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Database: UniProt
Entry: A0A1B8Y2Z3_XENTR
LinkDB: A0A1B8Y2Z3_XENTR
Original site: A0A1B8Y2Z3_XENTR 
ID   A0A1B8Y2Z3_XENTR        Unreviewed;       513 AA.
AC   A0A1B8Y2Z3;
DT   02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT   02-NOV-2016, sequence version 1.
DT   28-MAR-2018, entry version 10.
DE   RecName: Full=Triacylglycerol lipase {ECO:0000256|RuleBase:RU362046};
DE            EC=3.1.1.3 {ECO:0000256|RuleBase:RU362046};
DE   AltName: Full=Pancreatic lipase {ECO:0000256|RuleBase:RU362046};
GN   ORFNames=XENTR_v90027329mg {ECO:0000313|EMBL:OCA17274.1};
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus;
OC   Silurana.
OX   NCBI_TaxID=8364 {ECO:0000313|EMBL:OCA17274.1, ECO:0000313|Proteomes:UP000008143};
RN   [1] {ECO:0000313|EMBL:OCA17274.1, ECO:0000313|Proteomes:UP000008143}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Nigerian {ECO:0000313|EMBL:OCA17274.1,
RC   ECO:0000313|Proteomes:UP000008143};
RX   PubMed=20431018; DOI=10.1126/science.1183670;
RA   Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA   Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L.,
RA   Blitz I.L., Blumberg B., Dichmann D.S., Dubchak I., Amaya E.,
RA   Detter J.C., Fletcher R., Gerhard D.S., Goodstein D., Graves T.,
RA   Grigoriev I.V., Grimwood J., Kawashima T., Lindquist E., Lucas S.M.,
RA   Mead P.E., Mitros T., Ogino H., Ohta Y., Poliakov A.V., Pollet N.,
RA   Robert J., Salamov A., Sater A.K., Schmutz J., Terry A., Vize P.D.,
RA   Warren W.C., Wells D., Wills A., Wilson R.K., Zimmerman L.B.,
RA   Zorn A.M., Grainger R., Grammer T., Khokha M.K., Richardson P.M.,
RA   Rokhsar D.S.;
RT   "The genome of the Western clawed frog Xenopus tropicalis.";
RL   Science 328:633-636(2010).
CC   -!- CATALYTIC ACTIVITY: Triacylglycerol + H(2)O = diacylglycerol + a
CC       carboxylate. {ECO:0000256|RuleBase:RU362046}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU362046,
CC       ECO:0000256|SAAS:SAAS00553472}.
CC   -!- SIMILARITY: Belongs to the AB hydrolase superfamily. Lipase
CC       family. {ECO:0000256|RuleBase:RU004262,
CC       ECO:0000256|SAAS:SAAS00591292}.
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DR   EMBL; KV460512; OCA17274.1; -; Genomic_DNA.
DR   RefSeq; XP_012821763.1; XM_012966309.1.
DR   UniGene; Str.66913; -.
DR   GeneID; 394967; -.
DR   Proteomes; UP000008143; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0004806; F:triglyceride lipase activity; IEA:UniProtKB-EC.
DR   GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR   CDD; cd00707; Pancreat_lipase_like; 1.
DR   Gene3D; 3.40.50.1820; -; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR013818; Lipase/vitellogenin.
DR   InterPro; IPR016272; Lipase_LIPH.
DR   InterPro; IPR033906; Lipase_N.
DR   InterPro; IPR002331; Lipase_panc.
DR   InterPro; IPR001024; PLAT/LH2_dom.
DR   InterPro; IPR036392; PLAT/LH2_dom_sf.
DR   InterPro; IPR000734; TAG_lipase.
DR   PANTHER; PTHR11610; PTHR11610; 1.
DR   Pfam; PF00151; Lipase; 1.
DR   Pfam; PF01477; PLAT; 1.
DR   PIRSF; PIRSF000865; Lipoprotein_lipase_LIPH; 1.
DR   PRINTS; PR00823; PANCLIPASE.
DR   PRINTS; PR00821; TAGLIPASE.
DR   SMART; SM00308; LH2; 1.
DR   SUPFAM; SSF49723; SSF49723; 1.
DR   SUPFAM; SSF53474; SSF53474; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000008143};
KW   Disulfide bond {ECO:0000256|RuleBase:RU362046,
KW   ECO:0000256|SAAS:SAAS00709807};
KW   Lipid degradation {ECO:0000256|RuleBase:RU362046};
KW   Lipid metabolism {ECO:0000256|RuleBase:RU362046};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008143};
KW   Secreted {ECO:0000256|RuleBase:RU362046,
KW   ECO:0000256|SAAS:SAAS00439306}.
FT   DOMAIN      396    508       PLAT. {ECO:0000259|SMART:SM00308}.
FT   ACT_SITE    212    212       Nucleophile. {ECO:0000256|PIRSR:
FT                                PIRSR000865-1}.
FT   ACT_SITE    235    235       Charge relay system. {ECO:0000256|PIRSR:
FT                                PIRSR000865-1}.
FT   ACT_SITE    322    322       Charge relay system. {ECO:0000256|PIRSR:
FT                                PIRSR000865-1}.
SQ   SEQUENCE   513 AA;  56371 MW;  CB86657189BCE8BB CRC64;
     MEAGPAPGRG GLCAIWLLPP GSVYQFPAEP DPEQLLWNHH KMLGLWGLFF FLLGCVQGEP
     VCYDKIGCFS DEKPWSGTLE RPIARLPSSP EHINTRLLLF TRENAENFQE LRPLNPSAVS
     LTNFKTSRKS RFIIHGFIDE GEENWLVNMC KAMLKVEDVN CFCTDWSGGS RTIYTQAANN
     IRVVGAELAY FIGYLSSKMK YPLSNVHIIG HSLGSHTAGE VGKRMPGIGR ITGLDPAGPY
     FQNTPIEVRL DPTDAVFVDA IHTDTDPLIP KMGYGMSQSV AHMDFFPNGG ENMPGCSKPI
     LAKLLDIDGL WEGSKDIFAC NHLRSYKYYT ESISSPDGFV GYPSTSYEAF TKGTGFPCPT
     TGCPLMGHYA DAFSSHGTSD YSYFLNTGSE KPYSRWRYRV SVKTTGSVNF LGSVQVLLNG
     IKGSTKGEEI ASGFIKPGST YSAFIDVEAD VGPLITVSFT WKKSLINLIP FTVGAEMITV
     QYGKDGQTYE FCGKDAVRAN NLQSLTSCYS ATK
//
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