ID A0A194Q9T8_PAPXU Unreviewed; 443 AA.
AC A0A194Q9T8;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 08-NOV-2023, entry version 24.
DE SubName: Full=Frizzled-2 {ECO:0000313|EMBL:KPJ02184.1};
GN ORFNames=RR46_03459 {ECO:0000313|EMBL:KPJ02184.1};
OS Papilio xuthus (Asian swallowtail butterfly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Papilionoidea;
OC Papilionidae; Papilioninae; Papilio.
OX NCBI_TaxID=66420 {ECO:0000313|EMBL:KPJ02184.1, ECO:0000313|Proteomes:UP000053268};
RN [1] {ECO:0000313|EMBL:KPJ02184.1, ECO:0000313|Proteomes:UP000053268}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ya'a_city_454_Px {ECO:0000313|EMBL:KPJ02184.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:KPJ02184.1};
RX PubMed=26354079; DOI=10.1038/ncomms9212;
RA Li X., Fan D., Zhang W., Liu G., Zhang L., Zhao L., Fang X., Chen L.,
RA Dong Y., Chen Y., Ding Y., Zhao R., Feng M., Zhu Y., Feng Y., Jiang X.,
RA Zhu D., Xiang H., Feng X., Li S., Wang J., Zhang G., Kronforst M.R.,
RA Wang W.;
RT "Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.";
RL Nat. Commun. 6:8212-8212(2015).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor Fz/Smo family.
CC {ECO:0000256|ARBA:ARBA00008077}.
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DR EMBL; KQ459252; KPJ02184.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A194Q9T8; -.
DR STRING; 66420.A0A194Q9T8; -.
DR Proteomes; UP000053268; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR CDD; cd07456; CRD_FZ5_like; 1.
DR Gene3D; 1.10.2000.10; Frizzled cysteine-rich domain; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR015526; Frizzled/SFRP.
DR InterPro; IPR000539; Frizzled/Smoothened_7TM.
DR InterPro; IPR020067; Frizzled_dom.
DR InterPro; IPR036790; Frizzled_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR PANTHER; PTHR11309; FRIZZLED; 1.
DR PANTHER; PTHR11309:SF126; FRIZZLED-2; 1.
DR Pfam; PF01534; Frizzled; 1.
DR Pfam; PF01392; Fz; 1.
DR PRINTS; PR00489; FRIZZLED.
DR SMART; SM00063; FRI; 1.
DR SMART; SM01330; Frizzled; 1.
DR SUPFAM; SSF63501; Frizzled cysteine-rich domain; 1.
DR PROSITE; PS50038; FZ; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00090}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000053268};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 256..280
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 292..312
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 324..344
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 54..175
FT /note="FZ"
FT /evidence="ECO:0000259|PROSITE:PS50038"
FT DOMAIN 256..429
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 176..200
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 59..120
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 67..113
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 104..142
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 131..172
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 135..159
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
SQ SEQUENCE 443 AA; 48419 MW; 5E4728B0529A76F7 CRC64;
MPIIGSRSID TAVARFDLTD AVSLVRAMFV GVRCAWSALA ALAAFSWLVG CSALQQPRCE
EITIPMCRGI GYNLTSFPNA LDHDTQEEAG LEVHQYWPLV EIKCSPDLKF FLCSVYTPIC
IEDYAKPLPA CRSVCERARA GCAPLMQKYG FQWPERMACE KLPKMGEPDQ LCMDENERAQ
EPEPPRPPPR RPHKPCKDPK NCESAAGGEG GGEECACACR APLVSVRAHN ASVPGLANCA
APCRGPFFSR EEKEFAAVWI ALWSGLCAIS TLMTLTTFLI DSQRFKYPER PIVYLSACYF
MVALGYLARL VLGHDEIACD GAVIKTSANG PSACTLVFIL VYFFGMASSI WWVVLSFAWF
LAAGLKWGNE AIAGHAQYYH LAAWLVPAAK TVAVLLAGAV DGDPVAGICY VGNSSPENLK
KYVLAPLIVC FTAYLKFSEI HKT
//
