ID A0A194R6X9_PAPMA Unreviewed; 1799 AA.
AC A0A194R6X9;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Clathrin heavy chain {ECO:0000256|PIRNR:PIRNR002290};
GN ORFNames=RR48_08363 {ECO:0000313|EMBL:KPJ11621.1};
OS Papilio machaon (Old World swallowtail butterfly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Papilionoidea;
OC Papilionidae; Papilioninae; Papilio.
OX NCBI_TaxID=76193 {ECO:0000313|EMBL:KPJ11621.1, ECO:0000313|Proteomes:UP000053240};
RN [1] {ECO:0000313|EMBL:KPJ11621.1, ECO:0000313|Proteomes:UP000053240}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ya'a_city_454_Pm {ECO:0000313|EMBL:KPJ11621.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:KPJ11621.1};
RX PubMed=26354079; DOI=10.1038/ncomms9212;
RA Li X., Fan D., Zhang W., Liu G., Zhang L., Zhao L., Fang X., Chen L.,
RA Dong Y., Chen Y., Ding Y., Zhao R., Feng M., Zhu Y., Feng Y., Jiang X.,
RA Zhu D., Xiang H., Feng X., Li S., Wang J., Zhang G., Kronforst M.R.,
RA Wang W.;
RT "Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.";
RL Nat. Commun. 6:8212-8212(2015).
CC -!- FUNCTION: Clathrin is the major protein of the polyhedral coat of
CC coated pits and vesicles. {ECO:0000256|PIRNR:PIRNR002290}.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane
CC {ECO:0000256|PIRNR:PIRNR002290}; Peripheral membrane protein
CC {ECO:0000256|PIRNR:PIRNR002290}; Cytoplasmic side
CC {ECO:0000256|PIRNR:PIRNR002290}. Membrane, coated pit
CC {ECO:0000256|PIRNR:PIRNR002290}; Peripheral membrane protein
CC {ECO:0000256|PIRNR:PIRNR002290}; Cytoplasmic side
CC {ECO:0000256|PIRNR:PIRNR002290}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
CC -!- SIMILARITY: Belongs to the clathrin heavy chain family.
CC {ECO:0000256|ARBA:ARBA00009535, ECO:0000256|PIRNR:PIRNR002290}.
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DR EMBL; KQ460878; KPJ11621.1; -; Genomic_DNA.
DR STRING; 76193.A0A194R6X9; -.
DR InParanoid; A0A194R6X9; -.
DR Proteomes; UP000053240; Unassembled WGS sequence.
DR GO; GO:0030132; C:clathrin coat of coated pit; IEA:InterPro.
DR GO; GO:0030130; C:clathrin coat of trans-Golgi network vesicle; IEA:InterPro.
DR GO; GO:0071439; C:clathrin complex; IEA:InterPro.
DR GO; GO:0032051; F:clathrin light chain binding; IEA:InterPro.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:UniProtKB-UniRule.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR Gene3D; 1.25.40.30; -; 1.
DR Gene3D; 1.25.40.730; -; 2.
DR Gene3D; 2.130.10.110; Clathrin heavy-chain terminal domain; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 4.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000547; Clathrin_H-chain/VPS_repeat.
DR InterPro; IPR012331; Clathrin_H-chain_linker.
DR InterPro; IPR015348; Clathrin_H-chain_linker_core.
DR InterPro; IPR016025; Clathrin_H-chain_N.
DR InterPro; IPR022365; Clathrin_H-chain_propeller_rpt.
DR InterPro; IPR016341; Clathrin_heavy_chain.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR10292:SF1; CLATHRIN HEAVY CHAIN; 1.
DR PANTHER; PTHR10292; CLATHRIN HEAVY CHAIN RELATED; 1.
DR Pfam; PF00637; Clathrin; 8.
DR Pfam; PF09268; Clathrin-link; 1.
DR Pfam; PF13838; Clathrin_H_link; 2.
DR Pfam; PF01394; Clathrin_propel; 4.
DR PIRSF; PIRSF002290; Clathrin_H_chain; 5.
DR SMART; SM00299; CLH; 8.
DR SUPFAM; SSF48371; ARM repeat; 7.
DR SUPFAM; SSF50989; Clathrin heavy-chain terminal domain; 1.
DR PROSITE; PS50236; CHCR; 8.
PE 3: Inferred from homology;
KW Coated pit {ECO:0000256|ARBA:ARBA00023176, ECO:0000256|PIRNR:PIRNR002290};
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329,
KW ECO:0000256|PIRNR:PIRNR002290};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR002290};
KW Reference proteome {ECO:0000313|Proteomes:UP000053240};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 237..260
FT /note="Clathrin heavy chain linker core motif"
FT /evidence="ECO:0000259|Pfam:PF09268"
SQ SEQUENCE 1799 AA; 205956 MW; E8077B1B0C012AAF CRC64;
MKSKMKAHTM TEDIVFWKWI SLNTLALVTR VSVYHWSMEG DSTPVKIFDR HSSLADCQII
NYRTDPKQQW LLLVGISAQQ NRVVGAMQLY SVERKCSQPI EGHAASFAKF KAEGNAEPST
LFCFAVRTAQ GGKLHIIEVG QTPAGNQPFP KKAVDVFFPP EAQNDFPVAM QVSPKYDVIY
LITKYGYIHM YDIETGTCIY MNRISSDTIF VTAPHEATGG IIGVNRKGQV LSVTVEEDSI
VPYINTVLQN PELALRLAVR NNLAGAEELF VRKFNMLFTN GQYAEAAKVA AMAPRGILRT
PQTIQRFQQV PTQSGQTSPL LQYFGMLLDQ AQLNKFESLE LCRPVAAMAP RGILRTPQTI
QRFQQVPTQS GQTSPLLQYF GMLLDQAQLN KFESLELCRP VLLQGRKQLL EKWLKEEKLE
CSEELGDLVK PVDLTLALSV YLRANVASKV IQCFAETGQF QKIVLYAKKY RVATRRHGKR
RHASNSVYKL LEMNLMSAPQ VADAILGNGM FTHYDRAHVA QLCEKAGLLQ RALEHYTDLY
DIKRAVVHTH LLSADWLVTY FGTLSVEDSL ECLKAMLQAN IRQNLQICVQ IATKYHEQLT
TKALIELFES FKTYEGLFYF LGSIVNFSQD PEVHFKYIQA ACKTGQIKEV ERICRESNCY
NAERVKNFLK EAKLPDQLPL IIVCDRFDFV HDLVLYLYRN SLQKYIEIYV QKVNPSRLPV
VVGGLLDVDC AEDIIKNLIL VVRGQFSTDE LVAEVEKRNR LKLLLPWLET RVHEGCTEPA
THNALAKIYI DSNNNPERFL KENQWYDSRV VGRYCEKRDP HLACVAYERG QCDRELIAVC
NDNSLFKTQA RYLVRRRDQD LWLEVLAESN PFKRQLIDQV VQTALSETQD PEDISVTVKA
FMTADLPNEL IELLEKIVLD NSVFSDHRNL QNLLILTGKK TLTFPQYDSR VVGRYCEKRD
PHLACVAYER GQCDRELIAV CNDNSLFKTQ ARYLVRRRDQ DLWLEVLAES NPFKRQLIDQ
VVQTALSETQ DPEDISVTVK AFMTADLPNE LIELLEKIVL DNSVFSDHRN LQNLLILTAI
KADRSRVMEY INRLDNYDAP DIANIAINNE LYEEAFAIFK KFDVNTSAIQ VLIEQVKDLK
RAYEFAERCN EPGVWSQLAK AQLQQGLVKE AIDSYIKADD PSAYMDVVDT ATKQQSWEDL
MARKKARESY IESELIYAYA RTGRLADLEE FISGPNHADI QKIGDRCFED KMYNAAKLLY
NNVSNFARLA ITLVHLKEFQ GAVDSARKAN STRTWKEVCF ACVDAGEFRL AQMCGLHIVV
HADELEDLIN YYQDRGHFDE LISLLEAALG LERAHMGMFT ELAILYSKYK TAKMREHLEL
FWSRVNIPKV LRAAEQAHLW SELVFLYDKY EEYDNAALTM MQHPTEAWRE GHFKDIITKV
ANMELYYKAI QFYLDYKPLL LNDLLLVLAP RMDHTRAVNF FTKAGHLQLV KAYLRSVQSL
NNKAVNEALN SLLIDEEDYQ GLRTSIDAFD NFDTIALAQQ LEKHELTEFR RIAAYLYKGN
NRWKQSVELC KKDALYADAM EYAAESRQSD VAEELLNWFL ERDNFECFSA CLYQCYDLLK
PDVVIELAWR HNIMDFAMPF LIQTVRELTT KVEKLEEADA KRSTESAEHE AKPAMMMEPQ
LMLTAGTYSL KKRSPCYDLL KPDVVIELAW RHNIMDFAMP FLIQTVRELT TKVEKLEEAD
AKRSTESAEH EAKPAMMMEP QLMLTAGPSM AYPGVAAQAS PYAYAAQAPS PAPYHGYGM
//
