ID   A0A194QES0_PAPXU        Unreviewed;       848 AA.
AC   A0A194QES0;
DT   05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   SubName: Full=Retinoblastoma-like protein 1 {ECO:0000313|EMBL:KPJ03977.1};
GN   ORFNames=RR46_07736 {ECO:0000313|EMBL:KPJ03977.1};
OS   Papilio xuthus (Asian swallowtail butterfly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Papilionoidea;
OC   Papilionidae; Papilioninae; Papilio.
OX   NCBI_TaxID=66420 {ECO:0000313|EMBL:KPJ03977.1, ECO:0000313|Proteomes:UP000053268};
RN   [1] {ECO:0000313|EMBL:KPJ03977.1, ECO:0000313|Proteomes:UP000053268}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Ya'a_city_454_Px {ECO:0000313|EMBL:KPJ03977.1};
RC   TISSUE=Whole body {ECO:0000313|EMBL:KPJ03977.1};
RX   PubMed=26354079; DOI=10.1038/ncomms9212;
RA   Li X., Fan D., Zhang W., Liu G., Zhang L., Zhao L., Fang X., Chen L.,
RA   Dong Y., Chen Y., Ding Y., Zhao R., Feng M., Zhu Y., Feng Y., Jiang X.,
RA   Zhu D., Xiang H., Feng X., Li S., Wang J., Zhang G., Kronforst M.R.,
RA   Wang W.;
RT   "Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.";
RL   Nat. Commun. 6:8212-8212(2015).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the retinoblastoma protein (RB) family.
CC       {ECO:0000256|ARBA:ARBA00009475}.
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DR   EMBL; KQ459053; KPJ03977.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A194QES0; -.
DR   STRING; 66420.A0A194QES0; -.
DR   Proteomes; UP000053268; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051172; P:negative regulation of nitrogen compound metabolic process; IEA:UniProt.
DR   GO; GO:0051726; P:regulation of cell cycle; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   Gene3D; 1.10.472.140; -; 1.
DR   Gene3D; 1.10.472.10; Cyclin-like; 3.
DR   InterPro; IPR036915; Cyclin-like_sf.
DR   InterPro; IPR002720; RB_A.
DR   InterPro; IPR002719; RB_B.
DR   InterPro; IPR028309; RB_fam.
DR   InterPro; IPR024599; RB_N.
DR   PANTHER; PTHR13742:SF36; RE32990P-RELATED; 1.
DR   PANTHER; PTHR13742; RETINOBLASTOMA-ASSOCIATED PROTEIN RB -RELATED; 1.
DR   Pfam; PF11934; DUF3452; 1.
DR   Pfam; PF01858; RB_A; 1.
DR   Pfam; PF01857; RB_B; 1.
DR   SMART; SM01367; DUF3452; 1.
DR   SMART; SM01368; RB_A; 1.
DR   SUPFAM; SSF47954; Cyclin-like; 2.
PE   3: Inferred from homology;
KW   Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053268};
KW   Repressor {ECO:0000256|ARBA:ARBA00022491};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT   DOMAIN          64..208
FT                   /note="Retinoblastoma-associated protein N-terminal"
FT                   /evidence="ECO:0000259|SMART:SM01367"
FT   DOMAIN          372..565
FT                   /note="Retinoblastoma-associated protein A-box"
FT                   /evidence="ECO:0000259|SMART:SM01368"
SQ   SEQUENCE   848 AA;  95775 MW;  71A5840195F01A3F CRC64;
     MSKPEESEEN WISALDNLCS QLNVDPAAAE KSKKSFLEIK RNYTLDGDIQ HWMACALYVA
     CRTSITPTVQ SGKVVEGNCV SLTRLLRLCN ISLIQFFNKI KNWMEMALMS TDFKDRITRL
     EHKFAVSTVL FRKFLPIFQE LFSGLTSEPT KCNTKSKKQK LQPCTTNALF EFSWCLYVCV
     KGEFHNSADD LVDMYHVLLS CLDFVFGNAF MSRRIDLINP AFKGLPPDWM KDDFELPKKP
     PCIISVLCEI KEGLAVEAAT MKEYSWRPVI KSFFDKGILK GNSDQLTGLL DIGNFDANLK
     SLNNLYETYV LSVGEFDERI FLGEHANEQI GTKKVSGEEI SQVIASFGPS GRACPDTPLT
     GRCYLAGREE LTPVSEATNS LARLAAYLRN TKPFPSASLM RLFAECGVTE DVINAKVIKP
     CNGWAEQFSK SLRESKCSNE AITFRNNMVL CLYFKVFEHI IREEHRKKPQ VSLQMLLSQE
     TYQLTVFACC TEVVLHAYGV NSLRFPRVLQ IFGLSAFHFY KIIELVVQAL VDKLSRDVIK
     HLNAVEEEVL ESLVWTSDSP LWDQLSKTPV PASTEVYVQE SPLFRRNIGV IDRYLAPIAD
     QAKKQLFKDN IKPGQSLLVQ TNTTVKPDTV CPSPTSNGET TPNSTPKKAH NSLILFFRKF
     YSLAVVRMID LCTRLRLTDE ELKRKIWTCL EYSVMHQTQL MRDRHLDQIL MCAVYVSNNP
     NNQVERTFAD IMKCYRQRPL ADNHECGLSP LPAGRGDAAC SPAGQRVSER HQLYVKPLTT
     PPHTDHHLTY RFSRSPAKDL HAINTLVSCE VGGVKRCAEG GDVIKRPRCA APGVARKLQG
     LVSDRQAV
//