ID A0A183N570_9TREM Unreviewed; 517 AA.
AC A0A183N570;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Integrin_alpha2 domain-containing protein {ECO:0000313|WBParaSite:SMRZ_0002344601-mRNA-1};
GN ORFNames=SMRZ_LOCUS23445 {ECO:0000313|EMBL:VDP47250.1};
OS Schistosoma margrebowiei.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX NCBI_TaxID=48269 {ECO:0000313|WBParaSite:SMRZ_0002344601-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:SMRZ_0002344601-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (JUN-2016) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDP47250.1, ECO:0000313|Proteomes:UP000277204}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Zambia {ECO:0000313|EMBL:VDP47250.1,
RC ECO:0000313|Proteomes:UP000277204};
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
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DR EMBL; UZAI01019712; VDP47250.1; -; Genomic_DNA.
DR STRING; 48269.A0A183N570; -.
DR WBParaSite; SMRZ_0002344601-mRNA-1; SMRZ_0002344601-mRNA-1; SMRZ_0002344601.
DR Proteomes; UP000277204; Unassembled WGS sequence.
DR GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR000413; Integrin_alpha.
DR InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR032695; Integrin_dom_sf.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF133; INTEGRIN ALPHA-PS2; 1.
DR Pfam; PF01839; FG-GAP; 1.
DR Pfam; PF20805; Integrin_A_Ig_2; 1.
DR PRINTS; PR01185; INTEGRINA.
DR SMART; SM00191; Int_alpha; 3.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 1.
DR PROSITE; PS51470; FG_GAP; 2.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003762};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW Reference proteome {ECO:0000313|Proteomes:UP000277204};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT REPEAT 1..58
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 102..165
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT DOMAIN 422..488
FT /note="Integrin alpha second immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20805"
SQ SEQUENCE 517 AA; 58587 MW; 4684E56F492F9793 CRC64;
MSNFNRSMIL SNHICLAVAD LDGNGLVDII VGAPYFTRRQ NQEGSQDTIN SKQFNHNEGI
QWSNLLPDIG RVYIFYGNHL NLSNLLSDSK QRPEIPDYFT QDPVILDGPK SPKGRFGHAL
TNIGDIDGDG TEDLAVSCPY CTDPDGRTDK GAVFIYLGKK DSILDTKPFQ SIWPSDLPKQ
SPVTICGSTD FTSDYASESP RLFTAFGWSL SGSYDLDGNH APDLVIGDYE SDQVVMLRGR
NTLWFDSPIW ELPTQPTLSW RYKDTLTCDE QCYFPIQLSA RINGKQHLLK QIKDWKLRLL
IDLDSDVEQP ENKRLAIQTT RKQMIYQSTD KGIIDMLVEL KTDEFIEENS SRITLFDFIV
KPLTSRISAL LWKPVRINVT LNPVHEPMSF VEHKSISSWI LHPFLGSRNF ISRSMQFANP
ACGVDNICRP DLQVQMIDIS EGPTDKSIIY FRERVSQRNI TVHIGNLGEN AYSTQLHMIF
PDQLSFSMPE GLSCQTVTLN DLKVSLYFAQ ICSLQQF
//
