ID A0A194Q0A3_PAPXU Unreviewed; 3283 AA.
AC A0A194Q0A3;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Dynein heavy chain, cytoplasmic {ECO:0000313|EMBL:KPI98424.1};
GN ORFNames=RR46_09640 {ECO:0000313|EMBL:KPI98424.1};
OS Papilio xuthus (Asian swallowtail butterfly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Papilionoidea;
OC Papilionidae; Papilioninae; Papilio.
OX NCBI_TaxID=66420 {ECO:0000313|EMBL:KPI98424.1, ECO:0000313|Proteomes:UP000053268};
RN [1] {ECO:0000313|EMBL:KPI98424.1, ECO:0000313|Proteomes:UP000053268}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ya'a_city_454_Px {ECO:0000313|EMBL:KPI98424.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:KPI98424.1};
RX PubMed=26354079; DOI=10.1038/ncomms9212;
RA Li X., Fan D., Zhang W., Liu G., Zhang L., Zhao L., Fang X., Chen L.,
RA Dong Y., Chen Y., Ding Y., Zhao R., Feng M., Zhu Y., Feng Y., Jiang X.,
RA Zhu D., Xiang H., Feng X., Li S., Wang J., Zhang G., Kronforst M.R.,
RA Wang W.;
RT "Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.";
RL Nat. Commun. 6:8212-8212(2015).
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
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DR EMBL; KQ459585; KPI98424.1; -; Genomic_DNA.
DR STRING; 66420.A0A194Q0A3; -.
DR Proteomes; UP000053268; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR CDD; cd00009; AAA; 2.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 1.20.920.60; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 2.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR013594; Dynein_heavy_tail.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR46532:SF4; DYNEIN HEAVY CHAIN 8, AXONEMAL-LIKE PROTEIN; 1.
DR PANTHER; PTHR46532; MALE FERTILITY FACTOR KL5; 1.
DR Pfam; PF12774; AAA_6; 2.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF08385; DHC_N1; 1.
DR Pfam; PF08393; DHC_N2; 2.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 4.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000053268}.
FT DOMAIN 1778..1932
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2095..2308
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2473..2623
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2815..2981
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT COILED 537..564
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1272..1299
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3063..3163
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 3283 AA; 375204 MW; 8A6772D8EF85383F CRC64;
MGDSLDGSES ASEAQNVVAV EFQDFANYLR RAATVLLPED DIVPPALNAA LDDKVNQDCI
RKFISDPQVS SLYVQRFSLK EDDSEQPTEG EEEKEAVNYQ ISNEVHFTSP RVAAFVCIKR
GAVIEADKSI HSQMRLINLS DGSPYETLHA FISKTMAPFF KSYVKESGRA DRDGDKMAPS
VEKKIAELEM GLLHLQQNID IPEITLPVHP LVATVIKRAA DEGRKPRVAD FGDKVEDSTF
LNQLQNGVNR WIKEIQKVTK LDRDPSNGTA LQEISFWLNL ERALHRIQEK RESIEVALTL
DILKYGKRFH ATVSFDTDTG LKQALATVSD YNPLMKDFPI NDLLSATELE RIRLAVQQIF
SHLRKIRSTK YPIQRGLRLV EAISRDLGQQ LLKVLGTRRL MHIPFEDFER VMTQCFEVFS
CWDDEFEKLQ GLLRDIVKKK RDEHIKMVWR VSPSHKRLQA RMEHMRRFRR HHEQLRTVML
RVLRPRVTVN AEQAGGEVTQ PLSLPMDAAD ANAIAEVNLA YENVKEVDCL DISREGCDAW
EAAVRRYEDR IDRVETRITA HLRDQLGTAK NANEMFRIFS RFNALFVRPH IRGAIREYQT
QLIQRVKDDI ETFHEKFKVQ YPQSKCSRLS LVRDLPPVAG SIIWAKQIDH QLTAYLKRVE
DVLGKGWENH IEGQKLKADG DSFRLKLDTQ EVFDDWARKV QQRNLGVSGR IFAIESVRAR
SSKTGTILKL KVNFLPEIIT LYKEVRNLKN LGFRVPLAIV NKAHQANQLY PYAISLIESV
RTYERTLEKI RDKASIIPLV AGLRRDVLNQ VSEGMALVWE SFKLDPYVQK LSEVVLLFQE
KVEDLLAVEE QISVDTRSLE TCPYSAQSLA DILSRLQRAI DDLSLRQYSN LHLWVQRLDE
EVEKKLAARL QAGIEAWTMA LLGKANELDL SMDTYSPAEP THKPGGEPQI ARVVHEVRIT
NQQMYLFPSL EEARFQLMRQ MFAWQAIVTS LHRLQSTRYQ VGVARTQTVT YRNLLTKLPG
GSSPLENAYD AIEQKISQVR EYVDEWLRYQ ALWDLQPETL YGRLGEDITL WIKCLNDIKK
SRTTFDTSDT RREYGPVVID FARVQSKVAL KYDAWHKEVL GKFGALLGGE MVQFHARLAK
SRGQLEQQTI EAASTSDAVS LITYVQQLKR EVLAWEKQVD TYKEAQRILE RQRFQFPTQW
LHVDNIEGEW SAFNEIMRRK DSSIQTQVAS LQQKIVAEDK AVETRTMEFL GEWERNKPTD
GSTRPEDALA RLQVMETRYT KLKDERDNVA KAKEALELHD TGSSVNNERM TVVMEELQDL
RGVWSSLSKI WTQIDDIREK PWLSIQPRKL RQQLEAMLNE LKELPARLRM YDSYEYVRKL
LQSYTKVNML IVELKSDALK ERHWRQLCRA LRVEWALSEL TLGQVWDADL LHNEHTVKDV
VSVAQGEMAL EEFLKQVRES WQSYELDLIN YQNKCKIIRG WDDLFNKVKE HINSVAAMKL
SPYYKFLGLM KKVSKSPMVM DVLNIPGVQR SLERLADLLG KIQKALGEYL ERERSSFPRF
YFVGDEDLLE IIGNSKNIAR LQKHFKKMFA GVAAIILNED NTVINGIASR EGEEVYFTSP
VSTIENPKIN SWLSLVEREM RVTLACRLKD AVSDIKQFKD GNVDPQKFIE WCDKYQAQIV
VLAAQILWSE DVENALSNGG GDGLKQVLTH VEDMLNILAD SVLQEQPPLR RRKLEHLINE
FVHKRTVTRR LIASDVTSAR SFEWLCEMRF YFDHRNNDNK FVCVLGPAGT GKTESVKALG
NQLGRFVLVF NCDETFDFQA MGRIFVGLCQ VGAWGCFDEF NRLEERMLSA VSQQVQTIQE
ALKSHQEGDN TAKSITVELV GKQVRVSQDM AIFITMNPGY AGRSNLPDNL KKLFRSLAMT
TPDRQLIAEV MLFSQGFRTA EKLACKIVPF FKLCDEQLSN QSHYDFGLRA LKSVLVSAGN
VKRDRIQKIK ENLIERGTEV PDEASIAESL PEQDILIQSV CETMVPKLVA EDIPLLFSLL
NDVFPNVGYT RAEMTGLKNE IRAVCAEEFL VCGEGDEQGS TWMDKVLQLY QICKLNHGLM
MVGPSGSGKS TAWRVLLKAL ERFEGVEGVA HVIDPKAMSK ETLYGVLDPN TREWTDGLFT
HILRKIIDNV RGEINKRQWI IFDGDVDPEW VENLNSVLDD NKLLTLPNGE RLSLPPNVRV
MFEVQDLKYA TLATVSRCGM VWFSQDVLTT EMIFENYLLR LRNIPLEDGE EDSFSIVMAA
PTAGGDQNAT ENILSPGLQT QRDVAAILQP LFYGDGLVVK CLERAVSLDH IMDFTRHRAL
SSLHSMLNRG VRNILAYNRQ HPDFPVTNDQ LEAYVPKWLV YSLLWSFAGD AKLKDRNELG
DFIRSASTMV LPNCGANQHI IDFEVSITGE WVPWSAKVPQ IEVETHKVAA PDVVVPTLDT
VRHEALLYTW LAEHKPLVLC GPPGSGKTMT LFSALRALPD MEVVGLNFSS ATTPELLLKT
FDHYCEYRKT PNGVVFAPVQ LGKWLVLFCD EINLPDMDQY GTQRVISFLR QLLEHKGFYR
ASDHSWVHLE RIQFVGACNP PTDPGRKPLS HRLLRHVPVI YVDYPGETSL EQIYGTFTRA
MLRMQPSLRG YAEPLTQAMV HLYLASQERF TQDMQPHYVY SPREMTRWVR GICEAIRPLD
NLSVEGLVRL WAHEALRLFQ DRLVEDSERQ WTDENIDTVA MRFFPGINRE QALARPILYS
NWLSKDYVPV QRDQLREYVK ARLKVFYEEE LDVPLVLFDE VLDHVLRIDR IFRQPQGHLL
LIGVSGAGKT TLSRFVAWMN GLSIFQIKVH NKYTGADFDE DLRSVLRRAG CRDEKVAFIL
DESNVLDSGF LERMNTLLAN GEVPGLFEGD EFAALMTQCK EGAQREGLML DSNDELYKWF
TGQVMRNLHV VFTMNPSSEG LKDRAATSPA LFNRCVLNWF GDWSDGALFQ VGKEFTRRMD
LECAEYVAPA EFPAACGELG ARPSHRDAVV NACVYVHQTL HRANARLAKR ANRTMAITPR
HYLDFIQQMV KLYAEKRADL EEQQLHLNVG LGKIAETVEQ VEEMQKSLAV KSQELQAKNE
AANAKLRQMI KDQHEAEKKK VESQEIQVAL EKQTKEIEAK RRDVMADLAQ VEPAVIEAQN
AVRSIKKQQL VEVRSMANPP SVVKMALESI CTLLGEKGDT WKGIRSVVMK DNFISTIVNF
ETENITIAAD VLTASAPGAP GAHRAYAAVA YVRARLRTSQ RPR
//
