ID A0A194QVZ8_PAPMA Unreviewed; 836 AA.
AC A0A194QVZ8;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Glutamate receptor 1 {ECO:0000313|EMBL:KPJ09140.1};
GN ORFNames=RR48_15281 {ECO:0000313|EMBL:KPJ09140.1};
OS Papilio machaon (Old World swallowtail butterfly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Papilionoidea;
OC Papilionidae; Papilioninae; Papilio.
OX NCBI_TaxID=76193 {ECO:0000313|EMBL:KPJ09140.1, ECO:0000313|Proteomes:UP000053240};
RN [1] {ECO:0000313|EMBL:KPJ09140.1, ECO:0000313|Proteomes:UP000053240}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ya'a_city_454_Pm {ECO:0000313|EMBL:KPJ09140.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:KPJ09140.1};
RX PubMed=26354079; DOI=10.1038/ncomms9212;
RA Li X., Fan D., Zhang W., Liu G., Zhang L., Zhao L., Fang X., Chen L.,
RA Dong Y., Chen Y., Ding Y., Zhao R., Feng M., Zhu Y., Feng Y., Jiang X.,
RA Zhu D., Xiang H., Feng X., Li S., Wang J., Zhang G., Kronforst M.R.,
RA Wang W.;
RT "Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.";
RL Nat. Commun. 6:8212-8212(2015).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the glutamate-gated ion channel (TC 1.A.10.1)
CC family. {ECO:0000256|ARBA:ARBA00008685}.
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DR EMBL; KQ461108; KPJ09140.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A194QVZ8; -.
DR STRING; 76193.A0A194QVZ8; -.
DR InParanoid; A0A194QVZ8; -.
DR Proteomes; UP000053240; Unassembled WGS sequence.
DR GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-KW.
DR GO; GO:0015276; F:ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR GO; GO:0007154; P:cell communication; IEA:UniProt.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 2.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR019594; Glu/Gly-bd.
DR InterPro; IPR001508; Iono_Glu_rcpt_met.
DR InterPro; IPR015683; Ionotropic_Glu_rcpt.
DR InterPro; IPR001320; Iontro_rcpt_C.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR18966:SF600; GLUTAMATE RECEPTOR 1-RELATED; 1.
DR PANTHER; PTHR18966; IONOTROPIC GLUTAMATE RECEPTOR; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF00060; Lig_chan; 1.
DR Pfam; PF10613; Lig_chan-Glu_bd; 1.
DR PRINTS; PR00177; NMDARECEPTOR.
DR SMART; SM00918; Lig_chan-Glu_bd; 1.
DR SMART; SM00079; PBPe; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00023257};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:KPJ09140.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000053240};
KW Synapse {ECO:0000256|ARBA:ARBA00023018};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 490..509
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 576..599
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 737..760
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 363..717
FT /note="Ionotropic glutamate receptor C-terminal"
FT /evidence="ECO:0000259|SMART:SM00079"
FT DOMAIN 373..436
FT /note="Ionotropic glutamate receptor L-glutamate and
FT glycine-binding"
FT /evidence="ECO:0000259|SMART:SM00918"
SQ SEQUENCE 836 AA; 95168 MW; FD6331034744B2B9 CRC64;
MKDKAKCLAR ISVTTTTKER QWPWALTSDD DKRTRESNHA FTSWVQTPPC IKVFFVFNFS
DILTVKENIQ PAISAKKFKD MCDVNQPALG RCGCLWPSRH GLLRLQQLYE RLQPGNATFR
ISNVKRVSNG TDVVEFLGAL EKLDRWTNKY VVLDSSTRIA KEALILHVRN VQLGRRNYHY
FLSGLVMDDR WEKQVTEFGA INVTGFRIVD FSRKFVRNFS EMWRRDTISA QAALMYDGVQ
VLIDAIFRLL RKRPDILRGL SRRSASSSSN KTLDCTPRIG TGTYEIGDKI ARLIKKTDLE
GLTGPLKFND KGVRRNFSLQ VVEMTVAGEM VKIGTWYDYK GLITKNKRPG AKSAVGKYNR
NKTYIVSTIE EPPYVIRDLE PTVTYPFRGF CVDLTHMVFE KLEINYELRT VKDGKYGKEN
TKFAGGWDGM VGELLRKEAD LVIAPLIVTA EREHVIDFSK PFLSFDSKPE RPDFENTNTI
FSFLHPLSKE IWLCILFSIF AVSVVLFIVS RFSPSEWRLV SVTDSQSNEH NEVSTTKTTV
INEFSFWNSI WFSIGSFMQQ GSDISPRSLS GRIVGAVWWF FTLVVICSYT ANLASYLTLA
RISEPTQLYN KITTCPEDII YGQQEPELIE PPTTETTGVV DEHGWLAFLL DRSAMGLKRN
NIDKPCEMLV TTTKQGVIDF AIAFPKGSEL RDGINIILQN LKKEGDLQML LRKWFIKTEC
DVPDQSLRGL ELTLGQIAGL FYILMGGLVL ALAVALFEFF HYGRAEAARA NIPLRAAFKA
KSRLPNRLEI KTTQRPAPQR DQDRLDWNSG PYSGYYTPAN QIAQEETALQ ASFTQV
//
