ID   A0A183VT31_TRIRE        Unreviewed;       519 AA.
AC   A0A183VT31;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   27-MAR-2024, entry version 31.
DE   RecName: Full=Ras-GEF domain-containing protein {ECO:0008006|Google:ProtNLM};
OS   Trichobilharzia regenti (Nasal bird schistosome).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC   Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Trichobilharzia.
OX   NCBI_TaxID=157069 {ECO:0000313|WBParaSite:TRE_0000364001-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:TRE_0000364001-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (JUN-2016) to UniProtKB.
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DR   AlphaFoldDB; A0A183VT31; -.
DR   STRING; 157069.A0A183VT31; -.
DR   WBParaSite; TRE_0000364001-mRNA-1; TRE_0000364001-mRNA-1; TRE_0000364001.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   CDD; cd06224; REM; 1.
DR   Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR   Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR   InterPro; IPR008937; Ras-like_GEF.
DR   InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR   InterPro; IPR023578; Ras_GEF_dom_sf.
DR   InterPro; IPR001895; RASGEF_cat_dom.
DR   InterPro; IPR036964; RASGEF_cat_dom_sf.
DR   PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR   PANTHER; PTHR23113:SF99; RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 1; 1.
DR   Pfam; PF00617; RasGEF; 1.
DR   Pfam; PF00618; RasGEF_N; 1.
DR   SMART; SM00147; RasGEF; 1.
DR   SMART; SM00229; RasGEFN; 1.
DR   SUPFAM; SSF48366; Ras GEF; 1.
DR   PROSITE; PS50009; RASGEF_CAT; 1.
DR   PROSITE; PS50212; RASGEF_NTER; 1.
PE   4: Predicted;
KW   Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW   ECO:0000256|PROSITE-ProRule:PRU00168}.
FT   DOMAIN          74..206
FT                   /note="N-terminal Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50212"
FT   DOMAIN          320..519
FT                   /note="Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50009"
SQ   SEQUENCE   519 AA;  59576 MW;  88D88A2152FF35C7 CRC64;
     LFKLFYSIVS QEPDDEDDIS PQQLEKEIYL PPPVIETTHR VPILSLVEAN EYLVWGDRNL
     VSNTSAYFLV LSVNDISVHA GCADALTVYM TSYGRMLPSY YLFFETFLFM YRSFMTSEEL
     VDRLITRYQY FSKPPSHFPH LLNLSPDIRS KVCNSTVSIL VTVVSRLKGE LNDALLKILE
     NFVKTLSQDG YDSLSRILQI TVRRQTQEKY QLHSSANSNN VNNSVLRSNS PATHIRVPSL
     GDITPLESNH NYLEYDKDAG FITFPKTKPR HSQPLESFAR YSLVESTGND HSNSVVAPAL
     TYKRLLQNSL KNGQGILNFS AKALAEQFTY LECVNYYKIE VTELLDITKL ERGKAPGVAA
     CARHFTAVSN WATYQILCLS NTSDRDKVAN RLMDVMEHLY KLQNFSTYLS LLCAFLLIPD
     VLFSKKTRSR LSRITPYMQP PYFSKYRHDL EAANPPFIPY LGLMLQNLVV LAQEKMDPEK
     SRYSFRPDED ILRFFSNFEN SLPEAELRRL ANRLRRSVT
//