SIIQRIIPQY LNCKPTRPPP YEIALALKYP
     QNANSQRVYQ SLKNDTINTR HENNNNSINN NNNNYHIASN LSSGIKHGTV GHVPLAQTYT
     QIQNSKSDKQ LFTVKQLPDK NPQNPINYAS STTTSTTTTS TIVSSRSEFS NNSNNSNNNL
     QYRPSERNKS STVCQSFQQR IQERPSPPSY QQVLSMSRQG NNQGSLKIIS AQSHPRTNIY
     SSHGRPQPPQ RTMVTLSSNC NHNNYRASSC SPGMTIVRPV VNDLNTVEPH RKHIGRLVD
//