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Database: UniProt
Entry: A0A194Q2B4_PAPXU
LinkDB: A0A194Q2B4_PAPXU
Original site: A0A194Q2B4_PAPXU 
ID   A0A194Q2B4_PAPXU        Unreviewed;      2071 AA.
AC   A0A194Q2B4;
DT   05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 1.
DT   10-MAY-2017, entry version 8.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   ORFNames=RR46_02595 {ECO:0000313|EMBL:KPI99681.1};
OS   Papilio xuthus (Asian swallowtail butterfly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Lepidoptera; Glossata; Ditrysia;
OC   Papilionoidea; Papilionidae; Papilioninae; Papilio.
OX   NCBI_TaxID=66420 {ECO:0000313|EMBL:KPI99681.1, ECO:0000313|Proteomes:UP000053268};
RN   [1] {ECO:0000313|EMBL:KPI99681.1, ECO:0000313|Proteomes:UP000053268}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Ya'a_city_454_Px {ECO:0000313|EMBL:KPI99681.1};
RC   TISSUE=Whole body {ECO:0000313|EMBL:KPI99681.1};
RX   PubMed=26354079; DOI=10.1038/ncomms9212;
RA   Li X., Fan D., Zhang W., Liu G., Zhang L., Zhao L., Fang X., Chen L.,
RA   Dong Y., Chen Y., Ding Y., Zhao R., Feng M., Zhu Y., Feng Y.,
RA   Jiang X., Zhu D., Xiang H., Feng X., Li S., Wang J., Zhang G.,
RA   Kronforst M.R., Wang W.;
RT   "Outbred genome sequencing and CRISPR/Cas9 gene editing in
RT   butterflies.";
RL   Nat. Commun. 6:8212-8212(2015).
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448,
CC       ECO:0000256|RuleBase:RU361132}.
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DR   EMBL; KQ459564; KPI99681.1; -; Genomic_DNA.
DR   Proteomes; UP000053268; Unassembled WGS sequence.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   PROSITE; PS50222; EF_HAND_2; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000053268};
KW   Ion channel {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000313|EMBL:KPI99681.1};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053268};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    133    160       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    204    226       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    238    256       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    262    281       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    392    414       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    819    842       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    863    880       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    892    916       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    947    969       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    989   1006       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1027   1048       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1306   1325       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1346   1365       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1377   1400       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1421   1452       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1539   1565       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1628   1646       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1658   1677       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1689   1708       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1752   1775       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1845   1865       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN     1882   1917       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED       24     49       {ECO:0000256|SAM:Coils}.
FT   COILED      411    467       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2071 AA;  234491 MW;  DF6425235E03B521 CRC64;
     MSEDLDSISE EEQSLFRPFT RDSLAVIEAR IADEHAKQKE LEKKRAEGEV RYDDEDEDEG
     PQPDATLEQG LPLPVRMQGS FPLELASTPL EDIDPFYHNQ RTFVVISKGK DIFRFSATDA
     LWILDPFNPI RRVAIYILVH PLFSLFIITT ILVNCILMIM PTTPTVESTE VIFTGIYTFE
     SAVKVMARGF ILQPFTYLRD AWNWLDFVVI ALAYVTMGID LGNLAALRTF RVLRALKTVA
     IVPGLKTIVG AVIESVKNLR DVIILTMFSL SVFALMGLQI YMGVLTQKCI KVFPEDGSWG
     NLTDENWERF CQNETNWYEE GGEYPLCGNS SGAGQCEPGY VCLQGYGPNP NYGYTSFDTF
     GWAFLSAFRL MTQDYWENLY QLVLRSAGSW HVLFFVVIIF LGSFYLVNLI LAIVAMSYDE
     LQKKAEEEEQ AEEEALREAE QKAAARADKQ EAREAHAREQ AAAAEAAAYA EAHPAKSPSD
     FSCQSYELFV NQERGNQDDN TRERMSLRSD PFQDSVSTQP AHKPADTHHE PARRQRKVSM
     VPHPERINKY GQFYGPLREG SQASLSLPGS PFNLRRGSRG SHQMALRPNG RARYPPGADR
     KPLVLSTYLD AQEHLPYADD SNAVTPMSEE NGAIIIPVYY ANLGSRHSSY TSHQSRLSYT
     SHGDLLGGKA QTKEARLRGR SASRNHSVTS QPHAYALPRP DSSIASRPVR EYEMSTTEST
     DEAGKVLKPS NDNPFIESSQ QPNVVDMRDV MVLNEIIEQA GRQSRASEQN VSVYYFPTAE
     DDEDGPTFKE RLLECLMKGI DFFCVWDCCW LWLEFQKYVA LLVFDPFVEL FITLCIVVNT
     LFMALDHHDM DKDMEKALKS GNYFFTATFG IEAMLKLIAM SPKYYFQEGW NIFDFIIVAL
     SLLELGLEGV QGLSVLRSFR LLRVFKLAKS WPTLNLLISI MGRTMGALGN LTFVLCIIIF
     IFAVMGMQLF GKNYVDYVDR FPDGDLPRWN FTDFMHSFMI VFRVLCGEWI ESMWDCMLVG
     DVSCIPFFLA TVVIGNLVVL NLFLALLLSN FGSSSLSTPT ADQDTNKIAE AFSRISRFID
     WVKRNVADIL KLLKNKLTNQ IAIHAPERVD NELELGADID DGVLYKDKKL KDQVEVAIGD
     GMEFTIPGDN KYKKGKIMLN NINAITDNHT DNRINCELNH HGYPIQDDDT ISQKSYGSHK
     IRSFKDESHK GSADTIDGEE KKDASKEELG LEEEMIEEEE DGKLDGLGKH DIIVAADEDV
     VDDTPADCCP EPCYQRFPFL AGDDESPFWQ GWAMLRLKTF RLIENTYFET AVITMILLSS
     LALALEDVHL PHRPILQDIL YYMDRIFTVI FFIEMLIKWL ALGFQKYFTN AWCWLDFIIV
     MVSLINFVAA LCGAGGIQAF KTMRTLRALR PLRAMSRMQG MRVVVNALVQ AIPSIFNVLL
     VCLIFWLIFA IMGVQLFAGK YFKCVDLNHT TLSHEIIPDR NACILENYTW ENSPMNFDHV
     GKAYLCLFQV ATFKGWIQIM NDAIDSREVG RQPIRETNIY MYLYFVFFII FGSFFTLNLF
     IGVIIDNFNE QKKKAGGSLE MFMTEDQKKY YNAMKKMGSK KPLKAIPRPK WRAQAIVFEI
     VTDKKFDMII MLFIGLNMLT MTLDHYQQSD TFSAVLDYLN MIFIVIFSSE CLLKIFALRY
     HYFVEPWNLF DFVVVMFSIL SLVLSDIIEK YFVSPTLLRV VRVAKVGRVL RLVKGAKGIR
     TLLFALAMSL PALFNICLLL FLVMFIFAIF GMSFFMHVKN KGGLDDVYNF KTFVQSMILL
     FQMSTSAGWD GVLDGIINEE ECDLPDNERG SPGNCGSATI GITYLLSYLV ISFLIVINMY
     IAVILENYSQ ATEDVQEGLT DDDYDMYYEI WQRFDPDGTQ YIRYDQLSDF LDVLEPPLQI
     HKPNKYKIIS MDIPICRGDM MFCVDILDAL TKDFFARKGN PIEETGDLEV GRPDEAGYEP
     VSSTLWRQRE EYCARLIQHA WRRHRRAHDE PASEGGAGGE SGAGGDGAGA GEGAPTAVLL
     DGVAGNGHRV VLQGGGAAPR PPEPAPPPAP V
//
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