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Database: UniProt
Entry: A0A1B0GUN7_HUMAN
LinkDB: A0A1B0GUN7_HUMAN
Original site: A0A1B0GUN7_HUMAN 
ID   A0A1B0GUN7_HUMAN        Unreviewed;       331 AA.
AC   A0A1B0GUN7;
DT   05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 1.
DT   10-MAY-2017, entry version 7.
DE   SubName: Full=Sodium channel protein type 1 subunit alpha {ECO:0000313|Ensembl:ENSP00000490184};
DE   Flags: Fragment;
GN   Name=SCN1A {ECO:0000313|Ensembl:ENSP00000490184};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000490184, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000490184, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA   Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA   Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA   Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA   Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA   Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA   Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA   Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA   Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA   Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA   Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA   Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA   Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA   Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA   Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA   Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA   Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA   Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA   McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA   Waterston R.H., Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2
RT   and 4.";
RL   Nature 434:724-731(2005).
RN   [2] {ECO:0000313|Ensembl:ENSP00000490184}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2016) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSP00000490184}.
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DR   EMBL; AC010127; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC107082; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENST00000637038; ENSP00000490184; ENSG00000144285.
DR   HGNC; HGNC:10585; SCN1A.
DR   OpenTargets; ENSG00000144285; -.
DR   GeneTree; ENSGT00830000128242; -.
DR   Proteomes; UP000005640; Chromosome 2.
DR   ExpressionAtlas; A0A1B0GUN7; baseline and differential.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:InterPro.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF06512; Na_trans_assoc; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:A0A1B0GUN7};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    152    170       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    191    210       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    222    242       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       26    146       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN      150    270       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   NON_TER       1      1       {ECO:0000313|Ensembl:ENSP00000490184}.
SQ   SEQUENCE   331 AA;  37530 MW;  B42DC8F402D38FEA CRC64;
     XIGKDLDYLK DVNGTTSGIG TGSSVEKYII DESDYMSFIN NPSLTVTVPI AVGESDFENL
     NTEDFSSESD LEESKEKLNE SSSSSEGSTV DIGAPVEEQP VVEPEETLEP EACFTEGCVQ
     RFKCCQINVE EGRGKQWWNL RRTCFRIVEH NWFETFIVFM ILLSSGALAF EDIYIDQRKT
     IKTMLEYADK VFTYIFILEM LLKWVAYGYQ TYFTNAWCWL DFLIVDVSLV SLTANALGYS
     ELGAIKSLRT LRALRPLRAL SRFEGMRDNL APTWMGWSAG SSPEPFIMGG CECPFRSNSI
     HHECASGLSY ILANFQHHGR KFVCWQILPL Y
//
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