ID A0A194QW37_PAPMA Unreviewed; 865 AA.
AC A0A194QW37;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Discoidin domain-containing receptor 2 {ECO:0000313|EMBL:KPJ09180.1};
GN ORFNames=RR48_15321 {ECO:0000313|EMBL:KPJ09180.1};
OS Papilio machaon (Old World swallowtail butterfly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Papilionoidea;
OC Papilionidae; Papilioninae; Papilio.
OX NCBI_TaxID=76193 {ECO:0000313|EMBL:KPJ09180.1, ECO:0000313|Proteomes:UP000053240};
RN [1] {ECO:0000313|EMBL:KPJ09180.1, ECO:0000313|Proteomes:UP000053240}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ya'a_city_454_Pm {ECO:0000313|EMBL:KPJ09180.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:KPJ09180.1};
RX PubMed=26354079; DOI=10.1038/ncomms9212;
RA Li X., Fan D., Zhang W., Liu G., Zhang L., Zhao L., Fang X., Chen L.,
RA Dong Y., Chen Y., Ding Y., Zhao R., Feng M., Zhu Y., Feng Y., Jiang X.,
RA Zhu D., Xiang H., Feng X., Li S., Wang J., Zhang G., Kronforst M.R.,
RA Wang W.;
RT "Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.";
RL Nat. Commun. 6:8212-8212(2015).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
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DR EMBL; KQ461108; KPJ09180.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A194QW37; -.
DR InParanoid; A0A194QW37; -.
DR Proteomes; UP000053240; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW.
DR CDD; cd00057; FA58C; 1.
DR CDD; cd12087; TM_EGFR-like; 1.
DR Gene3D; 2.60.120.1190; -; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR048525; DDR1-2_DS-like.
DR InterPro; IPR000421; FA58C.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR008266; Tyr_kinase_AS.
DR InterPro; IPR020635; Tyr_kinase_cat_dom.
DR PANTHER; PTHR24416:SF579; TYROSINE-PROTEIN KINASE ABL-LIKE PROTEIN; 1.
DR PANTHER; PTHR24416; TYROSINE-PROTEIN KINASE RECEPTOR; 1.
DR Pfam; PF21114; DDR1-2_DS-like; 1.
DR Pfam; PF00754; F5_F8_type_C; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR PRINTS; PR00109; TYRKINASE.
DR SMART; SM00231; FA58C; 1.
DR SMART; SM00219; TyrKc; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS01286; FA58C_2; 1.
DR PROSITE; PS50022; FA58C_3; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
PE 4: Predicted;
KW Kinase {ECO:0000256|ARBA:ARBA00023137}; Membrane {ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:KPJ09180.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000053240};
KW Transferase {ECO:0000256|ARBA:ARBA00023137};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Tyrosine-protein kinase {ECO:0000256|ARBA:ARBA00023137}.
FT TRANSMEM 386..410
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 19..175
FT /note="F5/8 type C"
FT /evidence="ECO:0000259|PROSITE:PS50022"
FT DOMAIN 587..855
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 524..564
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 865 AA; 97630 MW; E2BECAB48D584343 CRC64;
MQQLPLFILI AELNKTAQCI APLGMENGLI PDKDLTASSS FNDGNVGPQN GRLNQEIKGG
AWCPKSQITT ESTEWLEVNL HTVHVITGAG TQGRFGNGQG QEYAEAYVLE YWRPKLGKWV
RYRGADGQEI LTGNANTYLE KKNHLQPPIW ASKIRFIPYS SHRRTVCMRV ELYGCYWSVG
IVAYSMPKGD KRSNGIELTD MTYDGQWGEE LRGGLGQLVD GQYGGDEIRE AARNSAWVGW
KKESRPNPPV ITFEFDKVRE FSAVHFYCNN RFMRDVQVFS EAIISFSIGG RHFQDEPIRY
SYVEDSIFES SRNVSIKLHH RIGKWVRIEL RFAASWILIS EVVFDSDVAQ GNYTPETVKA
TGGKEKTKSS TTKDLPISTA HQEDPLYMAI VVGVLTALVI LLAVAVFLIV HRHRHRKCFA
SPLAKSTISQ KRTVTDTYNP CGTSMMPDNK MILDCGLDVK SDEYQEPYQA LKCAPYFSYS
TVLLEMKDFV KDSSTPLSDS SNYEYAVPEL SSAPLLTKRR LADSLSGRTT DPLTDHDPEM
GLGARRSAPA SIRSKHSTRS PSQQEVLTDL KRRLETTNVI EFPRHRLRMI SKLAEGAFGT
VYVAEADGVP EYNGIVTSEK RLVAVKFLCH DATPKEREDF ERDVRILAAL SSPHLARVLG
ACRTPPLAVV LEYLELGDLC AFLRSAPPPS IGSLLHIATQ IATGMQYLES LNFVHRDLAA
RNILIGKGYQ IKISDFGTDN EAYICDYYKV EGRVPIPLRW AAWETLLGHY TTKSDVWAFA
VTLHEIFTFC RRRPYEHLTD NEVLENLAHL QADDGLFECI ERAPGIPRDL YELMRECWKH
DQLERPDFVE VNLFLQRKSL NHATT
//
