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Database: UniProt
Entry: A0A1B0GVX1_HUMAN
LinkDB: A0A1B0GVX1_HUMAN
Original site: A0A1B0GVX1_HUMAN 
ID   A0A1B0GVX1_HUMAN        Unreviewed;       459 AA.
AC   A0A1B0GVX1;
DT   05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 1.
DT   25-OCT-2017, entry version 10.
DE   SubName: Full=Voltage-dependent P/Q-type calcium channel subunit alpha-1A {ECO:0000313|Ensembl:ENSP00000490686};
DE   Flags: Fragment;
GN   Name=CACNA1A {ECO:0000313|Ensembl:ENSP00000490686};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000490686, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000490686, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
RA   Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
RA   Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
RA   Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
RA   Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
RA   Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
RA   Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
RA   Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
RA   Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
RA   Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
RA   Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
RA   Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
RA   Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
RA   Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
RA   Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000490686}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2016) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSP00000490686}.
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DR   EMBL; AC005305; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC005513; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC011446; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC022436; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC026805; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC093062; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC098781; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC124224; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF456505; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENST00000637819; ENSP00000490686; ENSG00000141837.
DR   HGNC; HGNC:1388; CACNA1A.
DR   OpenTargets; ENSG00000141837; -.
DR   GeneTree; ENSGT00830000128247; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   ExpressionAtlas; A0A1B0GVX1; baseline and differential.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   Pfam; PF08763; Ca_chan_IQ; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   PRINTS; PR00167; CACHANNEL.
DR   SMART; SM01062; Ca_chan_IQ; 1.
PE   1: Evidence at protein level;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:A0A1B0GVX1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM     35     53       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     65     88       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    158    176       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    254    278       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      415    449       Ca_chan_IQ. {ECO:0000259|SMART:SM01062}.
FT   NON_TER       1      1       {ECO:0000313|Ensembl:ENSP00000490686}.
FT   NON_TER     459    459       {ECO:0000313|Ensembl:ENSP00000490686}.
SQ   SEQUENCE   459 AA;  53135 MW;  745D3D6A74EA58AE CRC64;
     DFAISAKPLT RHMPQNKQSF QYRMWQFVVS PPFEYTIMAM IALNTIVLMM KFYGASVAYE
     NALRVFNIVF TSLFSLECVL KVMAFGILNY FRDAWNIFDF VTVLGSITDI LVTEFGNPNN
     FINLSFLRLF RAARLIKLLR QGYTIRILLW TFVQSFKALP YVCLLIAMLF FIYAIIGMQV
     FGNIGIDVED EDSDEDEFQI TEHNNFRTFF QALMLLFRSA TGEAWHNIML SCLSGKPCDK
     NSGILTRECG NEFAYFYFVS FIFLCSFLML NLFVAVIMDN FEYLTRDSSI LGPHHLDEYV
     RVWAEYDPAA CGRIHYKDMY SLLRVISPPL GLGKKCPHRV ACKRLLRMDL PVADDNTVHF
     NSTLMALIRT ALDIKIAKGG ADKQQMDAEL RKEMMAIWPN LSQKTLDLLV TPHKSTDLTV
     GKIYAAMMIM EYYRQSKAKK LQAMREEQDR TPLMFQRME
//
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