ID   A0A183VN18_TRIRE        Unreviewed;       319 AA.
AC   A0A183VN18;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=Iso_dh domain-containing protein {ECO:0000313|WBParaSite:TRE_0000187601-mRNA-1};
GN   ORFNames=TRE_LOCUS1874 {ECO:0000313|EMBL:VDP97753.1};
OS   Trichobilharzia regenti (Nasal bird schistosome).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC   Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Trichobilharzia.
OX   NCBI_TaxID=157069 {ECO:0000313|WBParaSite:TRE_0000187601-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:TRE_0000187601-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (JUN-2016) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:VDP97753.1, ECO:0000313|Proteomes:UP000280995}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|ARBA:ARBA00001946};
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|ARBA:ARBA00001936};
CC   -!- SIMILARITY: Belongs to the isocitrate and isopropylmalate
CC       dehydrogenases family. {ECO:0000256|ARBA:ARBA00007769}.
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DR   EMBL; UZAO01048271; VDP97753.1; -; Genomic_DNA.
DR   STRING; 157069.A0A183VN18; -.
DR   WBParaSite; TRE_0000187601-mRNA-1; TRE_0000187601-mRNA-1; TRE_0000187601.
DR   Proteomes; UP000280995; Unassembled WGS sequence.
DR   GO; GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.
DR   GO; GO:0006102; P:isocitrate metabolic process; IEA:InterPro.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.718.10; Isopropylmalate Dehydrogenase; 1.
DR   InterPro; IPR004790; Isocitrate_DH_NADP.
DR   InterPro; IPR024084; IsoPropMal-DH-like_dom.
DR   NCBIfam; TIGR00127; nadp_idh_euk; 1.
DR   PANTHER; PTHR11822:SF21; ISOCITRATE DEHYDROGENASE [NADP], MITOCHONDRIAL; 1.
DR   PANTHER; PTHR11822; NADP-SPECIFIC ISOCITRATE DEHYDROGENASE; 1.
DR   Pfam; PF00180; Iso_dh; 1.
DR   SMART; SM01329; Iso_dh; 1.
DR   SUPFAM; SSF53659; Isocitrate/Isopropylmalate dehydrogenase-like; 1.
PE   3: Inferred from homology;
KW   Glyoxylate bypass {ECO:0000256|ARBA:ARBA00022435};
KW   Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW   Manganese {ECO:0000256|ARBA:ARBA00023211};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000280995};
KW   Tricarboxylic acid cycle {ECO:0000256|ARBA:ARBA00022532}.
FT   DOMAIN          8..319
FT                   /note="Isopropylmalate dehydrogenase-like"
FT                   /evidence="ECO:0000259|SMART:SM01329"
SQ   SEQUENCE   319 AA;  36119 MW;  DA15277C70A82794 CRC64;
     MRVKVANPVV DLDGDEMTRI IWEKIKSTLI LPFVDVECKY YDLGLTNRDQ TNDQVTIDAA
     HAIKKYNVGI KCATITPDEQ RVKEFNLKKM WLSPNGTIRN ILGGTVFREP ILCKNVPRLV
     PGWTKPIVIG RHAHGDQYKA SDVVIKEPGL MELVFTPKSK GSVERIKVFE FNGGGVGLAM
     YNTDESIRGF ARSCFEYALS KKWPLYLSTK NTILKRYDGR FKDIFQEIYE QDYQKEYEAA
     NIWYEHRLID DMVAQALKSD GGFVWACKNY DGDVQSDVVA QGKLNFGTPL LTLAGSRAKY
     HELSLVKISG PLDSFSVAE
//