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Database: UniProt
Entry: A0A1C7CYY9_HUMAN
LinkDB: A0A1C7CYY9_HUMAN
Original site: A0A1C7CYY9_HUMAN 
ID   A0A1C7CYY9_HUMAN        Unreviewed;      2508 AA.
AC   A0A1C7CYY9;
DT   02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT   02-NOV-2016, sequence version 1.
DT   27-SEP-2017, entry version 10.
DE   RecName: Full=Voltage-dependent P/Q-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN   Name=CACNA1A {ECO:0000313|Ensembl:ENSP00000460092};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000460092, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000460092, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
RA   Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
RA   Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
RA   Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
RA   Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
RA   Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
RA   Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
RA   Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
RA   Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
RA   Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
RA   Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
RA   Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
RA   Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
RA   Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
RA   Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000460092}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2016) to UniProtKB.
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. The isoform alpha-1A
CC       gives rise to P and/or Q-type calcium currents. P/Q-type calcium
CC       channels belong to the 'high-voltage activated' (HVA) group and
CC       are blocked by the funnel toxin (Ftx) and by the omega-agatoxin-
CC       IVA (omega-Aga-IVA). They are however insensitive to
CC       dihydropyridines (DHP), and omega-conotoxin-GVIA (omega-CTx-GVIA).
CC       {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSP00000460092}.
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DR   EMBL; AC005305; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC005513; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC011446; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC022436; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC026805; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC093062; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC098781; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC124224; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF456505; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENST00000573710; ENSP00000460092; ENSG00000141837.
DR   HGNC; HGNC:1388; CACNA1A.
DR   OpenTargets; ENSG00000141837; -.
DR   GeneTree; ENSGT00830000128247; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   ExpressionAtlas; A0A1C7CYY9; baseline and differential.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR   InterPro; IPR005448; CACNA1A.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   PANTHER; PTHR10037:SF249; PTHR10037:SF249; 1.
DR   Pfam; PF08763; Ca_chan_IQ; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01632; PQVDCCALPHA1.
DR   SMART; SM01062; Ca_chan_IQ; 1.
PE   1: Evidence at protein level;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:A0A1C7CYY9};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM    102    119       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    139    159       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    222    245       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    337    359       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    489    508       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    520    540       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    615    637       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    691    715       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1244   1263       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1283   1304       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1316   1333       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1378   1400       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1490   1515       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1571   1589       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1601   1624       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1692   1710       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1788   1812       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1949   1983       Ca_chan_IQ. {ECO:0000259|SMART:SM01062}.
FT   COILED      711    747       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2508 AA;  282565 MW;  8CE4D1B372705485 CRC64;
     MARFGDEMPA RYGGGGSGAA AGVVVGSGGG RGAGGSRQGG QPGAQRMYKQ SMAQRARTMA
     LYNPIPVRQN CLTVNRSLFL FSEDNVVRKY AKKITEWPPF EYMILATIIA NCIVLALEQH
     LPDDDKTPMS ERLDDTEPYF IGIFCFEAGI KIIALGFAFH KGSYLRNGWN VMDFVVVLTG
     ILATVGTEFD LRTLRAVRVL RPLKLVSGIP SLQVVLKSIM KAMIPLLQIG LLLFFAILIF
     AIIGLEFYMG KFHTTCFEEG TDDIQGESPA PCGTEEPART CPNGTKCQPY WEGPNNGITQ
     FDNILFAVLT VFQCITMEGW TDLLYNSNDA SGNTWNWLYF IPLIIIGSFF MLNLVLGVLS
     GEFAKERERV ENRRAFLKLR RQQQIERELN GYMEWISKAE EVILAEDETD GEQRHPFDVG
     ALRRTTIKKS KTDLLNPEEA EDQLADIASV GSPFARASIK SAKLENSTFF HKKERRMRFY
     IRRMVKTQAF YWTVLSLVAL NTLCVAIVHY NQPEWLSDFL YYAEFIFLGL FMSEMFIKMY
     GLGTRPYFHS SFNCFDCGVI IGSIFEVIWA VIKPGTSFGI SVLRALRLLR IFKVTKYWAS
     LRNLVVSLLN SMKSIISLLF LLFLFIVVFA LLGMQLFGGQ FNFDEGTPPT NFDTFPAAIM
     TVFQILTGED WNEVMYDGIK SQGGVQGGMV FSIYFIVLTL FGNYTLLNVF LAIAVDNLAN
     AQELTKDEQE EEEAANQKLA LQKAKEVAEV SPLSAANMSI AVKEQQKNQK PAKSVWEQRT
     SEMRKQNLLA SREALYNEMD PDERWKAAYT RHLRPDMKTH LDRPLVVDPQ ENRNNNTNKS
     RAAEPTVDQR LGQQRAEDFL RKQARYHDRA RDPSGSAGLD ARRPWAGSQE AELSREGPYG
     RESDHHAREG SLEQPGFWEG EAERGKAGDP HRRHVHRQGG SRESRSGSPR TGADGEHRRH
     RAHRRPGEEG PEDKAERRAR HREGSRPARG GEGEGEGPDG GERRRRHRHG APATYEGDAR
     REDKERRHRR RKENQGSGVP VSGPNLSTTR PIQQDLGRQD PPLAEDIDNM KNNKLATAES
     AAPHGSLGHA GLPQSPAKMG NSTDPGPMLA IPAMATNPQN AASRRTPNNP GNPSNPGPPK
     TPENSLIVTN PSGTQTNSAK TARKPDHTTV DIPPACPPPL NHTVVQVNKN ANPDPLPKKE
     EEKKEEEEDD RGEDGPKPMP PYSSMFILST TNPLRRLCHY ILNLRYFEMC ILMVIAMSSI
     ALAAEDPVQP NAPRNNVLRY FDYVFTGVFT FEMVIKMIDL GLVLHQGAYF RDLWNILDFI
     VVSGALVAFA FTGNSKGKDI NTIKSLRVLR VLRPLKTIKR LPKLKAVFDC VVNSLKNVFN
     ILIVYMLFMF IFAVVAVQLF KGKFFHCTDE SKEFEKDCRG KYLLYEKNEV KARDREWKKY
     EFHYDNVLWA LLTLFTVSTG EGWPQVLKHS VDATFENQGP SPGYRMEMSI FYVVYFVVFP
     FFFVNIFVAL IIITFQEQGD KMMEEYSLEK NERACIDFAI SAKPLTRHMP QNKQSFQYRM
     WQFVVSPPFE YTIMAMIALN TIVLMMKFYG ASVAYENALR VFNIVFTSLF SLECVLKVMA
     FGILNYFRDA WNIFDFVTVL GSITDILVTE FGNNFINLSF LRLFRAARLI KLLRQGYTIR
     ILLWTFVQSF KALPYVCLLI AMLFFIYAII GMQVFGNIGI DVEDEDSDED EFQITEHNNF
     RTFFQALMLL FRSATGEAWH NIMLSCLSGK PCDKNSGILT RECGNEFAYF YFVSFIFLCS
     FLMLNLFVAV IMDNFEYLTR DSSILGPHHL DEYVRVWAEY DPAACGRIHY KDMYSLLRVI
     SPPLGLGKKC PHRVACKRLL RMDLPVADDN TVHFNSTLMA LIRTALDIKI AKGGADKQQM
     DAELRKEMMA IWPNLSQKTL DLLVTPHKST DLTVGKIYAA MMIMEYYRQS KAKKLQAMRE
     EQDRTPLMFQ RMEPPSPTQE GGPGQNALPS TQLDPGGALM AHESGLKESP SWVTQRAQEM
     FQKTGTWSPE QGPPTDMPNS QPNSQSVEMR EMGRDGYSDS EHYLPMEGQG RAASMPRLPA
     ENQRRRGRPR GNNLSTISDT SPMKRSASVL GPKARRLDDY SLERVPPEEN QRHHQRRRDR
     SHRASERSLG RYTDVDTGLG TDLSMTTQSG DLPSKERDQE RGRPKDRKHR QHHHHHHHHH
     HPPPPDKDRY AQERPDHGRA RARDQRWSRS PSEGREHMAH RQGSSSVSGS PAPSTSGTST
     PRRGRRQLPQ TPSTPRPHVS YSPVIRKAGG SGPPQQQQQQ QQQQQQQAVA RPGRAATSGP
     RRYPGPTAEP LAGDRPPTGG HSSGRSPRME RRVPGPARSE SPRACRHGGA RWPASGPHVS
     EGPPGPRHHG YYRGSDYDEA DGPGSGGGEE AMAGAYDAPP PVRHASSGAT GRSPRTPRAS
     GPACASPSRH GRRLPNGYYP AHGLARPRGP GSRKGLHEPY SESDDDWC
//
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