ID A0A194PKE1_PAPXU Unreviewed; 1362 AA.
AC A0A194PKE1;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=adenylate cyclase {ECO:0000256|ARBA:ARBA00012201};
DE EC=4.6.1.1 {ECO:0000256|ARBA:ARBA00012201};
GN ORFNames=RR46_15064 {ECO:0000313|EMBL:KPI91560.1};
OS Papilio xuthus (Asian swallowtail butterfly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Papilionoidea;
OC Papilionidae; Papilioninae; Papilio.
OX NCBI_TaxID=66420 {ECO:0000313|EMBL:KPI91560.1, ECO:0000313|Proteomes:UP000053268};
RN [1] {ECO:0000313|EMBL:KPI91560.1, ECO:0000313|Proteomes:UP000053268}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ya'a_city_454_Px {ECO:0000313|EMBL:KPI91560.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:KPI91560.1};
RX PubMed=26354079; DOI=10.1038/ncomms9212;
RA Li X., Fan D., Zhang W., Liu G., Zhang L., Zhao L., Fang X., Chen L.,
RA Dong Y., Chen Y., Ding Y., Zhao R., Feng M., Zhu Y., Feng Y., Jiang X.,
RA Zhu D., Xiang H., Feng X., Li S., Wang J., Zhang G., Kronforst M.R.,
RA Wang W.;
RT "Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.";
RL Nat. Commun. 6:8212-8212(2015).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP = 3',5'-cyclic AMP + diphosphate; Xref=Rhea:RHEA:15389,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:58165; EC=4.6.1.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001593};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the adenylyl cyclase class-4/guanylyl cyclase
CC family. {ECO:0000256|RuleBase:RU000405}.
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DR EMBL; KQ459606; KPI91560.1; -; Genomic_DNA.
DR STRING; 66420.A0A194PKE1; -.
DR Proteomes; UP000053268; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0004016; F:adenylate cyclase activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006171; P:cAMP biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07302; CHD; 2.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 2.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR018297; A/G_cyclase_CS.
DR InterPro; IPR009398; Adcy_conserved_dom.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR PANTHER; PTHR45627; ADENYLATE CYCLASE TYPE 1; 1.
DR PANTHER; PTHR45627:SF26; ADENYLATE CYCLASE TYPE 1; 1.
DR Pfam; PF06327; Adcy_cons_dom; 1.
DR Pfam; PF00211; Guanylate_cyc; 2.
DR SMART; SM00044; CYCc; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 2.
DR PROSITE; PS00452; GUANYLATE_CYCLASE_1; 2.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 2.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW cAMP biosynthesis {ECO:0000256|ARBA:ARBA00022998};
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU000405};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022840};
KW Reference proteome {ECO:0000313|Proteomes:UP000053268};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 294..317
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 323..346
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 358..376
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 424..445
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 452..468
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 488..506
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..36
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
FT DOMAIN 573..715
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
FT REGION 187..207
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 761..960
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1023..1075
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1146..1173
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1186..1266
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 761..783
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 820..836
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 850..880
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 913..942
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1041..1058
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1198..1221
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1222..1242
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1362 AA; 149418 MW; 01F5D45BCABA42C3 CRC64;
MRVGIHTGRV LCGVLGLRKW QYDVWSNDVT LANNMEAGGE PGRVHVTQAT LECLGGAYEV
EPGHGGTRNA YLRDHSVQTY FIIPPPRRRK MCLSAGVGLG SGSRRKLSFK NVSNVVVQLL
HSIKFNVDVP FSNMAASPQE LKANAARKEE GTGLGLCQVL DLRRALHAEP GSAEALRLAA
LRGDDVSAPA APAAPAPAAP PPAAAPHHHT FDAVMQHHAL RTHPTNKVTE KFKRPLKKRH
SSVYHQPTNR VNKYLAQAID ARSVHREKAT HVHLLTLCFK DAEKEAQYRA STDGGWAGSL
GAALCALAAG GVLQAAILPR TTILLLLFVT AFAWSAAVLA LTLAARLRLI PCDVSRPFAL
RNAITTFTIV LGYAVGQVNV VTCREIDVCR NLTENVTTMS EIRELRGGLA AALWSAGDHR
ACPVPLYIAL GCCLAVLTVA VFLRLPILIK GILLAVITAG YVSVILAYHK DLFDCYDMMT
DVGVVGSAWS MCLWSLLLAV GVLLHARQTE WTARLDFLWQ AQARDEKRDM DALQASNKRI
LFNLLPAHVA THFLDNQFRT NMDLYHQSYQ RVGVVFASIT NYHEFYMELD GNNQGMECLR
LLNEIIADFD ELLGEDRFSP IDKIKTVGST YMAAVGLIPD KKMTDDPSTR KHMATLVEFV
FAMRDKLKDI NDNSYNNFML RVGINVGPVV AGVIGARKPQ YDIWGNTVNV ASRMDSTGLP
NHTQVTEEVY QVLKDMPYQF VCRGKVKVKG KGEMTTYFLT DRTLDNGGGQ NNSNGQPQNP
PSAYGGVATP LAMLQNSARR AAAQPSRLPP LRESTGSGEN EPLLPPNGQQ NGNNHKGTKG
RRNKDQDDNP PPPPPHGISA NPRWPPPRAL VPPWPRPQEP RPPVVHKRRP PTRLPRPRSS
ESLPLARSPR VHSSADELSS LTRSPSLSSS DESYSRTTDA SPSPPRPAAW LPPARPSRND
ITSAYDYPVL RTNKPTANVI NELYAKHKLS NKPVLEDKIL DDIGYQKEEE KLHRSILNML
QTSAKRDSCS QTDKKDVSSR LAPRTNSFSS SGSRPTNLKH LNHDSREVFS KRSPSDVACV
PPFEREIQRL LDDKNIIMNN PPKNERKDLN LELRSQNSSL EVGRSANNNS SPLHAVGLAA
IAQLARREPS PAPTHPPPPA PTHAHAHAHT DFPGVLPTDV VVCLPSRDNT PGGTFDRKID
SSTKEKHEND AHERLHNRVT TSNHREMNLY GESQSEWSSS CSDGEGDGEG EGECGQPEST
GYTTDDPALE NVSMLNEAGL TDAEAALSDV NSCYFDRDDD VSSRASSRLL DSEALVSLES
LSAIYDSDEP AHRYLANIRT VSESITRNFG QPAHVTDGES DV
//
