ID A0A1B6QKS0_SORBI Unreviewed; 825 AA.
AC A0A1B6QKS0;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=acylaminoacyl-peptidase {ECO:0000256|ARBA:ARBA00012917};
DE EC=3.4.19.1 {ECO:0000256|ARBA:ARBA00012917};
GN ORFNames=SORBI_3001G248300 {ECO:0000313|EMBL:KXG38530.1};
OS Sorghum bicolor (Sorghum) (Sorghum vulgare).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; PACMAD clade;
OC Panicoideae; Andropogonodae; Andropogoneae; Sorghinae; Sorghum.
OX NCBI_TaxID=4558 {ECO:0000313|EMBL:KXG38530.1, ECO:0000313|Proteomes:UP000000768};
RN [1] {ECO:0000313|EMBL:KXG38530.1, ECO:0000313|Proteomes:UP000000768}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. BTx623 {ECO:0000313|Proteomes:UP000000768};
RX PubMed=19189423; DOI=10.1038/nature07723;
RA Paterson A.H., Bowers J.E., Bruggmann R., Dubchak I., Grimwood J.,
RA Gundlach H., Haberer G., Hellsten U., Mitros T., Poliakov A., Schmutz J.,
RA Spannagl M., Tang H., Wang X., Wicker T., Bharti A.K., Chapman J.,
RA Feltus F.A., Gowik U., Grigoriev I.V., Lyons E., Maher C.A., Martis M.,
RA Narechania A., Otillar R.P., Penning B.W., Salamov A.A., Wang Y., Zhang L.,
RA Carpita N.C., Freeling M., Gingle A.R., Hash C.T., Keller B., Klein P.,
RA Kresovich S., McCann M.C., Ming R., Peterson D.G., Mehboob-ur-Rahman,
RA Ware D., Westhoff P., Mayer K.F., Messing J., Rokhsar D.S.;
RT "The Sorghum bicolor genome and the diversification of grasses.";
RL Nature 457:551-556(2009).
RN [2] {ECO:0000313|Proteomes:UP000000768}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. BTx623 {ECO:0000313|Proteomes:UP000000768};
RX PubMed=29161754; DOI=10.1111/tpj.13781;
RA McCormick R.F., Truong S.K., Sreedasyam A., Jenkins J., Shu S., Sims D.,
RA Kennedy M., Amirebrahimi M., Weers B.D., McKinley B., Mattison A.,
RA Morishige D.T., Grimwood J., Schmutz J., Mullet J.E.;
RT "The Sorghum bicolor reference genome: improved assembly, gene annotations,
RT a transcriptome atlas, and signatures of genome organization.";
RL Plant J. 93:338-354(2018).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Cleavage of an N-acetyl or N-formyl amino acid from the N-
CC terminus of a polypeptide.; EC=3.4.19.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000721};
CC -!- SUBUNIT: Homotetramer. {ECO:0000256|ARBA:ARBA00011881}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; CM000760; KXG38530.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1B6QKS0; -.
DR STRING; 4558.A0A1B6QKS0; -.
DR EnsemblPlants; KXG38530; KXG38530; SORBI_3001G248300.
DR Gramene; KXG38530; KXG38530; SORBI_3001G248300.
DR eggNOG; KOG2100; Eukaryota.
DR InParanoid; A0A1B6QKS0; -.
DR OrthoDB; 2877590at2759; -.
DR Proteomes; UP000000768; Chromosome 1.
DR ExpressionAtlas; A0A1B6QKS0; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IBA:GO_Central.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR InterPro; IPR045550; AARE_N.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR011659; PD40.
DR InterPro; IPR002471; Pept_S9_AS.
DR InterPro; IPR001375; Peptidase_S9.
DR PANTHER; PTHR42776:SF30; ACYLAMINO-ACID-RELEASING ENZYME 1; 1.
DR PANTHER; PTHR42776; SERINE PEPTIDASE S9 FAMILY MEMBER; 1.
DR Pfam; PF19283; APEH_N; 1.
DR Pfam; PF07676; PD40; 1.
DR Pfam; PF00326; Peptidase_S9; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF82171; DPP6 N-terminal domain-like; 1.
DR PROSITE; PS00708; PRO_ENDOPEP_SER; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000000768}.
FT DOMAIN 76..348
FT /note="Acylamino-acid-releasing enzyme N-terminal"
FT /evidence="ECO:0000259|Pfam:PF19283"
FT DOMAIN 607..824
FT /note="Peptidase S9 prolyl oligopeptidase catalytic"
FT /evidence="ECO:0000259|Pfam:PF00326"
SQ SEQUENCE 825 AA; 90371 MW; 5F582C64B159E7FA CRC64;
MVVLVKVLVT CAKFCCPAAS LLLSASTSRA RALPGGPLLR RRTSKVSLRS IAMATTQASD
AAADKGLPLA VDATMADEYA SQSKLLQEFV KIPTIGKAWI FNSKDDDMSK AVVSIGQTDL
LANKRRQFLL NSHISKSPKS VDFKWSPFPT EISGASAVIP SPSGEKLLLV RNSEDDSPTK
LEIWGPCQLE NEIHIAKSVH GSLYTDEWFG GISWNQEETF IAYVAEEPPQ PKPVFNDYGF
KKEGSSEKDC KSWKGQGDWE ETWGETYSKK RIPALFVVNI SSGEVRPVKQ IPRSLSVGQV
IWAPSSSYSL VFVAWSSDNG FQETPRKLGI KYCYNRPCAL YAAPDPFREE AEKSSTEGNK
SETTTMIKLT GDLISAFFPR FSPDGKYLVF ISAKSAVDSG AHNATNSMHR IEWPADGNLD
GSLGIADVVA VVMCPKDNCF PGLYCFGLLR DPWLTDGQTM IISSVWGSRE VILSVNVVSC
EVSRVSPQDS DYSWNVLAVD KNNILAVSSS LITLPQMYYA IKVPQTESNW EWQEVSTPFP
KPSDKISSIL AEHKFSILKI PISNPSDKLA NGAKLPFEAI FVSHKDSASN PTIVVLHGGP
HSVYPSSYSK SLAFLFSQGY NLLVVNYRGS LGFGEEALQS LPGNIGSQDV NDVLTALDLV
IKRGLIDPSR VAVVGGSHGG FLTTHLIGQA PDTFVAAAAR NPVCNLSLMV GTSDIPDWCF
VEIYGKEGKK YFSESPSVDD ICQFHQKSPI SHISEVKTPT LFLLGAQDLR VPVSNGLQYA
RALKERGIES KTIIFPEDIH GIDKPQSDFE SFLNIGVWFK KHMSK
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