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Database: UniProt
Entry: A0A199NTI5_9MICC
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ID   A0A199NTI5_9MICC        Unreviewed;       577 AA.
AC   A0A199NTI5;
DT   05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 1.
DT   25-OCT-2017, entry version 12.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=AN277_0203285 {ECO:0000313|EMBL:OAX52394.1};
OS   Kocuria kristinae.
OC   Bacteria; Actinobacteria; Micrococcales; Micrococcaceae; Kocuria.
OX   NCBI_TaxID=37923 {ECO:0000313|EMBL:OAX52394.1, ECO:0000313|Proteomes:UP000053171};
RN   [1] {ECO:0000313|EMBL:OAX52394.1, ECO:0000313|Proteomes:UP000053171}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RuSp02-3 {ECO:0000313|Proteomes:UP000053171};
RA   Evans L.H., Alamgir A., Owens N., Weber N.D., Virtaneva K.,
RA   Barbian K., Babar A., Rosenke K.;
RL   Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:OAX52394.1, ECO:0000313|Proteomes:UP000053171}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RuSp02-3 {ECO:0000313|Proteomes:UP000053171};
RA   Waterworth S.C., Walmsley T.A., Matongo T., Davies-Coleman M.T.,
RA   Dorrington R.A.;
RT   "Identification of putative biosynthetic pathways for the production
RT   of bioactive secondary metabolites by the marine actinomycete Kocuria
RT   kristinae RUTW2-3.";
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00735475}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00911680}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:OAX52394.1}.
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DR   EMBL; LJBJ02000004; OAX52394.1; -; Genomic_DNA.
DR   RefSeq; WP_064725058.1; NZ_LJBJ02000004.1.
DR   EnsemblBacteria; OAX52394; OAX52394; AN277_0203285.
DR   Proteomes; UP000053171; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747950};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000053171};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00911664};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00747996};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00911684};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747895};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053171}.
FT   DOMAIN      268    396       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      480    549       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     276    283       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
FT   COILED      542    569       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   577 AA;  64051 MW;  AC005B880CC46FC3 CRC64;
     MSVQGNEQIQ TRWEACIADL QNNPDLTRRV KGSLDKAQPQ GLFGTTLIIA VPNEYTRDVF
     QRELNVAFKE ALNRAFPEDM GITEAFVIDP ELETPVPGRA QATASPQQLR SPRADAAPTR
     TSGESGHSTA EGGLPTDHPR ADQARHASSE QGPGLPPISE LEAERGHVGT VPSPLHVPGA
     GQEPASLTGS RPTSAPAGSP ESEAPRPEVV TPGQDIPQMA SNTAPNDAEW ESSARLNSKY
     VFDTFVIGQS NRFAHAAALA VSEMPAKSYN PLFIYGDSGL GKTHLLHAIG HYTKRMFPHM
     RVRYVNSEEF TNDFINSIRD DEGSSFKQIY RNVDLLLIDD IQFLAGKEHT QEEFFHTFNA
     LHNHQKQVVI TSDLPPKQLT GFAERMRSRF EWGLITDVQP PELETRIAIL RKKSQSENLD
     APDEVMEYIA SNITTNIREL EGALIRVTAY ASLNKQAVDL PLAELVLKDL ITDEGVSEIT
     ASTILGQTAA YFEVSLEELR SKSRNRTLVT ARQIAMYLLR ELTDMSLPKI GQELGGRDHT
     TVMHAERKIR KLMAERRNIF NQVTELTNRI KQQHREG
//
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