ID   A0A183QFP9_9TREM        Unreviewed;       554 AA.
AC   A0A183QFP9;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   SubName: Full=Calpain catalytic domain-containing protein {ECO:0000313|WBParaSite:SROB_0000245901-mRNA-1};
OS   Schistosoma rodhaini.
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC   Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX   NCBI_TaxID=6188 {ECO:0000313|WBParaSite:SROB_0000245901-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:SROB_0000245901-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (JUN-2016) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the peptidase C2 family.
CC       {ECO:0000256|ARBA:ARBA00007623}.
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DR   AlphaFoldDB; A0A183QFP9; -.
DR   STRING; 6188.A0A183QFP9; -.
DR   WBParaSite; SROB_0000245901-mRNA-1; SROB_0000245901-mRNA-1; SROB_0000245901.
DR   GO; GO:0004198; F:calcium-dependent cysteine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd00214; Calpain_III; 1.
DR   CDD; cd00044; CysPc; 1.
DR   Gene3D; 2.60.120.380; -; 1.
DR   Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR   InterPro; IPR033883; C2_III.
DR   InterPro; IPR022684; Calpain_cysteine_protease.
DR   InterPro; IPR022682; Calpain_domain_III.
DR   InterPro; IPR022683; Calpain_III.
DR   InterPro; IPR036213; Calpain_III_sf.
DR   InterPro; IPR038765; Papain-like_cys_pep_sf.
DR   InterPro; IPR000169; Pept_cys_AS.
DR   InterPro; IPR001300; Peptidase_C2_calpain_cat.
DR   PANTHER; PTHR10183; CALPAIN; 1.
DR   PANTHER; PTHR10183:SF379; CALPAIN-A-RELATED; 1.
DR   Pfam; PF01067; Calpain_III; 1.
DR   Pfam; PF00648; Peptidase_C2; 1.
DR   PRINTS; PR00704; CALPAIN.
DR   SMART; SM00720; calpain_III; 1.
DR   SMART; SM00230; CysPc; 1.
DR   SUPFAM; SSF49758; Calpain large subunit, middle domain (domain III); 1.
DR   SUPFAM; SSF54001; Cysteine proteinases; 1.
DR   PROSITE; PS50203; CALPAIN_CAT; 1.
DR   PROSITE; PS00139; THIOL_PROTEASE_CYS; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW   ProRule:PRU00239};
KW   Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW   ProRule:PRU00239};
KW   Thiol protease {ECO:0000256|ARBA:ARBA00022807, ECO:0000256|PROSITE-
KW   ProRule:PRU00239}.
FT   DOMAIN          1..270
FT                   /note="Calpain catalytic"
FT                   /evidence="ECO:0000259|PROSITE:PS50203"
FT   ACT_SITE        27
FT                   /evidence="ECO:0000256|PIRSR:PIRSR622684-1,
FT                   ECO:0000256|PROSITE-ProRule:PRU00239"
FT   ACT_SITE        186
FT                   /evidence="ECO:0000256|PIRSR:PIRSR622684-1,
FT                   ECO:0000256|PROSITE-ProRule:PRU00239"
FT   ACT_SITE        210
FT                   /evidence="ECO:0000256|PIRSR:PIRSR622684-1,
FT                   ECO:0000256|PROSITE-ProRule:PRU00239"
SQ   SEQUENCE   554 AA;  63118 MW;  EDCF6FCA59380A0F CRC64;
     MDINPLAAFC TKSYSRFDVD QGALGDCWFA SVMATVTKYP ALMSNIIPPN QTFKGSGYTG
     AFVFNFWRFG EWVEVVVDDR IPVVKGTCNP VFIHSTDNSE FWSCLLEKAY AKLCGSYAHL
     TGGFQSEAME DFTGGICTTL ILNKKERPPN LLKMMEHYTK TCCVMGADVG GDKNKRREEL
     GLIGSHAYSV TGVGKVNYMG KDVHLVRCRN PWGERHEWKG PWSDNSPEWK DVKSKDKKAL
     QYKPKEDGEF WMSFQDFEDY FSLLEICHFG YSSLDCKDEI DKKKRCEEIC FLGEWVANVN
     AGGSRDYPES FCTNPQYLFT IGTDNSGKVG KAHIIVGVMQ EHRRFLYGAD YLAIGFSIYE
     VSELQNTCLT PEELLCRKPL LTSDYIPRRE VTLEADLFPG TFILIPSTYN SNQEARYICR
     VFSTVKMKQL ELDEENSYEG FPKKELASLE LNFKQLCNPV TEKINSRILG TILDQSNFGE
     YMDGFTEFPS NLCSSLISSA SVSFIKINHN TGHDLIRLTV NKFRNHNTKL SVFENDYLKM
     RWKSVTVYID GNKE
//