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Database: UniProt
Entry: A0A1B0GVQ9_HUMAN
LinkDB: A0A1B0GVQ9_HUMAN
Original site: A0A1B0GVQ9_HUMAN 
ID   A0A1B0GVQ9_HUMAN        Unreviewed;      2266 AA.
AC   A0A1B0GVQ9;
DT   05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 1.
DT   27-SEP-2017, entry version 11.
DE   RecName: Full=Voltage-dependent P/Q-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN   Name=CACNA1A {ECO:0000313|Ensembl:ENSP00000490617};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000490617, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000490617, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
RA   Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
RA   Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
RA   Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
RA   Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
RA   Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
RA   Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
RA   Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
RA   Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
RA   Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
RA   Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
RA   Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
RA   Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
RA   Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
RA   Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000490617}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2016) to UniProtKB.
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. The isoform alpha-1A
CC       gives rise to P and/or Q-type calcium currents. P/Q-type calcium
CC       channels belong to the 'high-voltage activated' (HVA) group and
CC       are blocked by the funnel toxin (Ftx) and by the omega-agatoxin-
CC       IVA (omega-Aga-IVA). They are however insensitive to
CC       dihydropyridines (DHP), and omega-conotoxin-GVIA (omega-CTx-GVIA).
CC       {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSP00000490617}.
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DR   EMBL; AC005305; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC005513; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC011446; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC022436; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC026805; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC093062; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC098781; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC124224; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF456505; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_000059.3; NM_000068.3.
DR   UniGene; Hs.501632; -.
DR   Ensembl; ENST00000637432; ENSP00000490617; ENSG00000141837.
DR   GeneID; 773; -.
DR   CTD; 773; -.
DR   HGNC; HGNC:1388; CACNA1A.
DR   OpenTargets; ENSG00000141837; -.
DR   GeneTree; ENSGT00830000128247; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   ExpressionAtlas; A0A1B0GVQ9; baseline and differential.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR   InterPro; IPR005448; CACNA1A.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   PANTHER; PTHR10037:SF249; PTHR10037:SF249; 1.
DR   Pfam; PF08763; Ca_chan_IQ; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01632; PQVDCCALPHA1.
DR   SMART; SM01062; Ca_chan_IQ; 1.
PE   1: Evidence at protein level;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:A0A1B0GVQ9};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM    102    119       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    139    159       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    222    245       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    337    359       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    488    507       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    519    539       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    614    636       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    690    714       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1246   1265       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1285   1306       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1318   1335       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1380   1402       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1492   1517       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1573   1591       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1603   1626       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1696   1714       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1792   1816       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1953   1987       Ca_chan_IQ. {ECO:0000259|SMART:SM01062}.
FT   COILED      714    749       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2266 AA;  257443 MW;  70EDC422B08A1775 CRC64;
     MARFGDEMPA RYGGGGSGAA AGVVVGSGGG RGAGGSRQGG QPGAQRMYKQ SMAQRARTMA
     LYNPIPVRQN CLTVNRSLFL FSEDNVVRKY AKKITEWPPF EYMILATIIA NCIVLALEQH
     LPDDDKTPMS ERLDDTEPYF IGIFCFEAGI KIIALGFAFH KGSYLRNGWN VMDFVVVLTG
     ILATVGTEFD LRTLRAVRVL RPLKLVSGIP SLQVVLKSIM KAMIPLLQIG LLLFFAILIF
     AIIGLEFYMG KFHTTCFEEG TDDIQGESPA PCGTEEPART CPNGTKCQPY WEGPNNGITQ
     FDNILFAVLT VFQCITMEGW TDLLYNSNDA SGNTWNWLYF IPLIIIGSFF MLNLVLGVLS
     GEFAKERERV ENRRAFLKLR RQQQIERELN GYMEWISKAE EVILAEDETD GEQRHPFDGA
     LRRTTIKKSK TDLLNPEEAE DQLADIASVG SPFARASIKS AKLENSTFFH KKERRMRFYI
     RRMVKTQAFY WTVLSLVALN TLCVAIVHYN QPEWLSDFLY YAEFIFLGLF MSEMFIKMYG
     LGTRPYFHSS FNCFDCGVII GSIFEVIWAV IKPGTSFGIS VLRALRLLRI FKVTKYWASL
     RNLVVSLLNS MKSIISLLFL LFLFIVVFAL LGMQLFGGQF NFDEGTPPTN FDTFPAAIMT
     VFQILTGEDW NEVMYDGIKS QGGVQGGMVF SIYFIVLTLF GNYTLLNVFL AIAVDNLANA
     QELTKVEADE QEEEEAANQK LALQKAKEVA EVSPLSAANM SIAVKEQQKN QKPAKSVWEQ
     RTSEMRKQNL LASREALYNE MDPDERWKAA YTRHLRPDMK THLDRPLVVD PQENRNNNTN
     KSRAAEPTVD QRLGQQRAED FLRKQARYHD RARDPSGSAG LDARRPWAGS QEAELSREGP
     YGRESDHHAR EGSLEQPGFW EGEAERGKAG DPHRRHVHRQ GGSRESRSGS PRTGADGEHR
     RHRAHRRPGE EGPEDKAERR ARHREGSRPA RGGEGEGEGP DGGERRRRHR HGAPATYEGD
     ARREDKERRH RRRKENQGSG VPVSGPNLST TRPIQQDLGR QDPPLAEDID NMKNNKLATA
     ESAAPHGSLG HAGLPQSPAK MGNSTDPGPM LAIPAMATNP QNAASRRTPN NPGNPSNPGP
     PKTPENSLIV TNPSGTQTNS AKTARKPDHT TVDIPPACPP PLNHTVVQVN KNANPDPLPK
     KEEEKKEEEE DDRGEDGPKP MPPYSSMFIL STTNPLRRLC HYILNLRYFE MCILMVIAMS
     SIALAAEDPV QPNAPRNNVL RYFDYVFTGV FTFEMVIKMI DLGLVLHQGA YFRDLWNILD
     FIVVSGALVA FAFTGNSKGK DINTIKSLRV LRVLRPLKTI KRLPKLKAVF DCVVNSLKNV
     FNILIVYMLF MFIFAVVAVQ LFKGKFFHCT DESKEFEKDC RGKYLLYEKN EVKARDREWK
     KYEFHYDNVL WALLTLFTVS TGEGWPQVLK HSVDATFENQ GPSPGYRMEM SIFYVVYFVV
     FPFFFVNIFV ALIIITFQEQ GDKMMEEYSL EKNERACIDF AISAKPLTRH MPQNKQSFQY
     RMWQFVVSPP FEYTIMAMIA LNTIVLMMKF YGASVAYENA LRVFNIVFTS LFSLECVLKV
     MAFGILNYFR DAWNIFDFVT VLGSITDILV TEFGNPNNFI NLSFLRLFRA ARLIKLLRQG
     YTIRILLWTF VQSFKALPYV CLLIAMLFFI YAIIGMQVFG NIGIDVEDED SDEDEFQITE
     HNNFRTFFQA LMLLFRSATG EAWHNIMLSC LSGKPCDKNS GILTRECGNE FAYFYFVSFI
     FLCSFLMLNL FVAVIMDNFE YLTRDSSILG PHHLDEYVRV WAEYDPAAWG RMPYLDMYQM
     LRHMSPPLGL GKKCPARVAY KRLLRMDLPV ADDNTVHFNS TLMALIRTAL DIKIAKGGAD
     KQQMDAELRK EMMAIWPNLS QKTLDLLVTP HKSTDLTVGK IYAAMMIMEY YRQSKAKKLQ
     AMREEQDRTP LMFQRMEPPS PTQEGGPGQN ALPSTQLDPG GALMAHESGL KESPSWVTQR
     AQEMFQKTGT WSPEQGPPTD MPNSQPNSQS VEMREMGRDG YSDSEHYLPM EGQGRAASMP
     RLPAENQRRR GRPRGNNLST ISDTSPMKRS ASVLGPKARR LDDYSLERVP PEENQRHHQR
     RRDRSHRASE RSLGRYTDVD TGLGTDLSMT TQSGDLPSKE RDQERGRPKD RKHRQHHHHH
     HHHHHPPPPD KDRYAQERPD HGRARARDQR WSRSPSEGRE HMAHRQ
//
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