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Database: UniProt
Entry: A0A194RCX9_PAPMA
LinkDB: A0A194RCX9_PAPMA
Original site: A0A194RCX9_PAPMA 
ID   A0A194RCX9_PAPMA        Unreviewed;       804 AA.
AC   A0A194RCX9;
DT   05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 1.
DT   27-SEP-2017, entry version 7.
DE   SubName: Full=Pancreatic triacylglycerol lipase {ECO:0000313|EMBL:KPJ13766.1};
GN   ORFNames=RR48_10950 {ECO:0000313|EMBL:KPJ13766.1};
OS   Papilio machaon (Old World swallowtail butterfly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Lepidoptera; Glossata; Ditrysia;
OC   Papilionoidea; Papilionidae; Papilioninae; Papilio.
OX   NCBI_TaxID=76193 {ECO:0000313|EMBL:KPJ13766.1, ECO:0000313|Proteomes:UP000053240};
RN   [1] {ECO:0000313|EMBL:KPJ13766.1, ECO:0000313|Proteomes:UP000053240}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Ya'a_city_454_Pm {ECO:0000313|EMBL:KPJ13766.1};
RC   TISSUE=Whole body {ECO:0000313|EMBL:KPJ13766.1};
RX   PubMed=26354079; DOI=10.1038/ncomms9212;
RA   Li X., Fan D., Zhang W., Liu G., Zhang L., Zhao L., Fang X., Chen L.,
RA   Dong Y., Chen Y., Ding Y., Zhao R., Feng M., Zhu Y., Feng Y.,
RA   Jiang X., Zhu D., Xiang H., Feng X., Li S., Wang J., Zhang G.,
RA   Kronforst M.R., Wang W.;
RT   "Outbred genome sequencing and CRISPR/Cas9 gene editing in
RT   butterflies.";
RL   Nat. Commun. 6:8212-8212(2015).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00553472}.
CC   -!- SIMILARITY: Belongs to the AB hydrolase superfamily. Lipase
CC       family. {ECO:0000256|RuleBase:RU004262,
CC       ECO:0000256|SAAS:SAAS00591292}.
CC   -!- SIMILARITY: Belongs to the amiloride-sensitive sodium channel
CC       (TC 1.A.6) family. {ECO:0000256|RuleBase:RU000679}.
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DR   EMBL; KQ460615; KPJ13766.1; -; Genomic_DNA.
DR   Proteomes; UP000053240; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0052689; F:carboxylic ester hydrolase activity; IEA:InterPro.
DR   GO; GO:0005272; F:sodium channel activity; IEA:UniProtKB-KW.
DR   GO; GO:0006629; P:lipid metabolic process; IEA:InterPro.
DR   CDD; cd00707; Pancreat_lipase_like; 1.
DR   Gene3D; 3.40.50.1820; -; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR001873; ENaC.
DR   InterPro; IPR013818; Lipase/vitellogenin.
DR   InterPro; IPR033906; Lipase_N.
DR   InterPro; IPR000734; TAG_lipase.
DR   PANTHER; PTHR11610; PTHR11610; 1.
DR   Pfam; PF00858; ASC; 1.
DR   Pfam; PF00151; Lipase; 1.
DR   PRINTS; PR00821; TAGLIPASE.
DR   SUPFAM; SSF53474; SSF53474; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000053240};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS00709807};
KW   Ion channel {ECO:0000256|RuleBase:RU000679};
KW   Ion transport {ECO:0000256|RuleBase:RU000679};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053240};
KW   Secreted {ECO:0000256|SAAS:SAAS00439306};
KW   Sodium {ECO:0000256|RuleBase:RU000679};
KW   Sodium channel {ECO:0000256|RuleBase:RU000679};
KW   Sodium transport {ECO:0000256|RuleBase:RU000679};
KW   Transmembrane {ECO:0000256|RuleBase:RU000679,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU000679}.
FT   TRANSMEM    761    788       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       68    380       Lipase. {ECO:0000259|Pfam:PF00151}.
SQ   SEQUENCE   804 AA;  90730 MW;  D7906E4927AD08E8 CRC64;
     MLAQYDLVHM ENHISPEDLE EFLNWHHKKH NGTDTSTDDY GSMEPVTDFP ESEEVDCFGL
     GSFASQLINM RPDTSENINT HFYFSSRQNP NRVQVFPGDQ FGLEWVDFKP NRRTIMIVHG
     FMSHSNASWV TAMTNAFLQW GDVNVIAVDW SQGGNTWKYW RAVANTRTVG GDVTGFMQQL
     MKETGANAKD FHFVGHSLGA HIVSYVSYHL GRVSRITGLD PAQPCFRTNN LVERLDSTDA
     DFVDVIHTNG RLLSKIGFGF PDPTGHADFY PNGGMKQPGC FNTTSSLWAR LLPIPVGILQ
     QAVCSHGRAY LLFIESLVNN NCSFRGHQWN LTYEGVNASI VAACDRVGAC SEMGIRAIGG
     NGLPRATGAY FVLTTATEPY CPTDWERRHP QPELLRDLRE GFRLDRSVKA VVTDTYADPM
     ATKPPPAKST FFSWWQTSKR PHEFAETFTI ADALPTANRR RRRRTKREYL TFLCISSSIK
     STSPSHPKDK DKTTKIRPPV PHSSDEMRNC FHLTPVFCVD VVHKQCEELI TDCSFNHKQF
     RCCDKFFPVD SESGPGISFN SLQHMENDHD KLFNVNQSTG PGVLTFRLLS DAQISIHSPE
     ELSTKLLDNK FKIDVDLNYH NHVDILFSIV EVENDPLLQF ETPNVRGCRY LEEVPNGFMH
     TYPVYSNGAC RLARNTERSY QQCGCVHPVR DISCEKVKLG VDKGNNDSCL PSCVESELTI
     VHTSMRRVPK QAKRGSLINI SMISLPTLRY RKNLLRNDLD LVVTVGGMLG LFFSASVLSL
     AEAIYLIIRQ PNKELLLFTL SIKL
//
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