ID A0A183LK03_9TREM Unreviewed; 555 AA.
AC A0A183LK03;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Guanylate cyclase domain-containing protein {ECO:0000313|WBParaSite:SMRZ_0000412701-mRNA-1};
GN ORFNames=SMRZ_LOCUS4128 {ECO:0000313|EMBL:VDO60189.1};
OS Schistosoma margrebowiei.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX NCBI_TaxID=48269 {ECO:0000313|WBParaSite:SMRZ_0000412701-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:SMRZ_0000412701-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (JUN-2016) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDO60189.1, ECO:0000313|Proteomes:UP000277204}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Zambia {ECO:0000313|EMBL:VDO60189.1,
RC ECO:0000313|Proteomes:UP000277204};
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; UZAI01001275; VDO60189.1; -; Genomic_DNA.
DR STRING; 48269.A0A183LK03; -.
DR WBParaSite; SMRZ_0000412701-mRNA-1; SMRZ_0000412701-mRNA-1; SMRZ_0000412701.
DR Proteomes; UP000277204; Unassembled WGS sequence.
DR GO; GO:0004383; F:guanylate cyclase activity; IEA:UniProtKB-EC.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07302; CHD; 1.
DR Gene3D; 6.10.250.780; -; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR011645; HNOB_dom_associated.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR PANTHER; PTHR45655; GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-2; 1.
DR PANTHER; PTHR45655:SF10; SOLUBLE GUANYLATE CYCLASE 88E; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR Pfam; PF07701; HNOBA; 1.
DR SMART; SM00044; CYCc; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE 4: Predicted;
KW Lyase {ECO:0000256|ARBA:ARBA00023239};
KW Reference proteome {ECO:0000313|Proteomes:UP000277204}.
FT DOMAIN 101..245
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
FT REGION 320..459
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 484..555
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 329..349
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 350..375
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 388..428
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 431..455
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 501..535
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 555 AA; 62225 MW; EFAD9B36542F0F7E CRC64;
MDLIRDTKQL YEKKLRISDL NTFDSSRDII IQGNQQSDEV MKLYEKQRHK AKQMEKSMMQ
LEKIRKVTDE LLYQCIPSTV ARKIRNGTPA IDTIQTFDEV TICFTKVVNF AAKCMHIGVE
QVIELLNRMY SFYDALTENH KVYKVETVND SYMLVSGAPH RTPLHAAHIV DTALEIIEVT
LLSLYWPEST ENIPANNKNK TVYTDENLHL YIGCHTGPIV AGVVGYKTPR YCLFGDTVNT
SSRMMSHGSP DKVHISESCA QSLSPYPYET ECRGEIPIKG KGNMKTYFVT GRKPEFVFQD
TTDGGSRNFA EVLKEDMLKD DDIPSENSDD SAKFSINLSD ASGTTEEESP PASPKDDREL
EVNEKISEKK DRKSSKGGSR RSSKSGQKRR QSQPLSNTTS PTNENPDAEN QQSSSGFVNN
QNTTEVLNEA ARRLVETKIK DVKNEQKKKQ DITFSLDNPK EILKEAPSEA DLQAVDNNVD
EATLFKSKPK APERSRLIKL NPANKVSSVS VSSKPIQPTP DKVAVNNVSS DVTESAQNDD
NDEVTQETGN QEDSK
//
