ID A0A183MUU6_9TREM Unreviewed; 608 AA.
AC A0A183MUU6;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Calpain catalytic domain-containing protein {ECO:0000313|WBParaSite:SMRZ_0001982201-mRNA-1};
GN ORFNames=SMRZ_LOCUS19821 {ECO:0000313|EMBL:VDP33069.1};
OS Schistosoma margrebowiei.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX NCBI_TaxID=48269 {ECO:0000313|WBParaSite:SMRZ_0001982201-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:SMRZ_0001982201-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (JUN-2016) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDP33069.1, ECO:0000313|Proteomes:UP000277204}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Zambia {ECO:0000313|EMBL:VDP33069.1,
RC ECO:0000313|Proteomes:UP000277204};
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase C2 family.
CC {ECO:0000256|ARBA:ARBA00007623}.
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DR EMBL; UZAI01018089; VDP33069.1; -; Genomic_DNA.
DR STRING; 48269.A0A183MUU6; -.
DR WBParaSite; SMRZ_0001982201-mRNA-1; SMRZ_0001982201-mRNA-1; SMRZ_0001982201.
DR Proteomes; UP000277204; Unassembled WGS sequence.
DR GO; GO:0004198; F:calcium-dependent cysteine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00044; CysPc; 1.
DR Gene3D; 2.60.120.380; -; 2.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR022684; Calpain_cysteine_protease.
DR InterPro; IPR022682; Calpain_domain_III.
DR InterPro; IPR036213; Calpain_III_sf.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR001300; Peptidase_C2_calpain_cat.
DR PANTHER; PTHR46143; CALPAIN-7; 1.
DR PANTHER; PTHR46143:SF1; CALPAIN-7; 1.
DR Pfam; PF01067; Calpain_III; 1.
DR Pfam; PF00648; Peptidase_C2; 1.
DR PRINTS; PR00704; CALPAIN.
DR SMART; SM00230; CysPc; 1.
DR SUPFAM; SSF49758; Calpain large subunit, middle domain (domain III); 2.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR PROSITE; PS50203; CALPAIN_CAT; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00239}; Protease {ECO:0000256|PROSITE-ProRule:PRU00239};
KW Reference proteome {ECO:0000313|Proteomes:UP000277204};
KW Thiol protease {ECO:0000256|PROSITE-ProRule:PRU00239}.
FT DOMAIN 132..411
FT /note="Calpain catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50203"
FT REGION 33..64
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 33..52
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 161
FT /evidence="ECO:0000256|PIRSR:PIRSR622684-1,
FT ECO:0000256|PROSITE-ProRule:PRU00239"
FT ACT_SITE 329
FT /evidence="ECO:0000256|PIRSR:PIRSR622684-1,
FT ECO:0000256|PROSITE-ProRule:PRU00239"
FT ACT_SITE 349
FT /evidence="ECO:0000256|PIRSR:PIRSR622684-1,
FT ECO:0000256|PROSITE-ProRule:PRU00239"
SQ SEQUENCE 608 AA; 69327 MW; 40D2F08A3FC8BD2C CRC64;
MANPHELEKD ADWFKRLAVA EGLKAYVQRT KPPCSDSRSS CSTLTSQMTG TSKKSHDFHK
PNMSSSLKGD PGGFTVEELE VLRSTSVING REYLPFLDAL DLQERFSFAN PFVDKDGLLA
LSNKQKSLLS RWVRPSDYIN GPKMILAISC FSICQTVVTD CSFVASMAIA AQYERRFKKK
LITNVIYPQG ITNEAIYNPC GKYMVRLNFN GVPRKVIIDD FLPMGKDGKL LCCYSNNQNE
LWVSLLEKAY MKVMGGYDFP GSNSNIDLHA LTGWIPERIS IRSSSTSFDK DKEFRRLLSR
FHKGHCLVTI ATGQLSDDES ERSGLVPTHA YAMLDIREVE GYRLFLLKNP WSHMRWKGNF
SERDSKHWTP SMQAKLNFDR SSAQLIDNGV FWIDYDSLCH FFDVFYINWD PGLFQYTTCV
NDCWLAGSGP KKDSYASAEN PQYNLEVTAQ TESPIWVLLT RHIVDKADFA ENKEFIAVVV
YKDVKSRKVY YPYDPAPFCD SVRINSPHCL VKMLQDPGTC NYILLISQYE KSITIYYTLR
VYSTAPFTLS KIKDPYTISK QITGEWKGSN AGGCINDKES YRTNPRFEIN VPNNNCDNQL
LIELRGPR
//
