ID A0A194Q928_PAPXU Unreviewed; 826 AA.
AC A0A194Q928;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A {ECO:0000256|ARBA:ARBA00040922};
DE EC=2.4.99.18 {ECO:0000256|ARBA:ARBA00012605};
GN ORFNames=RR46_03295 {ECO:0000313|EMBL:KPI99925.1};
OS Papilio xuthus (Asian swallowtail butterfly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Papilionoidea;
OC Papilionidae; Papilioninae; Papilio.
OX NCBI_TaxID=66420 {ECO:0000313|EMBL:KPI99925.1, ECO:0000313|Proteomes:UP000053268};
RN [1] {ECO:0000313|EMBL:KPI99925.1, ECO:0000313|Proteomes:UP000053268}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ya'a_city_454_Px {ECO:0000313|EMBL:KPI99925.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:KPI99925.1};
RX PubMed=26354079; DOI=10.1038/ncomms9212;
RA Li X., Fan D., Zhang W., Liu G., Zhang L., Zhao L., Fang X., Chen L.,
RA Dong Y., Chen Y., Ding Y., Zhao R., Feng M., Zhu Y., Feng Y., Jiang X.,
RA Zhu D., Xiang H., Feng X., Li S., Wang J., Zhang G., Kronforst M.R.,
RA Wang W.;
RT "Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.";
RL Nat. Commun. 6:8212-8212(2015).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a dolichyl diphosphooligosaccharide + L-asparaginyl-[protein]
CC = a dolichyl diphosphate + H(+) + N(4)-(oligosaccharide-(1->4)-N-
CC acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)-L-
CC asparaginy-[protein]; Xref=Rhea:RHEA:22980, Rhea:RHEA-COMP:9529,
CC Rhea:RHEA-COMP:12635, Rhea:RHEA-COMP:12804, Rhea:RHEA-COMP:12805,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:50347, ChEBI:CHEBI:57497,
CC ChEBI:CHEBI:57570, ChEBI:CHEBI:132529; EC=2.4.99.18;
CC Evidence={ECO:0000256|ARBA:ARBA00034064};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- PATHWAY: Protein modification; protein glycosylation.
CC {ECO:0000256|ARBA:ARBA00004922}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004477}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the STT3 family.
CC {ECO:0000256|ARBA:ARBA00010810}.
CC -!- SIMILARITY: Belongs to the peptidase S10 family.
CC {ECO:0000256|ARBA:ARBA00009431}.
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DR EMBL; KQ459551; KPI99925.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A194Q928; -.
DR STRING; 66420.A0A194Q928; -.
DR UniPathway; UPA00378; -.
DR Proteomes; UP000053268; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004579; F:dolichyl-diphosphooligosaccharide-protein glycotransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004185; F:serine-type carboxypeptidase activity; IEA:InterPro.
DR GO; GO:0006486; P:protein glycosylation; IEA:UniProtKB-UniPathway.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR003674; Oligo_trans_STT3.
DR InterPro; IPR001563; Peptidase_S10.
DR InterPro; IPR048307; STT3_N.
DR PANTHER; PTHR13872; DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT; 1.
DR PANTHER; PTHR13872:SF43; DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT STT3A; 1.
DR Pfam; PF00450; Peptidase_S10; 1.
DR Pfam; PF02516; STT3; 1.
DR PRINTS; PR00724; CRBOXYPTASEC.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Manganese {ECO:0000256|ARBA:ARBA00023211};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000053268};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:KPI99925.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 21..41
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 88..108
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 120..140
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 146..163
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 175..197
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 22..196
FT /note="Oligosaccharyl transferase STT3 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02516"
FT REGION 246..279
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 256..272
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 826 AA; 93692 MW; A072A19048F8E932 CRC64;
MTVETQPKAK LPYLSSDKQL TFIKLAVLSM AAILSFATRL FSVLRFESVI HEFDPYFNYR
TTRYLTEEGF YNFHNWFDDR AWYPLGRIIG GTIYPGLMVT SATLYNIMQF LNITIDIRNV
CVFLAPFFSS LTTIVTYLLT KELKDEGAGL VAAAMIAIVP GYISRSVAGS YDNEGIAIFC
MLLTYYFWIK AIITLSVSTE GITVSPSLCP TNKIAPHRRV LTSSYGTQRT FGAFYDLLVP
DNLQSNRPSL QEEPLNDPED CGEIDDYDEN DVGSATTESG RRHSIDNRFF LGNFFSFLRP
PTDGYPSVLQ PGRPGRPTRP PYGSGGYFSG NYYHPPSHIR PSDYVKPVHE DAQETTAAYR
PGVVGAPLGH VVGVTQVRPT NRPPETTSKL NSKYINNIQF STLTQGNSNR RPRDRIINYA
NNNEHNPYLD TLKIFRWKSV QKYVEVRPGA FLFYWFYYAD GTSVGADKKP LIIWIQGGPG
LAASGIANFA EIGPIDMNMQ SRNHTWVKGR NLLLIDHPVG TGFSYVTNKS LLVKTDRQMA
LDLTKVIKAF FKTHKQFRKT PTYLFGQSYG GKLCPRLGVY LHTAIEKKRL KMNLRGIGIG
SGWVDPKEST LVQPSFLYTM GVIDITTYEK TTNLVKKMVN YIDKKDYVYT EKLNTLMFRI
LNMEAGMEIN FNNVNQASPY PALDELARKV NEYVKPTLTL VNQSLQWNYI SDDAFFTLNN
AFFVPSTSFL EKLLNKTSLK IAVYNGNLDV VTPLAGASNW VHKLRWHGAE QFRNAERVRI
NGYRNGFYKK AYQLSFWSVF GSGHWVPEEN PVAMEQILNY VMSEEL
//