ID A0AG35_LISW6 Unreviewed; 524 AA.
AC A0AG35;
DT 28-NOV-2006, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2006, sequence version 1.
DT 27-MAR-2024, entry version 86.
DE RecName: Full=Probable endopeptidase p60 {ECO:0000256|ARBA:ARBA00013385};
DE AltName: Full=Invasion-associated protein p60 {ECO:0000256|ARBA:ARBA00032855};
GN Name=iap {ECO:0000313|EMBL:CAK19967.1};
GN OrderedLocusNames=lwe0549 {ECO:0000313|EMBL:CAK19967.1};
OS Listeria welshimeri serovar 6b (strain ATCC 35897 / DSM 20650 / CIP 8149 /
OS NCTC 11857 / SLCC 5334 / V8).
OC Bacteria; Bacillota; Bacilli; Bacillales; Listeriaceae; Listeria.
OX NCBI_TaxID=386043 {ECO:0000313|EMBL:CAK19967.1, ECO:0000313|Proteomes:UP000000779};
RN [1] {ECO:0000313|EMBL:CAK19967.1, ECO:0000313|Proteomes:UP000000779}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35897 / DSM 20650 / CIP 8149 / NCTC 11857 / SLCC 5334 / V8
RC {ECO:0000313|Proteomes:UP000000779};
RX PubMed=16936040; DOI=10.1128/JB.00758-06;
RA Hain T., Steinweg C., Kuenne C.T., Billion A., Ghai R., Chatterjee S.S.,
RA Domann E., Kaerst U., Goesmann A., Bekel T., Bartels D., Kaiser O.,
RA Meyer F., Puehler A., Weisshaar B., Wehland J., Liang C., Dandekar T.,
RA Lampidis R., Kreft J., Goebel W., Chakraborty T.;
RT "Whole-genome sequence of Listeria welshimeri reveals common steps in
RT genome reduction with Listeria innocua as compared to Listeria
RT monocytogenes.";
RL J. Bacteriol. 188:7405-7415(2006).
CC -!- FUNCTION: This major extracellular protein may be involved in the
CC invasion of non-professional phagocytic cells by Listeria.
CC {ECO:0000256|ARBA:ARBA00003740}.
CC -!- SIMILARITY: Belongs to the peptidase C40 family.
CC {ECO:0000256|ARBA:ARBA00007074}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AM263198; CAK19967.1; -; Genomic_DNA.
DR AlphaFoldDB; A0AG35; -.
DR SMR; A0AG35; -.
DR STRING; 386043.lwe0549; -.
DR CAZy; CBM50; Carbohydrate-Binding Module Family 50.
DR KEGG; lwe:lwe0549; -.
DR eggNOG; COG0791; Bacteria.
DR eggNOG; COG1388; Bacteria.
DR eggNOG; COG3103; Bacteria.
DR HOGENOM; CLU_581142_0_0_9; -.
DR Proteomes; UP000000779; Chromosome.
DR GO; GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00118; LysM; 3.
DR Gene3D; 3.90.1720.10; endopeptidase domain like (from Nostoc punctiforme); 1.
DR Gene3D; 3.10.350.10; LysM domain; 3.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR018392; LysM_dom.
DR InterPro; IPR036779; LysM_dom_sf.
DR InterPro; IPR000064; NLP_P60_dom.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR003646; SH3-like_bac-type.
DR PANTHER; PTHR47053; MUREIN DD-ENDOPEPTIDASE MEPH-RELATED; 1.
DR PANTHER; PTHR47053:SF1; MUREIN DD-ENDOPEPTIDASE MEPH-RELATED; 1.
DR Pfam; PF01476; LysM; 3.
DR Pfam; PF00877; NLPC_P60; 1.
DR Pfam; PF08239; SH3_3; 1.
DR SMART; SM00257; LysM; 3.
DR SMART; SM00287; SH3b; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR SUPFAM; SSF54106; LysM domain; 3.
DR PROSITE; PS51782; LYSM; 3.
DR PROSITE; PS51935; NLPC_P60; 1.
DR PROSITE; PS51781; SH3B; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022807};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Thiol protease {ECO:0000256|ARBA:ARBA00022807}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..524
FT /note="Probable endopeptidase p60"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5038474418"
FT DOMAIN 28..71
FT /note="LysM"
FT /evidence="ECO:0000259|PROSITE:PS51782"
FT DOMAIN 78..142
FT /note="SH3b"
FT /evidence="ECO:0000259|PROSITE:PS51781"
FT DOMAIN 196..239
FT /note="LysM"
FT /evidence="ECO:0000259|PROSITE:PS51782"
FT DOMAIN 314..357
FT /note="LysM"
FT /evidence="ECO:0000259|PROSITE:PS51782"
FT DOMAIN 406..524
FT /note="NlpC/P60"
FT /evidence="ECO:0000259|PROSITE:PS51935"
FT REGION 150..188
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 272..313
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 360..408
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 150..180
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 272..294
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 524 AA; 54086 MW; 22EAFE5DC4A254C9 CRC64;
MNMKKATIAA TAGIAVTAFA APTIASASTV VVEAGDTLWG IAQSKGTTVD ALKKANNLTS
DKIVPGQKLQ VTEVASEKTE KSVSATWLNV RSGAGVDNSI VTSLKGGTKV TVEAAESNGW
NKISYGEGKT GYVNGKYLGD AVTSAPVAKQ EVKQETTKQT APAAETKTEV KQSTPAPTAP
KAAETKTAPV VDTNATTHTV KSGDTIWALS VKYGASVQDL MSWNNLSSSS IYVGQKIAVK
QSAAKTAAPK AEVKTEAPAV EKETSTPVVK ENTNTTVKKE VTTQTQTNTT KAPAQAAKPA
PAPAPAPTVN TNASTYTVKS GDSLSKIANT FGTSVSKIKA LNNLTSDNLQ VGTVLKVKGT
VPTTNTNNNS NTTAPTTNTS NNNTSSNTST PSKNTNTNTN QGSSNSASAS ALIAEAQKHL
GKAYSWGGNG PTTFDCSGFT SYVFAKSGIS LPRTSGAQYA STSRISESQA KPGDLVFFDY
GSGIAHVGIY VGNGQMINAQ DNGVKYDNIH GSGWGKYLVG FGRV
//
