ID A0A194R4E5_PAPMA Unreviewed; 529 AA.
AC A0A194R4E5;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=unspecific monooxygenase {ECO:0000256|ARBA:ARBA00012109};
DE EC=1.14.14.1 {ECO:0000256|ARBA:ARBA00012109};
GN ORFNames=RR48_11650 {ECO:0000313|EMBL:KPJ12394.1};
OS Papilio machaon (Old World swallowtail butterfly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Papilionoidea;
OC Papilionidae; Papilioninae; Papilio.
OX NCBI_TaxID=76193 {ECO:0000313|EMBL:KPJ12394.1, ECO:0000313|Proteomes:UP000053240};
RN [1] {ECO:0000313|EMBL:KPJ12394.1, ECO:0000313|Proteomes:UP000053240}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ya'a_city_454_Pm {ECO:0000313|EMBL:KPJ12394.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:KPJ12394.1};
RX PubMed=26354079; DOI=10.1038/ncomms9212;
RA Li X., Fan D., Zhang W., Liu G., Zhang L., Zhao L., Fang X., Chen L.,
RA Dong Y., Chen Y., Ding Y., Zhao R., Feng M., Zhu Y., Feng Y., Jiang X.,
RA Zhu D., Xiang H., Feng X., Li S., Wang J., Zhang G., Kronforst M.R.,
RA Wang W.;
RT "Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.";
RL Nat. Commun. 6:8212-8212(2015).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=an organic molecule + O2 + reduced [NADPH--hemoprotein
CC reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein
CC reductase]; Xref=Rhea:RHEA:17149, Rhea:RHEA-COMP:11964, Rhea:RHEA-
CC COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379,
CC ChEBI:CHEBI:30879, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210,
CC ChEBI:CHEBI:142491; EC=1.14.14.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001025};
CC -!- COFACTOR:
CC Name=heme; Xref=ChEBI:CHEBI:30413;
CC Evidence={ECO:0000256|ARBA:ARBA00001971};
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004406}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004406}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}. Microsome membrane
CC {ECO:0000256|ARBA:ARBA00004174}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004174}.
CC -!- SIMILARITY: Belongs to the cytochrome P450 family.
CC {ECO:0000256|ARBA:ARBA00010617, ECO:0000256|RuleBase:RU000461}.
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DR EMBL; KQ460779; KPJ12394.1; -; Genomic_DNA.
DR RefSeq; XP_014362122.1; XM_014506636.1.
DR AlphaFoldDB; A0A194R4E5; -.
DR STRING; 76193.A0A194R4E5; -.
DR GeneID; 106713777; -.
DR KEGG; pmac:106713777; -.
DR InParanoid; A0A194R4E5; -.
DR OrthoDB; 3094192at2759; -.
DR Proteomes; UP000053240; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.
DR GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR CDD; cd11056; CYP6-like; 1.
DR Gene3D; 1.10.630.10; Cytochrome P450; 1.
DR InterPro; IPR001128; Cyt_P450.
DR InterPro; IPR017972; Cyt_P450_CS.
DR InterPro; IPR002401; Cyt_P450_E_grp-I.
DR InterPro; IPR036396; Cyt_P450_sf.
DR PANTHER; PTHR24292; CYTOCHROME P450; 1.
DR PANTHER; PTHR24292:SF105; CYTOCHROME P450 9AC1; 1.
DR Pfam; PF00067; p450; 1.
DR PRINTS; PR00463; EP450I.
DR PRINTS; PR00385; P450.
DR SUPFAM; SSF48264; Cytochrome P450; 1.
DR PROSITE; PS00086; CYTOCHROME_P450; 1.
PE 3: Inferred from homology;
KW Heme {ECO:0000256|RuleBase:RU000461};
KW Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|RuleBase:RU000461};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU000461};
KW Monooxygenase {ECO:0000256|ARBA:ARBA00023033,
KW ECO:0000256|RuleBase:RU000461};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|RuleBase:RU000461};
KW Reference proteome {ECO:0000313|Proteomes:UP000053240}.
SQ SEQUENCE 529 AA; 61275 MW; 5F015D9CC792507D CRC64;
MILLVMLSTL AVGLTLYLRH VYSRFRRYGV KSLTPIPILG NMARITFRKE HVSNNTDRIY
DVGPGDRFVG KYEFLDPVVM IKDIDLIKSI TVKDFEHFVD HRKFVDEELD TCFGRNLFSL
KGEEWKMMRS ILSPAFTSFK IRSMVPFMVE VGDKMINSLK MKIENSGKNI IDIDCKELSS
RYANDVIATC AFGLNIDSHA EENNTFYKKG KEAVAFNFKQ LLKFFAVTFW PKVSKLLRIT
LFSEEIRFFF RDLVLGTIRD REENNIVRPD MIHLLMEAKK GNLKHESGKD TDAGFATVEE
SAVGKNNISY VWKDNDLVAQ VLLFFIGGFD TVSTAMTFAM HELAANPEVQ ERLYQEIREY
HHKNKGKIDY NSINELKYLD MVVSEVLRLW PPAITLERLC VKDYNLGKCN EKASKDYVVR
KGESIILPLW SIHRNPTYHP RPLLFDPERF SEERRHLIKP FTYFPFGLGP RNCIGSRFAL
CELKVMLYQL LLHVQVFPCE KTCKPAQLAT DSFSIRMKGG NWVGLKLRQ
//
